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Eml2 echinoderm microtubule associated protein like 2 [ Mus musculus (house mouse) ]

Gene ID: 72205, updated on 11-Apr-2024

Summary

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Official Symbol
Eml2provided by MGI
Official Full Name
echinoderm microtubule associated protein like 2provided by MGI
Primary source
MGI:MGI:1919455
See related
Ensembl:ENSMUSG00000040811 AllianceGenome:MGI:1919455
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EMAP-2; 1600029N02Rik
Summary
Predicted to enable microtubule binding activity; protein C-terminus binding activity; and signaling receptor binding activity. Predicted to be involved in microtubule cytoskeleton organization; negative regulation of microtubule polymerization; and regulation of microtubule nucleation. Predicted to be located in cytoplasm and microtubule. Predicted to colocalize with mitotic spindle. Is expressed in genitourinary system; gut gland; heart; nervous system; and retina. Orthologous to human EML2 (EMAP like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 25.4), cortex adult (RPKM 23.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 A3; 7 9.46 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (18910322..18940407)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (19176421..19206482)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1081 Neighboring gene small nuclear ribonucleoprotein D2 Neighboring gene gastric inhibitory polypeptide receptor Neighboring gene microRNA 330 Neighboring gene VISTA enhancer mm1753 Neighboring gene G protein-coupled receptor 4 Neighboring gene optic atrophy 3 Neighboring gene STARR-positive B cell enhancer ABC_E3702 Neighboring gene predicted gene, 25134

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. MS/MS in silico subtraction-based proteomic profiling as an approach to facilitate disease gene discovery: application to lens development and cataract. Aryal S, et al. Hum Genet, 2020 Feb. PMID 31797049, Free PMC Article
  2. Efficient capture of cardiogenesis-associated genes expressed in ES cells. Terami H, et al. Biochem Biophys Res Commun, 2007 Mar 30. PMID 17286962
  3. Mutations in Spliceosomal Genes PPIL1 and PRP17 Cause Neurodegenerative Pontocerebellar Hypoplasia with Microcephaly. Chai G, et al. Neuron, 2021 Jan 20. PMID 33220177, Free PMC Article
  4. Spatiotemporal gene expression patterns reveal molecular relatedness between retinal laminae. Jiang D, et al. J Comp Neurol, 2020 Apr 1. PMID 31609468, Free PMC Article
  5. Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells. Latos PA, et al. Nat Commun, 2015 Jul 24. PMID 26206133, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ionotropic glutamate receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
  
enables tubulin binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of microtubule polymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of microtubule nucleation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
colocalizes_with mitotic spindle IBA
Inferred from Biological aspect of Ancestor
more info
  
colocalizes_with mitotic spindle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
echinoderm microtubule-associated protein-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001162996.2 → NP_001156468.1  echinoderm microtubule-associated protein-like 2 isoform 2

    See identical proteins and their annotated locations for NP_001156468.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding region, compared to variant 3. These differences cause translation initiation at a novel AUG and result in an isoform (2) with a shorter and distinct N-terminus, compared to isoform 3.
    Source sequence(s)
    AC145199
    Consensus CDS
    CCDS85224.1
    UniProtKB/Swiss-Prot
    E9QK48, Q7TNG5, Q9DAS8
    Related
    ENSMUSP00000112447.3, ENSMUST00000120595.8
    Conserved Domains (4) summary
    COG2319
    Location:76 → 497
    WD40; WD40 repeat [General function prediction only]
    pfam03451
    Location:19 → 91
    HELP; HELP motif
    sd00039
    Location:297 → 335
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:348 → 647
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. NM_001347582.2 → NP_001334511.1  echinoderm microtubule-associated protein-like 2 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) encodes the longest isoform (3).
    Source sequence(s)
    AC145199
    Consensus CDS
    CCDS85223.1
    UniProtKB/TrEMBL
    E9QK48
    Related
    ENSMUSP00000112491.2, ENSMUST00000117338.8

  3. NM_028153.2 → NP_082429.1  echinoderm microtubule-associated protein-like 2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR and coding region, compared to variant 3. These differences cause translation initiation at a novel AUG and result in an isoform (1) with a shorter and distinct N-terminus, compared to isoform 3.
    Source sequence(s)
    AC145199
    Consensus CDS
    CCDS52055.1
    UniProtKB/Swiss-Prot
    Q7TNG5
    Related
    ENSMUSP00000037654.9, ENSMUST00000048502.10
    Conserved Domains (4) summary
    COG2319
    Location:95 → 516
    WD40; WD40 repeat [General function prediction only]
    pfam03451
    Location:19 → 110
    HELP; HELP motif
    sd00039
    Location:316 → 354
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:367 → 666
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    18910322..18940407
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011250714.3 → XP_011249016.1  echinoderm microtubule-associated protein-like 2 isoform X1

    Conserved Domains (4) summary
    COG2319
    Location:267 → 688
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:401 → 438
    7WD40; WD40 repeat [structural motif]
    pfam03451
    Location:210 → 282
    HELP; HELP motif
    cl29593
    Location:695 → 840
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. XM_011250715.2 → XP_011249017.1  echinoderm microtubule-associated protein-like 2 isoform X2

    Conserved Domains (5) summary
    COG2319
    Location:222 → 643
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:356 → 393
    7WD40; WD40 repeat [structural motif]
    pfam03451
    Location:165 → 237
    HELP; HELP motif
    cl01090
    Location:14 → 69
    SlyX
    cl29593
    Location:650 → 795
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  3. XM_030243010.1 → XP_030098870.1  echinoderm microtubule-associated protein-like 2 isoform X4

    Conserved Domains (3) summary
    COG2319
    Location:22 → 381
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:181 → 219
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:302 → 532
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  4. XM_011250719.2 → XP_011249021.1  echinoderm microtubule-associated protein-like 2 isoform X3

    See identical proteins and their annotated locations for XP_011249021.1

    Conserved Domains (4) summary
    COG2319
    Location:61 → 482
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:282 → 320
    7WD40; WD40 repeat [structural motif]
    pfam03451
    Location:4 → 76
    HELP; HELP motif
    cl29593
    Location:489 → 634
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  5. XM_011250718.3 → XP_011249020.1  echinoderm microtubule-associated protein-like 2 isoform X3

    See identical proteins and their annotated locations for XP_011249020.1

    Conserved Domains (4) summary
    COG2319
    Location:61 → 482
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:282 → 320
    7WD40; WD40 repeat [structural motif]
    pfam03451
    Location:4 → 76
    HELP; HELP motif
    cl29593
    Location:489 → 634
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RNA

  1. XR_001778001.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TNG5.1 GenPept UniProtKB/Swiss-Prot:Q7TNG5

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