U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ccpg1 cell cycle progression 1 [ Mus musculus (house mouse) ]

Gene ID: 72278, updated on 21-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Ccpg1provided by MGI
Official Full Name
cell cycle progression 1provided by MGI
Primary source
MGI:MGI:1196419
See related
Ensembl:ENSMUSG00000034563 AllianceGenome:MGI:1196419
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CPR8; D9Ertd392e; 1700030B06Rik; 1810073J13Rik; 9430028F23Rik
Summary
Acts upstream of or within positive regulation of transcription by RNA polymerase II and regulation of Rho guanyl-nucleotide exchange factor activity. Located in membrane. Is expressed in cranial ganglion; dorsal root ganglion; sensory organ; and skeleton. Orthologous to human CCPG1 (cell cycle progression 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 12.0), frontal lobe adult (RPKM 11.9) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
9 D; 9 40.08 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (72892692..72923622)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (72985402..73016340)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene dynein axonemal assembly factor 4 Neighboring gene predicted gene, 23567 Neighboring gene STARR-positive B cell enhancer ABC_E3843 Neighboring gene piercer of microtubule wall 2 Neighboring gene STARR-seq mESC enhancer starr_24620 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class B Neighboring gene Pigb opposite strand 1 Neighboring gene RAB27A, member RAS oncogene family Neighboring gene STARR-seq mESC enhancer starr_24625 Neighboring gene STARR-seq mESC enhancer starr_24627

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. CCPG1 Is a Non-canonical Autophagy Cargo Receptor Essential for ER-Phagy and Pancreatic ER Proteostasis. Smith MD, et al. Dev Cell, 2018 Jan 22. PMID 29290589, Free PMC Article
  2. A biphasic pattern of gene expression during mouse retina development. Zhang SS, et al. BMC Dev Biol, 2006 Oct 17. PMID 17044933, Free PMC Article
  3. Ccpg1, a novel scaffold protein that regulates the activity of the Rho guanine nucleotide exchange factor Dbs. Kostenko EV, et al. Mol Cell Biol, 2006 Dec. PMID 17000758, Free PMC Article
  4. TRIM27 cooperates with STK38L to inhibit ULK1-mediated autophagy and promote tumorigenesis. Yang Y, et al. EMBO J, 2022 Jul 18. PMID 35670107, Free PMC Article
  5. Transcriptome analysis of mouse stem cells and early embryos. Sharov AA, et al. PLoS Biol, 2003 Dec. PMID 14691545, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (4) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of Rho guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of Rho guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
cell cycle progression protein 1
Names
cell cycle progression 8 protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001114328.2 → NP_001107800.1  cell cycle progression protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001107800.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) lacks an alternate exon in the 5' coding region and includes a 3' terminal exon that extends past a splice site that is used in variant 6. It encodes isoform 1, which has a distinct C-terminus and is shorter, compared to isoform 6.
    Source sequence(s)
    AK032645, BC082602, CN721780
    Consensus CDS
    CCDS52855.1
    UniProtKB/Swiss-Prot
    Q05BJ9, Q640L3, Q8C692, Q922W9
    Related
    ENSMUSP00000122966.2, ENSMUST00000150826.9
    Conserved Domains (1) summary
    pfam10577
    Location:133 → 218
    UPF0560; uncharacterized protein family UPF0560

  2. NM_001286544.1 → NP_001273473.1  cell cycle progression protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001273473.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon in the 5' coding region, compared to variant 6. It encodes a shorter isoform (3), compared to isoform 6.
    Source sequence(s)
    BC043049, CN721780
    Consensus CDS
    CCDS72278.1
    UniProtKB/Swiss-Prot
    Q640L3
    Related
    ENSMUSP00000082458.5, ENSMUST00000085350.11
    Conserved Domains (1) summary
    pfam10577
    Location:133 → 218
    UPF0560; uncharacterized protein family UPF0560

  3. NM_001286545.1 → NP_001273474.1  cell cycle progression protein 1 isoform 4

    See identical proteins and their annotated locations for NP_001273474.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate exon in the 5' coding region and uses an alternate 3' structure, compared to variant 6. It encodes isoform 4, which has a distinct C-terminus and is shorter, compared to isoform 6.
    Source sequence(s)
    AC158997, AK134675, BC037183, BC043049, CN721780
    Consensus CDS
    CCDS72277.1
    UniProtKB/TrEMBL
    D3Z7R9
    Related
    ENSMUSP00000116976.2, ENSMUST00000140675.8
    Conserved Domains (1) summary
    pfam10577
    Location:133 → 218
    UPF0560; uncharacterized protein family UPF0560

  4. NM_001286546.1 → NP_001273475.1  cell cycle progression protein 1 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate exon in the 5' coding region, uses an alternate internal splice site and includes a 3' terminal exon that extends past a splice site that is used in variant 6. It encodes isoform 5, which has a distinct C-terminus and is shorter, compared to isoform 6.
    Source sequence(s)
    AK032645, BC082602, CN721780
    UniProtKB/Swiss-Prot
    Q640L3
    Conserved Domains (2) summary
    COG1196
    Location:186 → 445
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15662
    Location:32 → 116
    SPATA3; Spermatogenesis-associated protein 3 family

  5. NM_001359295.1 → NP_001346224.1  cell cycle progression protein 1 isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) represents the longest transcript and encodes the longest isoform (6).
    Source sequence(s)
    AC158997, BC043049
    Conserved Domains (2) summary
    COG1196
    Location:318 → 577
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam07267
    Location:90 → 242
    Nucleo_P87; Nucleopolyhedrovirus capsid protein P87

  6. NM_001359296.1 → NP_001346225.1  cell cycle progression protein 1 isoform 7

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 6. It encodes isoform 7, which has a distinct C-terminus and is shorter, compared to isoform 6.
    Source sequence(s)
    AC158997, BC043049
    Conserved Domains (2) summary
    pfam07267
    Location:130 → 242
    Nucleo_P87; Nucleopolyhedrovirus capsid protein P87
    cl25732
    Location:318 → 577
    SMC_N; RecF/RecN/SMC N terminal domain

  7. NM_028181.5 → NP_082457.3  cell cycle progression protein 1 isoform 2

    See identical proteins and their annotated locations for NP_082457.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' coding region and uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 6. It encodes isoform 2, which has a distinct C-terminus and is shorter, compared to isoform 6.
    Source sequence(s)
    AK076325, AK134675, BC043049, CN721780
    Consensus CDS
    CCDS23334.1
    UniProtKB/Swiss-Prot
    Q640L3
    Related
    ENSMUSP00000045669.8, ENSMUST00000037977.15
    Conserved Domains (1) summary
    pfam10577
    Location:133 → 218
    UPF0560; uncharacterized protein family UPF0560

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    72892692..72923622
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155316.1 → XP_036011209.1  cell cycle progression protein 1 isoform X2

    Conserved Domains (2) summary
    COG1196
    Location:327 → 586
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam07267
    Location:90 → 242
    Nucleo_P87; Nucleopolyhedrovirus capsid protein P87

  2. XM_036155318.1 → XP_036011211.1  cell cycle progression protein 1 isoform X5

    Conserved Domains (2) summary
    PLN02328
    Location:110 → 264
    PLN02328; lysine-specific histone demethylase 1 homolog
    COG1196
    Location:327 → 586
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  3. XM_006511469.5 → XP_006511532.1  cell cycle progression protein 1 isoform X4

    Conserved Domains (2) summary
    COG1196
    Location:318 → 577
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam07267
    Location:90 → 242
    Nucleo_P87; Nucleopolyhedrovirus capsid protein P87

  4. XM_036155314.1 → XP_036011207.1  cell cycle progression protein 1 isoform X1

    Conserved Domains (2) summary
    COG1196
    Location:327 → 586
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam07267
    Location:90 → 242
    Nucleo_P87; Nucleopolyhedrovirus capsid protein P87

  5. XM_036155317.1 → XP_036011210.1  cell cycle progression protein 1 isoform X3

    Conserved Domains (2) summary
    PLN02328
    Location:86 → 232
    PLN02328; lysine-specific histone demethylase 1 homolog
    COG1196
    Location:295 → 554
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  6. XM_036155315.1 → XP_036011208.1  cell cycle progression protein 1 isoform X1

    Conserved Domains (2) summary
    COG1196
    Location:327 → 586
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam07267
    Location:90 → 242
    Nucleo_P87; Nucleopolyhedrovirus capsid protein P87

RNA

  1. XR_004935565.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q640L3.2 GenPept UniProtKB/Swiss-Prot:Q640L3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous