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LTO1 ABCE maturation factor [ Mus musculus (house mouse) ]

Gene ID: 72284, updated on 3-Apr-2024

Summary

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Official Symbol
LTO1provided by MGI
Official Full Name
ABCE maturation factorprovided by MGI
Primary source
MGI:MGI:1919534
See related
Ensembl:ENSMUSG00000031072 AllianceGenome:MGI:1919534
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TAOS1; Oraov1; 2210010N10Rik
Summary
Predicted to be involved in several processes, including protein maturation by [4Fe-4S] cluster transfer; telomere maintenance; and translational initiation. Predicted to be located in nucleus. Is expressed in cerebellum and rest of cerebellum mantle layer. Orthologous to human LTO1 (LTO1 maturation factor of ABCE1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 18.5), kidney adult (RPKM 17.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 F5; 7 88.92 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (144468882..144485989)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (144915100..144930748)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3764 Neighboring gene predicted gene, 39119 Neighboring gene STARR-positive B cell enhancer mm9_chr7:152123400-152123700 Neighboring gene brain cytoplasmic RNA 1 Neighboring gene cyclin D1 Neighboring gene STARR-seq mESC enhancer starr_20559 Neighboring gene STARR-seq mESC enhancer starr_20560 Neighboring gene predicted gene, 46023 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:152297325-152297512 Neighboring gene STARR-seq mESC enhancer starr_20563 Neighboring gene predicted gene 45181

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Neural BC1 RNA: cDNA clones reveal nonrepetitive sequence content. DeChiara TM, et al. Proc Natl Acad Sci U S A, 1987 May. PMID 2437583, Free PMC Article
  2. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  3. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in protein maturation by [4Fe-4S] cluster transfer ISO
Inferred from Sequence Orthology
more info
  
involved_in ribosomal large subunit biogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in telomere maintenance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translational initiation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein LTO1 homolog
Names
oral cancer overexpressed 1
oral cancer-overexpressed protein 1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347536.2 → NP_001334465.2  protein LTO1 homolog isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC161763
    Consensus CDS
    CCDS85485.1
    UniProtKB/TrEMBL
    D3Z5L0
    Related
    ENSMUSP00000101515.3, ENSMUST00000105895.2

  2. NM_001347537.2 → NP_001334466.2  protein LTO1 homolog isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC161763
    Consensus CDS
    CCDS85486.1
    UniProtKB/TrEMBL
    F6SHW1
    Related
    ENSMUSP00000115840.3, ENSMUST00000128057.8

  3. NM_001357868.2 → NP_001344797.2  protein LTO1 homolog isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC161763

  4. NM_001357869.2 → NP_001344798.2  protein LTO1 homolog isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC161763

  5. NM_001361263.2 → NP_001348192.2  protein LTO1 homolog isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC161763

  6. NM_028184.5 → NP_082460.3  protein LTO1 homolog isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC161763
    Consensus CDS
    CCDS22054.1
    UniProtKB/Swiss-Prot
    Q8CH62, Q91YY7, Q922P0, Q9D7Y4
    Related
    ENSMUSP00000033388.7, ENSMUST00000033388.13

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    144468882..144485989
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CH62.1 GenPept UniProtKB/Swiss-Prot:Q8CH62

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