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Pinx1 PIN2/TERF1 interacting, telomerase inhibitor 1 [ Mus musculus (house mouse) ]

Gene ID: 72400, updated on 21-Apr-2024

Summary

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Official Symbol
Pinx1provided by MGI
Official Full Name
PIN2/TERF1 interacting, telomerase inhibitor 1provided by MGI
Primary source
MGI:MGI:1919650
See related
Ensembl:ENSMUSG00000021958 AllianceGenome:MGI:1919650
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LPTS; LPTS1; 67-11-3; 2210403I16Rik; 2610028A01Rik
Summary
Predicted to enable telomerase RNA binding activity and telomerase inhibitor activity. Predicted to be involved in several processes, including negative regulation of DNA biosynthetic process; positive regulation of protein localization to nucleolus; and protein localization to organelle. Predicted to act upstream of or within telomere maintenance via telomerase. Predicted to be located in several cellular components, including chromosomal region; nuclear lumen; and spindle. Is expressed in several structures, including brain; liver; mammary gland; sensory organ; and trigeminal ganglion. Orthologous to human PINX1 (PIN2 (TERF1) interacting telomerase inhibitor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 10.0), CNS E14 (RPKM 4.6) and 21 other tissues See more
Orthologs
human all
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Genomic context

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Location:
14 D1; 14 33.34 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (64097728..64157311)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (63860277..63919862)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene X-linked Kx blood group related 6 Neighboring gene predicted gene, 36218 Neighboring gene STARR-seq mESC enhancer starr_36932 Neighboring gene predicted gene, 41175 Neighboring gene RIKEN cDNA 4930578I06 gene Neighboring gene SRY (sex determining region Y)-box 7 Neighboring gene predicted gene, 36410

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. PinX1t, a Novel PinX1 Transcript Variant, Positively Regulates Cardiogenesis of Embryonic Stem Cells. Chan HC, et al. J Am Heart Assoc, 2020 Mar 17. PMID 32157956, Free PMC Article
  2. [The cloning and expression of a novel mouse gene mLPTS and its subcellular localization]. Liao C, et al. Yi Chuan Xue Bao, 2002 Oct. PMID 12561469
  3. PinX1 Depletion Improves Liver Injury in a Mouse Model of Nonalcoholic Fatty Liver Disease via Increasing Telomerase Activity and Inhibiting Apoptosis. Huang E, et al. Cytogenet Genome Res, 2021. PMID 34657040
  4. The telomerase inhibitor PinX1 is a major haploinsufficient tumor suppressor essential for chromosome stability in mice. Zhou XZ, et al. J Clin Invest, 2011 Apr. PMID 21436583, Free PMC Article
  5. The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor. Zhou XZ, et al. Cell, 2001 Nov 2. PMID 11701125

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PinX1 Depletion Improves Liver Injury in a Mouse Model of Nonalcoholic Fatty Liver Disease via Increasing Telomerase Activity and Inhibiting Apoptosis.
    Title: PinX1 Depletion Improves Liver Injury in a Mouse Model of Nonalcoholic Fatty Liver Disease via Increasing Telomerase Activity and Inhibiting Apoptosis.
  2. PinX1t, a Novel PinX1 Transcript Variant, Positively Regulates Cardiogenesis of Embryonic Stem Cells.
    Title: PinX1t, a Novel PinX1 Transcript Variant, Positively Regulates Cardiogenesis of Embryonic Stem Cells.
  3. PinX1 heterozygosity and PinX1 knockdown in mouse embryonic fibroblasts activated telomerase and led to concomitant telomerase-dependent chromosomal instability.
    Title: The telomerase inhibitor PinX1 is a major haploinsufficient tumor suppressor essential for chromosome stability in mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC144540

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
enables telomerase RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables telomerase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables telomerase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in mitotic metaphase chromosome alignment ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of G2/M transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of telomerase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of telomere maintenance via telomerase ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein localization to nucleolus ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of telomeric DNA binding ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to nucleolus ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein stability ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within telomere maintenance via telomerase ISO
Inferred from Sequence Orthology
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear chromosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in spindle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
PIN2/TERF1-interacting telomerase inhibitor 1
Names
PIN2-interacting protein X1
PIN2/TRF1-interacting protein
TRF1-interacting protein 1
liver-related putative tumor suppressor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028228.4 → NP_082504.1  PIN2/TERF1-interacting telomerase inhibitor 1

    See identical proteins and their annotated locations for NP_082504.1

    Status: VALIDATED

    Source sequence(s)
    AC118607, AC161764
    Consensus CDS
    CCDS27205.1
    UniProtKB/Swiss-Prot
    Q14BS4, Q3V450, Q8C6E5, Q91WZ9, Q9CZX5, Q9D0C2
    Related
    ENSMUSP00000022528.5, ENSMUST00000022528.6
    Conserved Domains (1) summary
    smart00443
    Location:24 → 69
    G_patch; glycine rich nucleic binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    64097728..64157311
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006519595.5 → XP_006519658.1  PIN2/TERF1-interacting telomerase inhibitor 1 isoform X1

    Conserved Domains (1) summary
    smart00443
    Location:24 → 69
    G_patch; glycine rich nucleic binding domain

  2. XM_030248045.2 → XP_030103905.1  PIN2/TERF1-interacting telomerase inhibitor 1 isoform X2

  3. XM_036158856.1 → XP_036014749.1  PIN2/TERF1-interacting telomerase inhibitor 1 isoform X3

RNA

  1. XR_003950903.2 RNA Sequence

  2. XR_004938457.1 RNA Sequence

  3. XR_383213.5 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CZX5.2 GenPept UniProtKB/Swiss-Prot:Q9CZX5

Gene LinkOut

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