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Plcd3 phospholipase C, delta 3 [ Mus musculus (house mouse) ]

Gene ID: 72469, updated on 11-Apr-2024

Summary

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Official Symbol
Plcd3provided by MGI
Official Full Name
phospholipase C, delta 3provided by MGI
Primary source
MGI:MGI:107451
See related
Ensembl:ENSMUSG00000020937 AllianceGenome:MGI:107451
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1964; 2610205J15Rik
Summary
Predicted to enable phosphatidylinositol phospholipase C activity. Acts upstream of or within angiogenesis; labyrinthine layer blood vessel development; and regulation of cell population proliferation. Predicted to be located in cytosol and membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Orthologous to human PLCD3 (phospholipase C delta 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 8.4), stomach adult (RPKM 7.5) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 E1; 11 66.71 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (102960062..102992484, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (103070296..103101710, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_30823 Neighboring gene dephospho-CoA kinase domain containing Neighboring gene microRNA 6931 Neighboring gene STARR-positive B cell enhancer ABC_E8458 Neighboring gene STARR-positive B cell enhancer ABC_E7071 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:102889625-102889808 Neighboring gene STARR-seq mESC enhancer starr_30825 Neighboring gene N-myristoyltransferase 1 Neighboring gene predicted gene, 42090 Neighboring gene STARR-seq mESC enhancer starr_30831 Neighboring gene STARR-positive B cell enhancer ABC_E204 Neighboring gene acyl-Coenzyme A binding domain containing 4 Neighboring gene STARR-positive B cell enhancer ABC_E4004 Neighboring gene STARR-positive B cell enhancer ABC_E738 Neighboring gene hexamethylene bis-acetamide inducible 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Phospholipase Cdelta3 regulates RhoA/Rho kinase signaling and neurite outgrowth. Kouchi Z, et al. J Biol Chem, 2011 Mar 11. PMID 21187285, Free PMC Article
  2. Phospholipase Cδ3 is a novel binding partner of myosin VI and functions as anchoring of myosin VI on plasma membrane. Sakurai K, et al. Adv Enzyme Regul, 2011. PMID 21035487
  3. Physiological functions of phospholipase C delta-type. Fukami K, et al. Adv Enzyme Regul, 2008. PMID 18177742
  4. Alopecia in a viable phospholipase C delta 1 and phospholipase C delta 3 double mutant. Runkel F, et al. PLoS One, 2012. PMID 22723964, Free PMC Article
  5. Simultaneous loss of phospholipase Cδ1 and phospholipase Cδ3 causes cardiomyocyte apoptosis and cardiomyopathy. Nakamura Y, et al. Cell Death Dis, 2014 May 8. PMID 24810051, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results indicate that PLCdelta1 and PLCdelta3 are required for cardiomyocyte survival and normal cardiac function.
    Title: Simultaneous loss of phospholipase Cδ1 and phospholipase Cδ3 causes cardiomyocyte apoptosis and cardiomyopathy.
  2. Plcd1 and Plcd3 have synergistic effects on the murine hair follicle in specific regions of the body surface.
    Title: Alopecia in a viable phospholipase C delta 1 and phospholipase C delta 3 double mutant.
  3. These results indicate that PLCdelta3 could participate in stability of microvilli structure via regulating and anchoring of Myo6 to plasma membrane.
    Title: Phospholipase Cδ3 is a novel binding partner of myosin VI and functions as anchoring of myosin VI on plasma membrane.
  4. PLCdelta3 negatively regulates RhoA expression, inhibits RhoA/Rho kinase signaling, and thereby promotes neurite extension.
    Title: Phospholipase Cdelta3 regulates RhoA/Rho kinase signaling and neurite outgrowth.
  5. double disruption of PLCd1 and PLCd3 results in embryonic lethality because of insufficient vasculariztion of the placenta.
    Title: Physiological functions of phospholipase C delta-type.
  6. PLCdelta1 and PLCdelta3 are essential in trophoblasts for placental development.
    Title: Phospholipase C-delta1 and -delta3 are essential in the trophoblast for placental development.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol phospholipase C activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphoric diester hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within angiogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within labyrinthine layer blood vessel development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of cell population proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3
Names
PLC-delta-3
phosphoinositide phospholipase C-delta-3
NP_001348635.1
NP_690026.2
XP_006534371.1
XP_006534372.1
XP_017170277.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001361706.1 → NP_001348635.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AL731805
    Conserved Domains (4) summary
    cd08630
    Location:272 → 567
    PI-PLCc_delta3; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-delta3
    cd13363
    Location:1 → 117
    PH_PLC_delta; Phospholipase C-delta (PLC-delta) pleckstrin homology (PH) domain
    pfam14788
    Location:137 → 186
    EF-hand_10; EF hand
    cl27705
    Location:191 → 718
    PI-PLC-Y; Phosphatidylinositol-specific phospholipase C, Y domain

  2. NM_152813.3 → NP_690026.2  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform 1

    See identical proteins and their annotated locations for NP_690026.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK011892, AK046669, AL731805, BY011789, BY589869
    Consensus CDS
    CCDS25512.1
    UniProtKB/Swiss-Prot
    A2AHR0, A2AHR1, Q3UME8, Q69Z55, Q8BL19, Q8K2J0
    Related
    ENSMUSP00000099366.2, ENSMUST00000103077.2
    Conserved Domains (7) summary
    cd00275
    Location:656 → 783
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08630
    Location:332 → 627
    PI-PLCc_delta3; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-delta3
    PLN02228
    Location:251 → 778
    PLN02228; Phosphoinositide phospholipase C
    cd13363
    Location:61 → 177
    PH_PLC_delta; Phospholipase C-delta (PLC-delta) pleckstrin homology (PH) domain
    pfam00169
    Location:66 → 163
    PH; PH domain
    pfam09279
    Location:251 → 332
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    pfam14788
    Location:197 → 246
    EF-hand_10; EF hand

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    102960062..102992484 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534308.4 → XP_006534371.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X1

    Conserved Domains (4) summary
    PLN02228
    Location:251 → 777
    PLN02228; Phosphoinositide phospholipase C
    cd13363
    Location:61 → 177
    PH_PLC_delta; Phospholipase C-delta (PLC-delta) pleckstrin homology (PH) domain
    pfam14788
    Location:197 → 246
    EF-hand_10; EF hand
    cl14615
    Location:332 → 626
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

  2. XM_006534309.5 → XP_006534372.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X2

    Conserved Domains (4) summary
    cd08630
    Location:291 → 586
    PI-PLCc_delta3; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-delta3
    PLN02228
    Location:210 → 737
    PLN02228; Phosphoinositide phospholipase C
    cd13363
    Location:20 → 136
    PH_PLC_delta; Phospholipase C-delta (PLC-delta) pleckstrin homology (PH) domain
    pfam14788
    Location:156 → 205
    EF-hand_10; EF hand

  3. XM_017314788.3 → XP_017170277.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X3

    UniProtKB/TrEMBL
    F7AAE0
    Related
    ENSMUSP00000117455.2, ENSMUST00000128650.8
    Conserved Domains (2) summary
    cd00275
    Location:343 → 470
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cl14615
    Location:20 → 314
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K2J0.2 GenPept UniProtKB/Swiss-Prot:Q8K2J0

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