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Rhno1 RAD9-HUS1-RAD1 interacting nuclear orphan 1 [ Mus musculus (house mouse) ]

Gene ID: 72440, updated on 11-Apr-2024

Summary

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Official Symbol
Rhno1provided by MGI
Official Full Name
RAD9-HUS1-RAD1 interacting nuclear orphan 1provided by MGI
Primary source
MGI:MGI:1915315
See related
Ensembl:ENSMUSG00000048668 AllianceGenome:MGI:1915315
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2510047L19Rik; 5930416I19Rik
Summary
Predicted to be involved in cellular response to radiation; recombinational repair; and regulation of cell cycle process. Predicted to act upstream of or within cellular response to DNA damage stimulus. Predicted to be active in chromosome and nucleus. Is expressed in midbrain ventricular layer; neural retina; olfactory cortex ventricular layer; renal cortex; and telencephalon ventricular layer. Orthologous to human RHNO1 (RAD9-HUS1-RAD1 interacting nuclear orphan 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 8.3), thymus adult (RPKM 8.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Rhno1 in Genome Data Viewer
Location:
6 F3; 6 62.97 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (128333962..128339876, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (128356999..128362911, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L18, pseudogene 2 Neighboring gene STARR-positive B cell enhancer ABC_E8134 Neighboring gene TUB like protein 3 Neighboring gene STARR-positive B cell enhancer ABC_E4867 Neighboring gene forkhead box M1 Neighboring gene STARR-positive B cell enhancer ABC_E8833 Neighboring gene testis expressed 52 Neighboring gene nuclear receptor interacting protein 2 Neighboring gene integrin alpha FG-GAP repeat containing 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. [RHNO1: A novel noncoding RNA highly expressed in the testis and involved in DNA double-strand break repair]. Gu NH, et al. Zhonghua Nan Ke Xue, 2020 May. PMID 33354946
  2. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. [RHNO1: A novel noncoding RNA highly expressed in the testis and involved in DNA double-strand break repair].
    Title: [RHNO1: A novel noncoding RNA highly expressed in the testis and involved in DNA double-strand break repair].
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chromatin-protein adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in DNA damage checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA damage checkpoint signaling ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to UV ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to ionizing radiation ISO
Inferred from Sequence Orthology
more info
  
involved_in double-strand break repair via alternative nonhomologous end joining ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of G0 to G1 transition ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to site of double-strand break ISO
Inferred from Sequence Orthology
more info
  
involved_in recombinational repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in recombinational repair ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of chromatin ISO
Inferred from Sequence Orthology
more info
  
is_active_in chromosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chromosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in site of double-strand break ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
RAD9, HUS1, RAD1-interacting nuclear orphan protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001326583.1 → NP_001313512.1  RAD9, HUS1, RAD1-interacting nuclear orphan protein 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. All 4 variants encode the same protein.
    Source sequence(s)
    AC116573, AK029454
    Consensus CDS
    CCDS85164.1
    UniProtKB/Swiss-Prot
    Q3U0N5, Q3UK55, Q8K3A4, Q99JS2
    UniProtKB/TrEMBL
    E9Q1D4
    Related
    ENSMUSP00000054573.9, ENSMUST00000057421.15
    Conserved Domains (1) summary
    pfam15319
    Location:1 → 233
    RHINO; RAD9, RAD1, HUS1-interacting nuclear orphan protein

  2. NM_001326585.1 → NP_001313514.1  RAD9, HUS1, RAD1-interacting nuclear orphan protein 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. All 4 variants encode the same protein.
    Source sequence(s)
    AC116573, BB841580, BE655013
    Consensus CDS
    CCDS85164.1
    UniProtKB/Swiss-Prot
    Q3U0N5, Q3UK55, Q8K3A4, Q99JS2
    UniProtKB/TrEMBL
    E9Q1D4
    Related
    ENSMUSP00000107778.2, ENSMUST00000112151.2
    Conserved Domains (1) summary
    pfam15319
    Location:1 → 233
    RHINO; RAD9, RAD1, HUS1-interacting nuclear orphan protein

  3. NM_001326586.1 → NP_001313515.1  RAD9, HUS1, RAD1-interacting nuclear orphan protein 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript. All 4 variants encode the same protein.
    Source sequence(s)
    AC116573
    Consensus CDS
    CCDS85164.1
    UniProtKB/Swiss-Prot
    Q3U0N5, Q3UK55, Q8K3A4, Q99JS2
    UniProtKB/TrEMBL
    E9Q1D4
    Related
    ENSMUSP00000107779.2, ENSMUST00000112152.8
    Conserved Domains (1) summary
    pfam15319
    Location:1 → 233
    RHINO; RAD9, RAD1, HUS1-interacting nuclear orphan protein

  4. NM_001326587.1 → NP_001313516.1  RAD9, HUS1, RAD1-interacting nuclear orphan protein 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 3. All 4 variants encode the same protein.
    Source sequence(s)
    AC116573
    Consensus CDS
    CCDS85164.1
    UniProtKB/Swiss-Prot
    Q3U0N5, Q3UK55, Q8K3A4, Q99JS2
    UniProtKB/TrEMBL
    E9Q1D4
    Conserved Domains (1) summary
    pfam15319
    Location:1 → 233
    RHINO; RAD9, RAD1, HUS1-interacting nuclear orphan protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    128333962..128339876 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152323.1 → XP_036008216.1  RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q3U0N5, Q3UK55, Q8K3A4, Q99JS2
    UniProtKB/TrEMBL
    E9Q1D4
    Conserved Domains (1) summary
    pfam15319
    Location:1 → 233
    RHINO; RAD9, RAD1, HUS1-interacting nuclear orphan protein

  2. XM_017321763.2 → XP_017177252.1  RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q3U0N5, Q3UK55, Q8K3A4, Q99JS2
    UniProtKB/TrEMBL
    E9Q1D4
    Conserved Domains (1) summary
    pfam15319
    Location:1 → 233
    RHINO; RAD9, RAD1, HUS1-interacting nuclear orphan protein

  3. XM_036152322.1 → XP_036008215.1  RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q3U0N5, Q3UK55, Q8K3A4, Q99JS2
    UniProtKB/TrEMBL
    E9Q1D4
    Conserved Domains (1) summary
    pfam15319
    Location:1 → 233
    RHINO; RAD9, RAD1, HUS1-interacting nuclear orphan protein

  4. XM_036152321.1 → XP_036008214.1  RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q3U0N5, Q3UK55, Q8K3A4, Q99JS2
    UniProtKB/TrEMBL
    E9Q1D4
    Conserved Domains (1) summary
    pfam15319
    Location:1 → 233
    RHINO; RAD9, RAD1, HUS1-interacting nuclear orphan protein

  5. XM_017321762.3 → XP_017177251.1  RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q3U0N5, Q3UK55, Q8K3A4, Q99JS2
    UniProtKB/TrEMBL
    E9Q1D4
    Related
    ENSMUSP00000152251.2, ENSMUST00000223237.2
    Conserved Domains (1) summary
    pfam15319
    Location:1 → 233
    RHINO; RAD9, RAD1, HUS1-interacting nuclear orphan protein

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_197981.1: Suppressed sequence

    Description
    NM_197981.1: This RefSeq was permanently suppressed because it is now thought that this gene does not encode a protein.

  2. NR_027359.1: Suppressed sequence

    Description
    NR_027359.1: This RefSeq was removed because it is now thought that this gene does encode a protein.

  3. NR_027360.1: Suppressed sequence

    Description
    NR_027360.1: This RefSeq was removed because it is now thought that this gene does encode a protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K3A4.1 GenPept UniProtKB/Swiss-Prot:Q8K3A4

Gene LinkOut

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Chemical Information
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