Ttc4 tetratricopeptide repeat domain 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ttc4provided by MGI
Official Full Name: tetratricopeptide repeat domain 4provided by MGI
Primary source: MGI:MGI:1919604
See related: Ensembl:ENSMUSG00000025413 AllianceGenome:MGI:1919604
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: L62; 2810002P21Rik
Summary: Predicted to enable Hsp90 protein binding activity. Predicted to be involved in defense response to virus and innate immune response. Predicted to act upstream of or within immune system process. Located in cytoplasm and nucleus. Is expressed in central nervous system; ganglia; olfactory epithelium; renal cortex; and thymus primordium. Orthologous to human TTC4 (tetratricopeptide repeat domain 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 33.7), CNS E18 (RPKM 31.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 C7; 4 49.68 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (106514952..106536188, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (106656806..106679002, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Studies identi fi ed a novel signal of nuclear localization (NLS) in all MSL1 protein isoforms and found that the combination of both NLS allows for its intra-nuclear focal accumulation and nuclear transport of TTC4 while all MSL1 isoforms affect H4K16Ac.
Title: Two distinct nuclear localization signals in mammalian MSL1 regulate its function.
The nuclear transport of TTC4 is apparently a complex process dependent on interactions with other proteins during the progression of the cell cycle.
Title: Nuclear transport of protein TTC4 depends on the cell cycle.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables Hsp70 protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables Hsp90 protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in defense response to virus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	ISO Inferred from Sequence Orthology more info
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tetratricopeptide repeat protein 4

Names: TPR repeat protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001172073.1 → NP_001165544.1 tetratricopeptide repeat protein 4 isoform 2

See identical proteins and their annotated locations for NP_001165544.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR and uses a downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AK005923, AK133931

UniProtKB/TrEMBL

Q3UZC4

Related

ENSMUST00000142342.8

Conserved Domains (2) summary

TIGR00990
Location:28 → 173

3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)

sd00006
Location:34 → 62

TPR; TPR repeat [structural motif]
NM_028209.2 → NP_082485.1 tetratricopeptide repeat protein 4 isoform 1

See identical proteins and their annotated locations for NP_082485.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (1).

Source sequence(s)

AK005923, AK012652, AK133931, BY060470

Consensus CDS

CCDS18424.1

UniProtKB/Swiss-Prot

Q8R3H9

UniProtKB/TrEMBL

Q3UZC4

Related

ENSMUSP00000026480.7, ENSMUST00000026480.13

Conserved Domains (2) summary

sd00006
Location:79 → 107

TPR; TPR repeat [structural motif]

pfam13414
Location:78 → 148

TPR_11; TPR repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

106514952..106536188 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006503408.5 → XP_006503471.1 tetratricopeptide repeat protein 4 isoform X1

UniProtKB/TrEMBL

Q3UZC4

Conserved Domains (2) summary

TIGR00990
Location:73 → 218

3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)

sd00006
Location:79 → 107

TPR; TPR repeat [structural motif]
XM_036164455.1 → XP_036020348.1 tetratricopeptide repeat protein 4 isoform X3

Conserved Domains (1) summary

pfam18972
Location:71 → 155

Wheel; Cns1/TTC4 Wheel domain
XM_006503409.5 → XP_006503472.1 tetratricopeptide repeat protein 4 isoform X2

UniProtKB/TrEMBL

Q3UZC4

Conserved Domains (2) summary

TIGR00990
Location:28 → 173

3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)

sd00006
Location:34 → 62

TPR; TPR repeat [structural motif]