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Aldh1b1 aldehyde dehydrogenase 1 family, member B1 [ Mus musculus (house mouse) ]

Gene ID: 72535, updated on 21-Apr-2024

Summary

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Official Symbol
Aldh1b1provided by MGI
Official Full Name
aldehyde dehydrogenase 1 family, member B1provided by MGI
Primary source
MGI:MGI:1919785
See related
Ensembl:ENSMUSG00000035561 AllianceGenome:MGI:1919785
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2700007F14Rik
Summary
Predicted to enable aldehyde dehydrogenase (NAD+) activity. Located in mitochondrion. Is expressed in several structures, including alimentary system; hemolymphoid system; and liver. Orthologous to human ALDH1B1 (aldehyde dehydrogenase 1 family member B1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in large intestine adult (RPKM 182.6), duodenum adult (RPKM 64.0) and 9 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 B1; 4 24.35 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (45799022..45804608)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (45799022..45804608)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31563 Neighboring gene STARR-seq mESC enhancer starr_10108 Neighboring gene STARR-seq mESC enhancer starr_10110 Neighboring gene predicted gene 12409 Neighboring gene insulin-like growth factor binding protein-like 1 Neighboring gene STARR-seq mESC enhancer starr_10113 Neighboring gene STRA6-like Neighboring gene STARR-seq mESC enhancer starr_10114 Neighboring gene coiled-coil domain containing 180

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The murine hepatic sequelae of long-term ethanol consumption are sex-specific and exacerbated by Aldh1b1 loss. Müller MF, et al. Exp Mol Pathol, 2018 Aug. PMID 29859945
  2. Effects of long-term ethanol consumption and Aldh1b1 depletion on intestinal tumourigenesis in mice. Müller MF, et al. J Pathol, 2017 Apr. PMID 28026023
  3. ALDH1B1 links alcohol consumption and diabetes. Singh S, et al. Biochem Biophys Res Commun, 2015 Aug 7. PMID 26086111, Free PMC Article
  4. Aldh1b1 expression defines progenitor cells in the adult pancreas and is required for Kras-induced pancreatic cancer. Mameishvili E, et al. Proc Natl Acad Sci U S A, 2019 Oct 8. PMID 31548432, Free PMC Article
  5. Protein Methyltransferase Inhibition Decreases Endocrine Specification Through the Upregulation of Aldh1b1 Expression. Giannios I, et al. Stem Cells, 2019 May. PMID 30681750, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The aldehyde dehydrogenase ALDH1B1 exerts antiviral effects through the aggregation of the adaptor MAVS.
    Title: The aldehyde dehydrogenase ALDH1B1 exerts antiviral effects through the aggregation of the adaptor MAVS.
  2. Acetaldehyde and defective mismatch repair increase colonic tumours in a Lynch syndrome model with Aldh1b1 inactivation.
    Title: Acetaldehyde and defective mismatch repair increase colonic tumours in a Lynch syndrome model with Aldh1b1 inactivation.
  3. We identified AMI-5, a protein methyltransferase inhibitor, as an Aldh1b1 inducer and showed that it can maintain Aldh1b1 expression in embryonic pancreas explants. This led to a selective reduction in endocrine specification. This effect was due to a downregulation of Ngn3, and it was mediated through Aldh1b1 since the effect was abolished in Aldh1b1 null pancreata.
    Title: Protein Methyltransferase Inhibition Decreases Endocrine Specification Through the Upregulation of Aldh1b1 Expression.
  4. Overexpression of Aldh1b1 is associated with pancreatic cancer development.
    Title: Aldh1b1 expression defines progenitor cells in the adult pancreas and is required for Kras-induced pancreatic cancer.
  5. Aldehyde dehydrogenase has a critical role for beta cell development and functionality in mice
    Title: Aldehyde dehydrogenase activity is necessary for beta cell development and functionality in mice.
  6. show for the first time the functional in vivo role of ALDH1B1 in acetaldehyde metabolism and in maintaining glucose homeostasis
    Title: ALDH1B1 links alcohol consumption and diabetes.
  7. ALDH1B1 is a potential stem/progenitor marker for multiple pancreas progenitor pools
    Title: ALDH1B1 is a potential stem/progenitor marker for multiple pancreas progenitor pools.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC101971

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables aldehyde dehydrogenase (NAD+) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
aldehyde dehydrogenase X, mitochondrial
Names
aldehyde dehydrogenase family 1 member B1
NP_082546.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028270.4 → NP_082546.1  aldehyde dehydrogenase X, mitochondrial precursor

    See identical proteins and their annotated locations for NP_082546.1

    Status: VALIDATED

    Source sequence(s)
    AK153416, AW555370, CJ158368
    Consensus CDS
    CCDS18139.1
    UniProtKB/Swiss-Prot
    Q3UAH5, Q9CZS1
    Related
    ENSMUSP00000041260.5, ENSMUST00000044384.5
    Conserved Domains (2) summary
    cd07141
    Location:33 → 513
    ALDH_F1AB_F2_RALDH1; NAD+-dependent retinal dehydrogenase 1, ALDH families 1A, 1B, and 2-like
    PLN02466
    Location:22 → 518
    PLN02466; aldehyde dehydrogenase family 2 member

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    45799022..45804608
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CZS1.1 GenPept UniProtKB/Swiss-Prot:Q9CZS1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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