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Kcnmb2 potassium large conductance calcium-activated channel, subfamily M, beta member 2 [ Mus musculus (house mouse) ]

Gene ID: 72413, updated on 21-Apr-2024

Summary

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Official Symbol
Kcnmb2provided by MGI
Official Full Name
potassium large conductance calcium-activated channel, subfamily M, beta member 2provided by MGI
Primary source
MGI:MGI:1919663
See related
Ensembl:ENSMUSG00000037610 AllianceGenome:MGI:1919663
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2700049B16Rik; 3110031N04Rik
Summary
Predicted to enable calcium-activated potassium channel activity and potassium channel regulator activity. Predicted to be involved in detection of calcium ion; neuronal action potential; and potassium ion transport. Predicted to act upstream of or within ion transport. Predicted to be integral component of plasma membrane. Predicted to be part of voltage-gated potassium channel complex. Is expressed in ascending aorta and ductus arteriosus. Orthologous to human KCNMB2 (potassium calcium-activated channel subfamily M regulatory beta subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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Location:
3 A3; 3 15.48 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (31956021..32254329)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (31901861..32200180)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_07327 Neighboring gene predicted gene, 54171 Neighboring gene predicted gene 6558 Neighboring gene STARR-seq mESC enhancer starr_07328 Neighboring gene predicted gene, 33886 Neighboring gene predicted gene, 34031 Neighboring gene STARR-seq mESC enhancer starr_07329 Neighboring gene STARR-seq mESC enhancer starr_07330 Neighboring gene STARR-seq mESC enhancer starr_07331 Neighboring gene STARR-seq mESC enhancer starr_07332 Neighboring gene predicted gene, 42201 Neighboring gene predicted gene, 37770 Neighboring gene predicted gene, 57708

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Hyperaldosteronism after decreased renal K+ excretion in KCNMB2 knockout mice. Larsen CK, et al. Am J Physiol Renal Physiol, 2016 May 15. PMID 26962098
  2. Intact colonic K(C)(a)1.1 channel activity in KCNMB2 knockout mice. Larsen CK, et al. Physiol Rep, 2017 Mar. PMID 28292889, Free PMC Article
  3. BK channel inactivation gates daytime excitability in the circadian clock. Whitt JP, et al. Nat Commun, 2016 Mar 4. PMID 26940770, Free PMC Article
  4. Knockout of the BK β2 subunit abolishes inactivation of BK currents in mouse adrenal chromaffin cells and results in slow-wave burst activity. Martinez-Espinosa PL, et al. J Gen Physiol, 2014 Oct. PMID 25267913, Free PMC Article
  5. Transcriptional profiling reveals ductus arteriosus-specific genes that regulate vascular tone. Shelton EL, et al. Physiol Genomics, 2014 Jul 1. PMID 24790087, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Clone Names

  • MGC57945

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium-activated potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-activated potassium channel activity ISO
Inferred from Sequence Orthology
more info
  
enables potassium channel activity ISO
Inferred from Sequence Orthology
more info
  
enables potassium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in action potential ISO
Inferred from Sequence Orthology
more info
  
involved_in detection of calcium ion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in detection of calcium ion ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in neuronal action potential ISO
Inferred from Sequence Orthology
more info
  
involved_in potassium ion transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of voltage-gated potassium channel complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
calcium-activated potassium channel subunit beta-2
Names
BK channel subunit beta-2
BKbeta2
calcium-activated potassium channel, subfamily M subunit beta-2
charybdotoxin receptor subunit beta-2
k(VCA)beta-2
maxi K channel subunit beta-2
slo-beta-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001429175.1 → NP_001416104.1  calcium-activated potassium channel subunit beta-2

    Status: VALIDATED

    Source sequence(s)
    AC115930, AC156552, AC158571

  2. NM_028231.3 → NP_082507.1  calcium-activated potassium channel subunit beta-2

    See identical proteins and their annotated locations for NP_082507.1

    Status: VALIDATED

    Source sequence(s)
    AC115930, AC156552, AC158571
    Consensus CDS
    CCDS17292.1
    UniProtKB/Swiss-Prot
    Q9CZM9
    Related
    ENSMUSP00000113234.2, ENSMUST00000119970.8
    Conserved Domains (2) summary
    pfam03185
    Location:38 → 229
    CaKB; Calcium-activated potassium channel, beta subunit
    pfam09303
    Location:2 → 32
    KcnmB2_inactiv; KCNMB2, ball and chain domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    31956021..32254329
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006535550.3 → XP_006535613.1  calcium-activated potassium channel subunit beta-2 isoform X2

    See identical proteins and their annotated locations for XP_006535613.1

    UniProtKB/Swiss-Prot
    Q9CZM9
    Conserved Domains (2) summary
    pfam03185
    Location:38 → 229
    CaKB; Calcium-activated potassium channel, beta subunit
    pfam09303
    Location:2 → 32
    KcnmB2_inactiv; KCNMB2, ball and chain domain

  2. XM_006535549.5 → XP_006535612.1  calcium-activated potassium channel subunit beta-2 isoform X2

    UniProtKB/Swiss-Prot
    Q9CZM9
    Related
    ENSMUSP00000112531.2, ENSMUST00000119310.8
    Conserved Domains (2) summary
    pfam03185
    Location:38 → 229
    CaKB; Calcium-activated potassium channel, beta subunit
    pfam09303
    Location:2 → 32
    KcnmB2_inactiv; KCNMB2, ball and chain domain

  3. XM_006535548.5 → XP_006535611.1  calcium-activated potassium channel subunit beta-2 isoform X1

    Conserved Domains (2) summary
    pfam09303
    Location:31 → 61
    KcnmB2_inactiv; KCNMB2, ball and chain domain
    pfam03185
    Location:67 → 258
    CaKB; Calcium-activated potassium channel, beta subunit

  4. XM_036163350.1 → XP_036019243.1  calcium-activated potassium channel subunit beta-2 isoform X2

    UniProtKB/Swiss-Prot
    Q9CZM9
    Conserved Domains (2) summary
    pfam03185
    Location:38 → 229
    CaKB; Calcium-activated potassium channel, beta subunit
    pfam09303
    Location:2 → 32
    KcnmB2_inactiv; KCNMB2, ball and chain domain

  5. XM_006535551.4 → XP_006535614.1  calcium-activated potassium channel subunit beta-2 isoform X2

    See identical proteins and their annotated locations for XP_006535614.1

    UniProtKB/Swiss-Prot
    Q9CZM9
    Conserved Domains (2) summary
    pfam03185
    Location:38 → 229
    CaKB; Calcium-activated potassium channel, beta subunit
    pfam09303
    Location:2 → 32
    KcnmB2_inactiv; KCNMB2, ball and chain domain

  6. XM_017319742.3 → XP_017175231.1  calcium-activated potassium channel subunit beta-2 isoform X2

    UniProtKB/Swiss-Prot
    Q9CZM9
    Conserved Domains (2) summary
    pfam03185
    Location:38 → 229
    CaKB; Calcium-activated potassium channel, beta subunit
    pfam09303
    Location:2 → 32
    KcnmB2_inactiv; KCNMB2, ball and chain domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CZM9.1 GenPept UniProtKB/Swiss-Prot:Q9CZM9

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