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Plxdc1 plexin domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 72324, updated on 5-Mar-2024

Summary

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Official Symbol
Plxdc1provided by MGI
Official Full Name
plexin domain containing 1provided by MGI
Primary source
MGI:MGI:1919574
See related
Ensembl:ENSMUSG00000017417 AllianceGenome:MGI:1919574
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tem7; 2410003I07Rik
Summary
Predicted to be involved in angiogenesis. Located in cytoplasm and plasma membrane. Orthologous to human PLXDC1 (plexin domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 22.2), thymus adult (RPKM 19.3) and 12 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 D; 11 61.31 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (97814063..97879393, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (97923237..97986669, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA B230217C12 gene Neighboring gene STARR-seq mESC enhancer starr_30642 Neighboring gene F-box protein 47 Neighboring gene STARR-seq mESC enhancer starr_30643 Neighboring gene STARR-positive B cell enhancer ABC_E3011 Neighboring gene STARR-seq mESC enhancer starr_30644 Neighboring gene STARR-seq mESC enhancer starr_30646 Neighboring gene STARR-seq mESC enhancer starr_30648 Neighboring gene predicted gene 11633 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:97839153-97839454 Neighboring gene STARR-positive B cell enhancer ABC_E7053 Neighboring gene STARR-positive B cell enhancer ABC_E3012 Neighboring gene STARR-positive B cell enhancer ABC_E5273 Neighboring gene STARR-positive B cell enhancer ABC_E10711 Neighboring gene nuclear encoded tRNA cysteine 55 (anticodon GCA) Neighboring gene nuclear encoded tRNA cysteine 54 (anticodon GCA) Neighboring gene ADP-ribosylation factor-like 5C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Modulation of tumor endothelial cell marker 7 expression during endothelial cell capillary morphogenesis. Wang XQ, et al. Microvasc Res, 2005 Nov. PMID 16202431
  2. A fusion-protein approach enabling mammalian cell production of tumor targeting protein domains for therapeutic development. Hu J, et al. Protein Sci, 2018 May. PMID 29500915, Free PMC Article
  3. Gene targeting using a promoterless gene trap vector ("targeted trapping") is an efficient method to mutate a large fraction of genes. Friedel RH, et al. Proc Natl Acad Sci U S A, 2005 Sep 13. PMID 16129827, Free PMC Article
  4. LDL receptor-related protein 1 regulates the abundance of diverse cell-signaling proteins in the plasma membrane proteome. Gaultier A, et al. J Proteome Res, 2010 Dec 3. PMID 20919742, Free PMC Article
  5. Identification of a binding partner for the endothelial cell surface proteins TEM7 and TEM7R. Nanda A, et al. Cancer Res, 2004 Dec 1. PMID 15574754

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A novel fusion expression system based on mouse TEM7 (tumor endothelial marker 7), which could facilitate protein expression.
    Title: A fusion-protein approach enabling mammalian cell production of tumor targeting protein domains for therapeutic development.
  2. Studies identify Plxdc1, Sema4D, and neuropilin-1 as novel LRP1-regulated cell-signaling proteins.
    Title: LDL receptor-related protein 1 regulates the abundance of diverse cell-signaling proteins in the plasma membrane proteome.
  3. TEM7 is a novel protein whose cell surface expression is essential during endothelial cell capillary morphogenesis
    Title: Modulation of tumor endothelial cell marker 7 expression during endothelial cell capillary morphogenesis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1)  1 citation
  • Endonuclease-mediated (5) 

General gene information

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Markers

Homology

Clone Names

  • MGC130377

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in bicellular tight junction IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 PubMed 
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
plexin domain-containing protein 1
Names
TEM7 related

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163608.1 → NP_001157080.1  plexin domain-containing protein 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001157080.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AI848450, AK036144, AL591209
    Consensus CDS
    CCDS48897.1
    UniProtKB/Swiss-Prot
    Q91ZV7
    Related
    ENSMUSP00000103191.3, ENSMUST00000107565.3
    Conserved Domains (3) summary
    pfam01437
    Location:311 → 355
    PSI; Plexin repeat
    pfam15756
    Location:367 → 455
    DUF4690; Domain of unknown function (DUF4690)
    cl02648
    Location:160 → 266
    NIDO; Nidogen-like

  2. NM_028199.3 → NP_082475.3  plexin domain-containing protein 1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_082475.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AI848450, AK153684, AL591209, BB129646
    Consensus CDS
    CCDS25333.1
    UniProtKB/Swiss-Prot
    A2A537, A2A538, Q29R73, Q8BM20, Q91ZV7, Q9CWV5
    UniProtKB/TrEMBL
    A0A172Q399
    Related
    ENSMUSP00000017561.9, ENSMUST00000017561.15
    Conserved Domains (3) summary
    pfam05283
    Location:304 → 441
    MGC-24; Multi-glycosylated core protein 24 (MGC-24), sialomucin
    pfam01437
    Location:304 → 348
    PSI; Plexin repeat
    cl02648
    Location:153 → 259
    NIDO; Nidogen-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    97814063..97879393 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157011.1 → XP_036012904.1  plexin domain-containing protein 1 isoform X2

    Conserved Domains (3) summary
    pfam05283
    Location:143 → 280
    MGC-24; Multi-glycosylated core protein 24 (MGC-24), sialomucin
    pfam01437
    Location:143 → 187
    PSI; Plexin repeat
    cl02648
    Location:4 → 98
    NIDO; Nidogen-like

  2. XM_006534301.5 → XP_006534364.1  plexin domain-containing protein 1 isoform X1

    Conserved Domains (1) summary
    cl02648
    Location:238 → 344
    NIDO; Nidogen-like
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91ZV7.2 GenPept UniProtKB/Swiss-Prot:Q91ZV7

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