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Usp36 ubiquitin specific peptidase 36 [ Mus musculus (house mouse) ]

Gene ID: 72344, updated on 11-Apr-2024

Summary

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Official Symbol
Usp36provided by MGI
Official Full Name
ubiquitin specific peptidase 36provided by MGI
Primary source
MGI:MGI:1919594
See related
Ensembl:ENSMUSG00000033909 AllianceGenome:MGI:1919594
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1453; 2700002L06Rik
Summary
Predicted to enable cysteine-type endopeptidase activity and thiol-dependent deubiquitinase. Involved in several processes, including protein deubiquitination; protein stabilization; and regulation of rRNA processing. Predicted to be located in cytoplasm; nuclear speck; and nucleolus. Predicted to be active in cytosol and nucleus. Orthologous to human USP36 (ubiquitin specific peptidase 36). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 8.8), limb E14.5 (RPKM 8.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 E2; 11 83.06 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (118150477..118181086, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (118259651..118290260, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_31297 Neighboring gene predicted gene, 38514 Neighboring gene STARR-positive B cell enhancer mm9_chr11:118017777-118018078 Neighboring gene cytohesin 1 Neighboring gene STARR-positive B cell enhancer ABC_E7106 Neighboring gene STARR-positive B cell enhancer ABC_E9850 Neighboring gene VISTA enhancer mm1622 Neighboring gene STARR-positive B cell enhancer ABC_E5309 Neighboring gene STARR-positive B cell enhancer mm9_chr11:118109942-118110243 Neighboring gene STARR-positive B cell enhancer ABC_E9851 Neighboring gene STARR-positive B cell enhancer ABC_E1852 Neighboring gene STARR-seq mESC enhancer starr_31299 Neighboring gene tissue inhibitor of metalloproteinase 2 Neighboring gene CEP295 N-terminal like Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:118209837-118210038 Neighboring gene lectin, galactoside-binding, soluble, 3 binding protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Loss of the deubiquitinase USP36 destabilizes the RNA helicase DHX33 and causes preimplantation lethality in mice. Fraile JM, et al. J Biol Chem, 2018 Feb 9. PMID 29273634, Free PMC Article
  2. Ubiquitin-specific Protease 36 (USP36) Controls Neuronal Precursor Cell-expressed Developmentally Down-regulated 4-2 (Nedd4-2) Actions over the Neurotrophin Receptor TrkA and Potassium Voltage-gated Channels 7.2/3 (Kv7.2/3). Anta B, et al. J Biol Chem, 2016 Sep 2. PMID 27445338, Free PMC Article
  3. The deubiquitinase USP36 promotes snoRNP group SUMOylation and is essential for ribosome biogenesis. Ryu H, et al. EMBO Rep, 2021 Jun 4. PMID 33852194, Free PMC Article
  4. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
  5. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Usp36 is essential for cell and organism viability because of its role in ribosomal RNA processing and protein synthesis, which is mediated, at least in part, by regulating DHX33 stability.
    Title: Loss of the deubiquitinase USP36 destabilizes the RNA helicase DHX33 and causes preimplantation lethality in mice.
  2. USP36 actions extend beyond TrkA because the presence of USP36 interferes with Nedd4-2-dependent Kv7.2/3 channel regulation.
    Title: Ubiquitin-specific Protease 36 (USP36) Controls Neuronal Precursor Cell-expressed Developmentally Down-regulated 4-2 (Nedd4-2) Actions over the Neurotrophin Receptor TrkA and Potassium Voltage-gated Channels 7.2/3 (Kv7.2/3).
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables K48-linked deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2B deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromatin organization ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of macroautophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in nucleolus organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein deubiquitination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein deubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein stabilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of protein stability ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of rRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of rRNA processing ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ubiquitin carboxyl-terminal hydrolase 36
Names
deubiquitinating enzyme 36
ubiquitin specific protease 36
ubiquitin thioesterase 36
ubiquitin-specific-processing protease 36
NP_001028700.1
XP_006534365.1
XP_006534366.1
XP_006534367.1
XP_011247575.1
XP_036012905.1
XP_036012906.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033528.1 → NP_001028700.1  ubiquitin carboxyl-terminal hydrolase 36

    See identical proteins and their annotated locations for NP_001028700.1

    Status: VALIDATED

    Source sequence(s)
    AL591404
    Consensus CDS
    CCDS48998.1
    UniProtKB/Swiss-Prot
    B1AQJ2, Q6ZPQ7
    UniProtKB/TrEMBL
    B0QZF8
    Related
    ENSMUSP00000090036.4, ENSMUST00000092382.10
    Conserved Domains (2) summary
    PHA03247
    Location:479 → 989
    PHA03247; large tegument protein UL36; Provisional
    cd02661
    Location:121 → 421
    Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    118150477..118181086 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534303.2 → XP_006534366.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X1

    See identical proteins and their annotated locations for XP_006534366.1

    UniProtKB/Swiss-Prot
    B1AQJ2, Q6ZPQ7
    UniProtKB/TrEMBL
    B0QZF8
    Conserved Domains (2) summary
    PHA03247
    Location:479 → 989
    PHA03247; large tegument protein UL36; Provisional
    cd02661
    Location:121 → 421
    Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

  2. XM_006534304.5 → XP_006534367.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X1

    See identical proteins and their annotated locations for XP_006534367.1

    UniProtKB/Swiss-Prot
    B1AQJ2, Q6ZPQ7
    UniProtKB/TrEMBL
    B0QZF8
    Conserved Domains (2) summary
    PHA03247
    Location:479 → 989
    PHA03247; large tegument protein UL36; Provisional
    cd02661
    Location:121 → 421
    Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

  3. XM_036157013.1 → XP_036012906.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X2

    Conserved Domains (2) summary
    PHA03247
    Location:508 → 1018
    PHA03247; large tegument protein UL36; Provisional
    cd02661
    Location:150 → 450
    Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

  4. XM_036157012.1 → XP_036012905.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X1

    UniProtKB/Swiss-Prot
    B1AQJ2, Q6ZPQ7
    UniProtKB/TrEMBL
    B0QZF8
    Conserved Domains (2) summary
    PHA03247
    Location:479 → 989
    PHA03247; large tegument protein UL36; Provisional
    cd02661
    Location:121 → 421
    Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

  5. XM_011249273.2 → XP_011247575.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X3

    Conserved Domains (1) summary
    PHA03247
    Location:6 → 516
    PHA03247; large tegument protein UL36; Provisional

  6. XM_006534302.5 → XP_006534365.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X1

    See identical proteins and their annotated locations for XP_006534365.1

    UniProtKB/Swiss-Prot
    B1AQJ2, Q6ZPQ7
    UniProtKB/TrEMBL
    B0QZF8
    Related
    ENSMUSP00000101903.3, ENSMUST00000106296.9
    Conserved Domains (2) summary
    PHA03247
    Location:479 → 989
    PHA03247; large tegument protein UL36; Provisional
    cd02661
    Location:121 → 421
    Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

RNA

  1. XR_004937040.1 RNA Sequence

  2. XR_004937041.1 RNA Sequence

  3. XR_388534.5 RNA Sequence

  4. XR_003949510.1 RNA Sequence

  5. XR_004937039.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B1AQJ2.1 GenPept UniProtKB/Swiss-Prot:B1AQJ2

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