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Kifbp kinesin family binding protein [ Mus musculus (house mouse) ]

Gene ID: 72320, updated on 5-Mar-2024

Summary

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Official Symbol
Kifbpprovided by MGI
Official Full Name
kinesin family binding proteinprovided by MGI
Primary source
MGI:MGI:1919570
See related
Ensembl:ENSMUSG00000036955 AllianceGenome:MGI:1919570
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
KBP; Kif1bp; mKIAA1279; 0710007C18Rik; 2510003E04Rik
Summary
Predicted to enable kinesin binding activity. Acts upstream of or within in utero embryonic development. Predicted to be located in mitochondrion. Is expressed in several structures, including brain; gut; and liver. Used to study Goldberg-Shprintzen syndrome. Human ortholog(s) of this gene implicated in Goldberg-Shprintzen syndrome. Orthologous to human KIFBP (kinesin family binding protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cortex adult (RPKM 29.4), cerebellum adult (RPKM 28.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 B4; 10 32.43 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (62394249..62414846, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (62558470..62579066, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene VPS26 retromer complex component A Neighboring gene STARR-seq mESC enhancer starr_26885 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:61949721-61949830 Neighboring gene STARR-seq mESC enhancer starr_26886 Neighboring gene STARR-positive B cell enhancer ABC_E6862 Neighboring gene STARR-positive B cell enhancer ABC_E6863 Neighboring gene STARR-positive B cell enhancer ABC_E6864 Neighboring gene serglycin Neighboring gene STARR-positive B cell enhancer ABC_E10614 Neighboring gene STARR-positive B cell enhancer ABC_E2327 Neighboring gene STARR-positive B cell enhancer ABC_E11441 Neighboring gene STARR-seq mESC enhancer starr_26888 Neighboring gene STARR-positive B cell enhancer ABC_E3889 Neighboring gene STARR-positive B cell enhancer ABC_E8339 Neighboring gene DExD box helicase 21 Neighboring gene STARR-positive B cell enhancer ABC_E10615 Neighboring gene STARR-seq mESC enhancer starr_26889 Neighboring gene DExD box helicase 50 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:62114124-62114233

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Multiple Functions of KBP in Neural Development Underlie Brain Anomalies in Goldberg-Shprintzen Syndrome. Chang HY, et al. Front Mol Neurosci, 2019. PMID 31736709, Free PMC Article
  2. KIF1-binding protein interacts with KIF3A in haploid male germ cells. Lehti MS, et al. Reproduction, 2015 Sep. PMID 26245936
  3. The TDH-GCN5L1-Fbxo15-KBP axis limits mitochondrial biogenesis in mouse embryonic stem cells. Donato V, et al. Nat Cell Biol, 2017 Apr. PMID 28319092, Free PMC Article
  4. The novel protein KBP regulates mitochondria localization by interaction with a kinesin-like protein. Wozniak MJ, et al. BMC Cell Biol, 2005 Oct 14. PMID 16225668, Free PMC Article
  5. KBP interacts with SCG10, linking Goldberg-Shprintzen syndrome to microtubule dynamics and neuronal differentiation. Alves MM, et al. Hum Mol Genet, 2010 Sep 15. PMID 20621975, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TDH, responsible for mitochondrial production of acetyl-CoA in mouse embryonic stem cells, and the acetyltransferase GCN5L1 cooperate to acetylate Lys501 in KBP, allowing its recognition by and degradation via Fbxo15, an F-box protein transcriptionally controlled by the pluripotency core factors and repressed following differentiation.
    Title: The TDH-GCN5L1-Fbxo15-KBP axis limits mitochondrial biogenesis in mouse embryonic stem cells.
  2. KIF1-binding protein interacts with KIF3A in haploid male germ cells, promoting spermatid elongation.
    Title: KIF1-binding protein interacts with KIF3A in haploid male germ cells.
  3. KBP expression is up-regulated during neuronal development in mouse cortical neurons.
    Title: KBP interacts with SCG10, linking Goldberg-Shprintzen syndrome to microtubule dynamics and neuronal differentiation.
  4. KBP is a new binding partner for KIF1Balpha that is a regulator of its transport function and thus represents a new type of kinesin interacting protein.
    Title: The novel protein KBP regulates mitochondria localization by interaction with a kinesin-like protein.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (2)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC107132

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables kinesin binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in central nervous system projection neuron axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in neuron projection maintenance IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
KIF-binding protein
Names
KIF1 binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028197.2 → NP_082473.2  KIF-binding protein

    See identical proteins and their annotated locations for NP_082473.2

    Status: VALIDATED

    Source sequence(s)
    BC038828, BC055307, BY729088
    Consensus CDS
    CCDS23890.1
    UniProtKB/Swiss-Prot
    Q3TYD0, Q5BKR5, Q6ZPU9, Q7TPE0, Q80VQ5, Q8BZE2, Q8CFS7
    Related
    ENSMUSP00000065160.8, ENSMUST00000065887.14
    Conserved Domains (1) summary
    pfam12309
    Location:243 → 609
    KBP_C; KIF-1 binding protein C terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    62394249..62414846 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514192.5 → XP_006514255.1  KIF-binding protein isoform X1

    UniProtKB/TrEMBL
    E0CXN7
    Related
    ENSMUSP00000134770.2, ENSMUST00000159704.8
    Conserved Domains (1) summary
    pfam12309
    Location:243 → 325
    KBP_C; KIF-1 binding protein C terminal
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZPU9.2 GenPept UniProtKB/Swiss-Prot:Q6ZPU9

Gene LinkOut

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