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Supt7l SPT7-like, STAGA complex gamma subunit [ Mus musculus (house mouse) ]

Gene ID: 72195, updated on 5-Mar-2024

Summary

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Official Symbol
Supt7lprovided by MGI
Official Full Name
SPT7-like, STAGA complex gamma subunitprovided by MGI
Primary source
MGI:MGI:1919445
See related
Ensembl:ENSMUSG00000053134 AllianceGenome:MGI:1919445
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2610524B01Rik; 6030455L14Rik
Summary
Predicted to enable transcription coactivator activity. Predicted to be involved in histone H3 acetylation and maintenance of protein location in nucleus. Predicted to be located in nucleoplasm. Predicted to be part of SAGA complex. Is expressed in brain; cerebral cortex; hippocampus; and main olfactory bulb. Orthologous to human SUPT7L (SPT7 like, STAGA complex subunit gamma). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in subcutaneous fat pad adult (RPKM 6.3), kidney adult (RPKM 6.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 B1; 5 17.27 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (31671913..31684106, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (31514569..31526762, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_12771 Neighboring gene coiled-coil domain containing 121 Neighboring gene STARR-positive B cell enhancer ABC_E6315 Neighboring gene STARR-seq mESC enhancer starr_12772 Neighboring gene GPN-loop GTPase 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:31829068-31829342 Neighboring gene solute carrier family 4 (anion exchanger), member 1, adaptor protein Neighboring gene STARR-seq mESC enhancer starr_12773 Neighboring gene expressed sequence AI839979

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The human SPT20-containing SAGA complex plays a direct role in the regulation of endoplasmic reticulum stress-induced genes. Nagy Z, et al. Mol Cell Biol, 2009 Mar. PMID 19114550, Free PMC Article
  2. Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo. Martinez E, et al. Mol Cell Biol, 2001 Oct. PMID 11564863, Free PMC Article
  3. A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing. Zhao Y, et al. Mol Cell, 2008 Jan 18. PMID 18206972
  4. A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. McKee AE, et al. BMC Dev Biol, 2005 Jul 20. PMID 16033648, Free PMC Article
  5. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in maintenance of protein location in nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of DNA repair NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of RNA splicing NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of SAGA complex ISO
Inferred from Sequence Orthology
more info
  
part_of SAGA complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
STAGA complex 65 subunit gamma
Names
SPTF-associated factor 65 gamma
STAF65gamma
suppressor of Ty 7-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028150.2 → NP_082426.1  STAGA complex 65 subunit gamma

    See identical proteins and their annotated locations for NP_082426.1

    Status: VALIDATED

    Source sequence(s)
    BC031447, BY129485
    Consensus CDS
    CCDS19186.1
    UniProtKB/Swiss-Prot
    Q9CZV5
    UniProtKB/TrEMBL
    Q3UMC6
    Related
    ENSMUSP00000067337.5, ENSMUST00000065388.11
    Conserved Domains (1) summary
    cl22885
    Location:149 → 224
    TAF9; TATA Binding Protein (TBP) Associated Factor 9 (TAF9) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    31671913..31684106 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CZV5.1 GenPept UniProtKB/Swiss-Prot:Q9CZV5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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