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Zfp131 zinc finger protein 131 [ Mus musculus (house mouse) ]

Gene ID: 72465, updated on 7-Apr-2024

Summary

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Official Symbol
Zfp131provided by MGI
Official Full Name
zinc finger protein 131provided by MGI
Primary source
MGI:MGI:1919715
See related
Ensembl:ENSMUSG00000094870 AllianceGenome:MGI:1919715
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Znf131; 2610109I01Rik
Summary
This gene encodes a member of the BTB/POZ family of transcription factors. This protein has been found to act as a transcriptional activator and may regulate estrogen receptor signaling. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 11.2), CNS E14 (RPKM 8.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
13; 13 D2.3
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (120226722..120253070, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (119765186..119791477, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 Neighboring gene NIM1 serine/threonine protein kinase Neighboring gene predicted gene, 52026 Neighboring gene predicted gene, 41077 Neighboring gene predicted gene, 23308 Neighboring gene Tcstv family member 7A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. BTB-ZF Protein Znf131 Regulates Cell Growth of Developing and Mature T Cells. Iguchi T, et al. J Immunol, 2015 Aug 1. PMID 26136427
  2. A BTB-ZF protein, ZNF131, is required for early B cell development. Iguchi T, et al. Biochem Biophys Res Commun, 2018 Jun 22. PMID 29750959
  3. The POZ-ZF transcription factor Znf131 is implicated as a regulator of Kaiso-mediated biological processes. Robinson SC, et al. Biochem Biophys Res Commun, 2017 Nov 4. PMID 28882591
  4. The murine BTB/POZ zinc finger gene Znf131: predominant expression in the developing central nervous system, in adult brain, testis, and thymus. Trappe R, et al. Biochem Biophys Res Commun, 2002 Aug 16. PMID 12163020
  5. Kaiso regulates Znf131-mediated transcriptional activation. Donaldson NS, et al. Exp Cell Res, 2010 Jun 10. PMID 20303951

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. YAP1-activated ZNF131 promotes hepatocellular carcinoma cell proliferation through transcriptional regulation of PAIP1.
    Title: YAP1-activated ZNF131 promotes hepatocellular carcinoma cell proliferation through transcriptional regulation of PAIP1.
  2. The BTB transcription factors ZBTB11 and ZFP131 maintain pluripotency by repressing pro-differentiation genes.
    Title: The BTB transcription factors ZBTB11 and ZFP131 maintain pluripotency by repressing pro-differentiation genes.
  3. ZNF131 suppresses expression of Cdk inhibitor, p21(cip1), and that of pro-apoptotic factors, Bax and Puma, targets of p53, to facilitate cell cycle progression and suppress unnecessary apoptosis, respectively, of pro-B cells.
    Title: A BTB-ZF protein, ZNF131, is required for early B cell development.
  4. We also demonstrate that Kaiso inhibits Znf131 expression, raising the possibility that Kaiso and Znf131 act to fine-tune target gene expression. Together, our findings implicate Znf131 as a co-regulator of Kaiso-mediated biological processes.
    Title: The POZ-ZF transcription factor Znf131 is implicated as a regulator of Kaiso-mediated biological processes.
  5. Znf131 is critical for T cell development during double-negative to double-positive stage, with which significant cell expansion triggered by the pre-TCR signal is coupled.
    Title: BTB-ZF Protein Znf131 Regulates Cell Growth of Developing and Mature T Cells.
  6. Znf131 is a transcriptional activator, a less common function of POZ-ZF proteins, that is negatively regulated by its heterodimerization partner Kaiso.
    Title: Kaiso regulates Znf131-mediated transcriptional activation.
  7. Results suggest that Znf131/ZNF131 plays a role during development and organogenesis as well as in the function of the adult central nervous system.
    Title: The murine BTB/POZ zinc finger gene Znf131: predominant expression in the developing central nervous system, in adult brain, testis, and thymus.
  8. The mechanism of Znf131 nuclear localization, is reported.
    Title: Nuclear trafficking of the POZ-ZF protein Znf131.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of immune system process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in intermediate filament cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 131
Names
putative transcription factor ZNF131

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001302547.1 → NP_001289476.1  zinc finger protein 131 isoform 1

    See identical proteins and their annotated locations for NP_001289476.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1, also known as long isoform). Variants 1, 3 and 4 encode the same isoform (1).
    Source sequence(s)
    AK011832, AK030398, AK135723, AY092766, BE994245, BP765660
    Consensus CDS
    CCDS79245.1
    UniProtKB/Swiss-Prot
    Q3UYZ4, Q80UU7, Q8C8D0, Q8K3J5, Q9D042
    Conserved Domains (5) summary
    COG5048
    Location:262 → 444
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:290 → 311
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:422 → 439
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18221
    Location:16 → 128
    BTB_POZ_ZBTB35_ZNF131; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131)
    pfam13465
    Location:342 → 367
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001302548.1 → NP_001289477.1  zinc finger protein 131 isoform 2

    See identical proteins and their annotated locations for NP_001289477.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an in-frame portion of the 5' coding region compared to variant 1. Variants 2 and 5 encode the same isoform (2, also known as the short isoform), which is shorter than isoform 1.
    Source sequence(s)
    AK011832, AK030398, AK135723, AK162903, BP765660
    Consensus CDS
    CCDS56903.1
    UniProtKB/Swiss-Prot
    Q8K3J5
    Related
    ENSMUSP00000152941.2, ENSMUST00000223813.2
    Conserved Domains (5) summary
    COG5048
    Location:192 → 410
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:256 → 277
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:388 → 405
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18221
    Location:16 → 128
    BTB_POZ_ZBTB35_ZNF131; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131)
    pfam13465
    Location:308 → 333
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001302549.1 → NP_001289478.1  zinc finger protein 131 isoform 1

    See identical proteins and their annotated locations for NP_001289478.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 3 and 4 encode the same isoform (1, also known as the long isoform).
    Source sequence(s)
    AK011832, AK030398, AK134257, AK135723, BP765660
    Consensus CDS
    CCDS79245.1
    UniProtKB/Swiss-Prot
    Q3UYZ4, Q80UU7, Q8C8D0, Q8K3J5, Q9D042
    Related
    ENSMUSP00000136867.2, ENSMUST00000177916.8
    Conserved Domains (5) summary
    COG5048
    Location:262 → 444
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:290 → 311
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:422 → 439
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18221
    Location:16 → 128
    BTB_POZ_ZBTB35_ZNF131; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131)
    pfam13465
    Location:342 → 367
    zf-H2C2_2; Zinc-finger double domain

  4. NM_001302550.1 → NP_001289479.1  zinc finger protein 131 isoform 1

    See identical proteins and their annotated locations for NP_001289479.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 3 and 4 encode the same isoform (1, also known as the long isoform).
    Source sequence(s)
    AK011832, AK030398, AK135723, BP765660, BY103805
    Consensus CDS
    CCDS79245.1
    UniProtKB/Swiss-Prot
    Q3UYZ4, Q80UU7, Q8C8D0, Q8K3J5, Q9D042
    Related
    ENSMUSP00000153044.2, ENSMUST00000223722.2
    Conserved Domains (5) summary
    COG5048
    Location:262 → 444
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:290 → 311
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:422 → 439
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18221
    Location:16 → 128
    BTB_POZ_ZBTB35_ZNF131; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131)
    pfam13465
    Location:342 → 367
    zf-H2C2_2; Zinc-finger double domain

  5. NM_028245.4 → NP_082521.1  zinc finger protein 131 isoform 2

    See identical proteins and their annotated locations for NP_082521.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and lacks an in-frame portion of the 5' coding region compared to variant 1. Variants 2 and 5 encode the same isoform (2, also known as the short isoform), which is shorter than isoform 1.
    Source sequence(s)
    AK011832, AK030398, AK134257, AK135723, BP765660
    Consensus CDS
    CCDS56903.1
    UniProtKB/Swiss-Prot
    Q8K3J5
    Related
    ENSMUSP00000136019.2, ENSMUST00000178271.3
    Conserved Domains (5) summary
    COG5048
    Location:192 → 410
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:256 → 277
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:388 → 405
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18221
    Location:16 → 128
    BTB_POZ_ZBTB35_ZNF131; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131)
    pfam13465
    Location:308 → 333
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    120226722..120253070 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017315610.3 → XP_017171099.1  zinc finger protein 131 isoform X2

    UniProtKB/Swiss-Prot
    Q8K3J5
    Conserved Domains (5) summary
    COG5048
    Location:192 → 410
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:256 → 277
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:388 → 405
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18221
    Location:16 → 128
    BTB_POZ_ZBTB35_ZNF131; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131)
    pfam13465
    Location:308 → 333
    zf-H2C2_2; Zinc-finger double domain

  2. XM_006517769.4 → XP_006517832.1  zinc finger protein 131 isoform X1

    See identical proteins and their annotated locations for XP_006517832.1

    UniProtKB/Swiss-Prot
    Q3UYZ4, Q80UU7, Q8C8D0, Q8K3J5, Q9D042
    Conserved Domains (5) summary
    COG5048
    Location:262 → 444
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:290 → 311
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:422 → 439
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18221
    Location:16 → 128
    BTB_POZ_ZBTB35_ZNF131; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131)
    pfam13465
    Location:342 → 367
    zf-H2C2_2; Zinc-finger double domain

  3. XM_030247417.2 → XP_030103277.1  zinc finger protein 131 isoform X2

    Conserved Domains (5) summary
    COG5048
    Location:192 → 410
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:256 → 277
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:388 → 405
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18221
    Location:16 → 128
    BTB_POZ_ZBTB35_ZNF131; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131)
    pfam13465
    Location:308 → 333
    zf-H2C2_2; Zinc-finger double domain

  4. XM_006517766.1 → XP_006517829.1  zinc finger protein 131 isoform X1

    See identical proteins and their annotated locations for XP_006517829.1

    UniProtKB/Swiss-Prot
    Q3UYZ4, Q80UU7, Q8C8D0, Q8K3J5, Q9D042
    Conserved Domains (5) summary
    COG5048
    Location:262 → 444
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:290 → 311
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:422 → 439
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18221
    Location:16 → 128
    BTB_POZ_ZBTB35_ZNF131; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131)
    pfam13465
    Location:342 → 367
    zf-H2C2_2; Zinc-finger double domain

  5. XM_011244698.3 → XP_011243000.1  zinc finger protein 131 isoform X3

    Conserved Domains (3) summary
    sd00017
    Location:190 → 211
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:322 → 339
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:242 → 267
    zf-H2C2_2; Zinc-finger double domain

  6. XM_036158183.1 → XP_036014076.1  zinc finger protein 131 isoform X4

    Conserved Domains (3) summary
    sd00017
    Location:156 → 177
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:288 → 305
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:208 → 233
    zf-H2C2_2; Zinc-finger double domain

  7. XM_036158184.1 → XP_036014077.1  zinc finger protein 131 isoform X5

    Conserved Domains (4) summary
    COG5048
    Location:1 → 165
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:11 → 32
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:143 → 160
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:63 → 88
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K3J5.1 GenPept UniProtKB/Swiss-Prot:Q8K3J5

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