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Tmem87b transmembrane protein 87B [ Mus musculus (house mouse) ]

Gene ID: 72477, updated on 11-Apr-2024

Summary

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Official Symbol
Tmem87bprovided by MGI
Official Full Name
transmembrane protein 87Bprovided by MGI
Primary source
MGI:MGI:1919727
See related
Ensembl:ENSMUSG00000014353 AllianceGenome:MGI:1919727
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2610301K12Rik; 2810431I02Rik
Summary
Predicted to be involved in retrograde transport, endosome to Golgi. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus and membrane. Is expressed in medulla oblongata; medulla oblongata basal plate mantle layer; and spinal cord. Orthologous to human TMEM87B (transmembrane protein 87B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 10.7), placenta adult (RPKM 10.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 F1; 2 62.63 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (128659991..128696181)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (128818303..128854261)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene anaphase promoting complex subunit 1 Neighboring gene STARR-positive B cell enhancer ABC_E4498 Neighboring gene predicted gene, 39931 Neighboring gene VISTA enhancer mm1476 Neighboring gene MER proto-oncogene tyrosine kinase Neighboring gene STARR-seq mESC enhancer starr_05650 Neighboring gene STARR-seq mESC enhancer starr_05651 Neighboring gene STARR-positive B cell enhancer ABC_E2046 Neighboring gene fibulin 7 Neighboring gene STARR-seq mESC enhancer starr_05654 Neighboring gene STARR-positive B cell enhancer ABC_E7861 Neighboring gene zinc finger CCCH type containing 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  2. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in retrograde transport, endosome to Golgi IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retrograde transport, endosome to Golgi ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
transmembrane protein 87B
Names
novel lung seven transmembrane receptor domain containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355628.1 → NP_001342557.1  transmembrane protein 87B isoform a precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK011959, AL808104
    UniProtKB/TrEMBL
    Z4YML9
    Related
    ENSMUSP00000119093.2, ENSMUST00000152210.2
    Conserved Domains (1) summary
    pfam06814
    Location:175 → 467
    Lung_7-TM_R; Lung seven transmembrane receptor

  2. NM_001355629.1 → NP_001342558.1  transmembrane protein 87B isoform c precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate in-frame exon and lacks another alternate in-frame exon compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AL808104
    Consensus CDS
    CCDS89553.1
    UniProtKB/TrEMBL
    A0A5F8MPT2, Z4YML9
    Related
    ENSMUSP00000159105.2, ENSMUST00000143398.3
    Conserved Domains (1) summary
    pfam06814
    Location:175 → 459
    Lung_7-TM_R; Lung seven transmembrane receptor

  3. NM_028248.2 → NP_082524.2  transmembrane protein 87B isoform b precursor

    See identical proteins and their annotated locations for NP_082524.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses two alternate splice junctions compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AI449240, AK011959, AK050955, AL808104, BY482777, CA479832, CN458042
    Consensus CDS
    CCDS38234.1
    UniProtKB/Swiss-Prot
    A2AN76, Q3T9D2, Q8BKU8, Q8K0G0, Q9D001
    UniProtKB/TrEMBL
    Z4YML9
    Related
    ENSMUSP00000105954.2, ENSMUST00000110325.8
    Conserved Domains (1) summary
    pfam06814
    Location:175 → 459
    Lung_7-TM_R; Lung seven transmembrane receptor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    128659991..128696181
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_004940742.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BKU8.1 GenPept UniProtKB/Swiss-Prot:Q8BKU8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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