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Otud6b OTU domain containing 6B [ Mus musculus (house mouse) ]

Gene ID: 72201, updated on 3-Apr-2024

Summary

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Official Symbol
Otud6bprovided by MGI
Official Full Name
OTU domain containing 6Bprovided by MGI
Primary source
MGI:MGI:1919451
See related
Ensembl:ENSMUSG00000040550 AllianceGenome:MGI:1919451
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2600013N14Rik
Summary
Predicted to enable thiol-dependent deubiquitinase. Predicted to be involved in several processes, including proteasome assembly; protein deubiquitination; and regulation of translation. Predicted to be part of eukaryotic translation initiation factor 4F complex. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and liver and biliary system. Orthologous to human OTUD6B (OTU deubiquitinase 6B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 13.1), CNS E11.5 (RPKM 11.8) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Otud6b in Genome Data Viewer
Location:
4 A1; 4 6.38 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (14809503..14826413, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (14809505..14826413, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_09634 Neighboring gene STARR-seq mESC enhancer starr_09635 Neighboring gene solute carrier family 26, member 7 Neighboring gene STARR-seq mESC enhancer starr_09636 Neighboring gene leucine rich repeat containing 69 Neighboring gene STARR-seq mESC enhancer starr_09637 Neighboring gene STARR-positive B cell enhancer ABC_E6153 Neighboring gene phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2 Neighboring gene predicted gene 11837 Neighboring gene N-terminal EF-hand calcium binding protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Biallelic Variants in OTUD6B Cause an Intellectual Disability Syndrome Associated with Seizures and Dysmorphic Features. Santiago-Sim T, et al. Am J Hum Genet, 2017 Apr 6. PMID 28343629, Free PMC Article
  2. Evidence for OTUD-6B participation in B lymphocytes cell cycle after cytokine stimulation. Xu Z, et al. PLoS One, 2011 Jan 18. PMID 21267069, Free PMC Article
  3. Transcriptome analysis of mouse stem cells and early embryos. Sharov AA, et al. PLoS Biol, 2003 Dec. PMID 14691545, Free PMC Article
  4. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
  5. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC103361

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of translation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of translation ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasome assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in protein deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein deubiquitination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of eukaryotic translation initiation factor 4F complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
deubiquitinase OTUD6B
Names
OTU domain-containing protein 6B
ortholog of human CGI-77
NP_001402950.1
NP_690025.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001416021.1 → NP_001402950.1  deubiquitinase OTUD6B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL831792

  2. NM_152812.5 → NP_690025.3  deubiquitinase OTUD6B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL831792
    Consensus CDS
    CCDS17980.3
    UniProtKB/Swiss-Prot
    A2AP24, Q3T9X5, Q3U1R9, Q8K2H2
    UniProtKB/TrEMBL
    A0A0A0MQF5
    Related
    ENSMUSP00000113553.3, ENSMUST00000117268.9
    Conserved Domains (2) summary
    COG5539
    Location:3 → 281
    COG5539; Predicted cysteine protease (OTU family) [Posttranslational modification, protein turnover, chaperones]
    pfam02338
    Location:154 → 279
    OTU; OTU-like cysteine protease

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    14809503..14826413 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K2H2.1 GenPept UniProtKB/Swiss-Prot:Q8K2H2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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