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Tmem175 transmembrane protein 175 [ Mus musculus (house mouse) ]

Gene ID: 72392, updated on 5-Mar-2024

Summary

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Official Symbol
Tmem175provided by MGI
Official Full Name
transmembrane protein 175provided by MGI
Primary source
MGI:MGI:1919642
See related
Ensembl:ENSMUSG00000013495 AllianceGenome:MGI:1919642
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mTMEM175; 3010001K23Rik
Summary
Enables potassium ion leak channel activity. Involved in lysosome organization; neuron cellular homeostasis; and potassium ion transmembrane transport. Predicted to be integral component of endosome membrane and integral component of lysosomal membrane. Predicted to be active in endosome and lysosome. Orthologous to human TMEM175 (transmembrane protein 175). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 32.5), ovary adult (RPKM 20.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 F; 5 53.24 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (108777649..108795636)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (108629779..108647770)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_13909 Neighboring gene complexin 1 Neighboring gene cyclin G associated kinase Neighboring gene diacylglycerol kinase, theta Neighboring gene iduronidase, alpha-L Neighboring gene solute carrier family 26 (sulfate transporter), member 1 Neighboring gene predicted gene, 42151

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Lysosomal K(+) channel TMEM175 promotes apoptosis and aggravates symptoms of Parkinson's disease. Qu L, et al. EMBO Rep, 2022 Sep 5. PMID 35913019, Free PMC Article
  2. Translocation of TMEM175 Lysosomal Potassium Channel to the Plasma Membrane by Dynasore Compounds. Pergel E, et al. Int J Mol Sci, 2021 Sep 29. PMID 34638858, Free PMC Article
  3. Parkinson's disease-risk protein TMEM175 is a proton-activated proton channel in lysosomes. Hu M, et al. Cell, 2022 Jun 23. PMID 35750034, Free PMC Article
  4. A growth-factor-activated lysosomal K(+) channel regulates Parkinson's pathology. Wie J, et al. Nature, 2021 Mar. PMID 33505021, Free PMC Article
  5. Identification of novel markers of mouse fetal ovary development. Chen H, et al. PLoS One, 2012. PMID 22844512, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Lysosomal K(+) channel TMEM175 promotes apoptosis and aggravates symptoms of Parkinson's disease.
    Title: Lysosomal K(+) channel TMEM175 promotes apoptosis and aggravates symptoms of Parkinson's disease.
  2. Translocation of TMEM175 Lysosomal Potassium Channel to the Plasma Membrane by Dynasore Compounds.
    Title: Translocation of TMEM175 Lysosomal Potassium Channel to the Plasma Membrane by Dynasore Compounds.
  3. TMEM175 comprises a potassium (K) channel that underlies the molecular mechanism of lysosomal K(+) permeability.
    Title: TMEM175 Is an Organelle K(+) Channel Regulating Lysosomal Function.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (4)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables arachidonic acid binding ISO
Inferred from Sequence Orthology
more info
  
enables potassium channel activity ISO
Inferred from Sequence Orthology
more info
  
enables potassium ion leak channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables potassium ion leak channel activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables potassium ion leak channel activity ISO
Inferred from Sequence Orthology
more info
  
enables proton channel activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in lysosomal lumen pH elevation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in neuron cellular homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phagosome-lysosome fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in potassium ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within potassium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in proton transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of lysosomal lumen pH IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of lysosomal lumen pH ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome ISO
Inferred from Sequence Orthology
more info
  
located_in endosome membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosome ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
endosomal/lysosomal proton channel TMEM175
Names
endosomal/lysomomal potassium channel TMEM175
endosomal/lysosomal potassium channel TMEM175
potassium channel TMEM175

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163531.1 → NP_001157003.1  endosomal/lysosomal proton channel TMEM175 isoform 2

    See identical proteins and their annotated locations for NP_001157003.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice junction compared to variant 4. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
    Source sequence(s)
    AK034579, BB653267
    UniProtKB/TrEMBL
    Q8BM80
    Conserved Domains (1) summary
    pfam06736
    Location:256 → 352
    DUF1211; Protein of unknown function (DUF1211)

  2. NM_001163532.1 → NP_001157004.1  endosomal/lysosomal proton channel TMEM175 isoform 1

    See identical proteins and their annotated locations for NP_001157004.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 4. Variants 1, 3, and 4 all encode the same isoform (1).
    Source sequence(s)
    AI526594, AK013879, AK034579, BB653267
    Consensus CDS
    CCDS19514.1
    UniProtKB/Swiss-Prot
    Q3TDC4, Q99K00, Q9CXY1
    Related
    ENSMUSP00000068607.7, ENSMUST00000063272.13
    Conserved Domains (1) summary
    pfam06736
    Location:257 → 353
    DUF1211; Protein of unknown function (DUF1211)

  3. NM_001359423.1 → NP_001346352.1  endosomal/lysosomal proton channel TMEM175 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (1). Variants 1, 3, and 4 all encode the same isoform (1).
    Source sequence(s)
    AC161813
    Consensus CDS
    CCDS19514.1
    UniProtKB/Swiss-Prot
    Q3TDC4, Q99K00, Q9CXY1
    Related
    ENSMUSP00000112780.2, ENSMUST00000120327.3
    Conserved Domains (1) summary
    pfam06736
    Location:257 → 353
    DUF1211; Protein of unknown function (DUF1211)

  4. NM_001359426.1 → NP_001346355.1  endosomal/lysosomal proton channel TMEM175 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 4. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC161813
    Conserved Domains (1) summary
    pfam06736
    Location:178 → 274
    DUF1211; Protein of unknown function (DUF1211)

  5. NM_001359427.1 → NP_001346356.1  endosomal/lysosomal proton channel TMEM175 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 4. The resulting isoform (4) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC161813, BU057278
    Conserved Domains (1) summary
    pfam06736
    Location:144 → 240
    DUF1211; Protein of unknown function (DUF1211)

  6. NM_028223.3 → NP_082499.3  endosomal/lysosomal proton channel TMEM175 isoform 1

    See identical proteins and their annotated locations for NP_082499.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 4. Variants 1, 3, and 4 all encode the same isoform (1).
    Source sequence(s)
    AK013879, AK034579, BB653267, BY323049, DN175171
    Consensus CDS
    CCDS19514.1
    UniProtKB/Swiss-Prot
    Q3TDC4, Q99K00, Q9CXY1
    Related
    ENSMUSP00000077437.7, ENSMUST00000078323.13
    Conserved Domains (1) summary
    pfam06736
    Location:257 → 353
    DUF1211; Protein of unknown function (DUF1211)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    108777649..108795636
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006535230.5 → XP_006535293.1  endosomal/lysosomal proton channel TMEM175 isoform X1

    See identical proteins and their annotated locations for XP_006535293.1

    UniProtKB/Swiss-Prot
    Q3TDC4, Q99K00, Q9CXY1
    Conserved Domains (1) summary
    pfam06736
    Location:257 → 353
    DUF1211; Protein of unknown function (DUF1211)

  2. XM_006535232.4 → XP_006535295.1  endosomal/lysosomal proton channel TMEM175 isoform X2

    See identical proteins and their annotated locations for XP_006535295.1

    Conserved Domains (1) summary
    pfam06736
    Location:229 → 325
    DUF1211; Protein of unknown function (DUF1211)

  3. XM_036165524.1 → XP_036021417.1  endosomal/lysosomal proton channel TMEM175 isoform X3

    Conserved Domains (1) summary
    pfam06736
    Location:144 → 240
    DUF1211; Protein of unknown function (DUF1211)

  4. XM_036165526.1 → XP_036021419.1  endosomal/lysosomal proton channel TMEM175 isoform X4

    Conserved Domains (1) summary
    pfam06736
    Location:116 → 212
    DUF1211; Protein of unknown function (DUF1211)

  5. XM_006535233.4 → XP_006535296.1  endosomal/lysosomal proton channel TMEM175 isoform X2

    See identical proteins and their annotated locations for XP_006535296.1

    Conserved Domains (1) summary
    pfam06736
    Location:229 → 325
    DUF1211; Protein of unknown function (DUF1211)

  6. XM_030254826.2 → XP_030110686.1  endosomal/lysosomal proton channel TMEM175 isoform X3

    Conserved Domains (1) summary
    pfam06736
    Location:144 → 240
    DUF1211; Protein of unknown function (DUF1211)

  7. XM_030254827.2 → XP_030110687.1  endosomal/lysosomal proton channel TMEM175 isoform X4

    Conserved Domains (1) summary
    pfam06736
    Location:116 → 212
    DUF1211; Protein of unknown function (DUF1211)

  8. XM_036165523.1 → XP_036021416.1  endosomal/lysosomal proton channel TMEM175 isoform X1

    UniProtKB/Swiss-Prot
    Q3TDC4, Q99K00, Q9CXY1
    Conserved Domains (1) summary
    pfam06736
    Location:257 → 353
    DUF1211; Protein of unknown function (DUF1211)

  9. XM_006535237.4 → XP_006535300.1  endosomal/lysosomal proton channel TMEM175 isoform X6

    UniProtKB/TrEMBL
    Q8BHJ8
    Conserved Domains (1) summary
    pfam06736
    Location:32 → 121
    DUF1211; Protein of unknown function (DUF1211)

  10. XM_006535236.3 → XP_006535299.1  endosomal/lysosomal proton channel TMEM175 isoform X5

    Conserved Domains (1) summary
    pfam06736
    Location:16 → 112
    DUF1211; Protein of unknown function (DUF1211)

RNA

  1. XR_004942569.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CXY1.2 GenPept UniProtKB/Swiss-Prot:Q9CXY1

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