U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Fbxl20 F-box and leucine-rich repeat protein 20 [ Mus musculus (house mouse) ]

Gene ID: 72194, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Fbxl20provided by MGI
Official Full Name
F-box and leucine-rich repeat protein 20provided by MGI
Primary source
MGI:MGI:1919444
See related
Ensembl:ENSMUSG00000020883 AllianceGenome:MGI:1919444
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Scr; Fbl2; mKIAA4147; 2610511F20Rik; 4632423N09Rik
Summary
Involved in regulation of protein catabolic process at presynapse, modulating synaptic transmission and regulation of synaptic vesicle exocytosis. Acts upstream of or within behavioral fear response. Located in Schaffer collateral - CA1 synapse. Is active in glutamatergic synapse. Is expressed in several structures, including adrenal gland; brain; genitourinary system; gut; and respiratory system. Orthologous to human FBXL20 (F-box and leucine rich repeat protein 20). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 14.8), thymus adult (RPKM 11.5) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
11 D; 11 61.69 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (97973380..98042014, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (98082554..98150921, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene calcium channel, voltage-dependent, beta 1 subunit Neighboring gene STARR-positive B cell enhancer ABC_E3013 Neighboring gene ribosomal protein L19 Neighboring gene STARR-positive B cell enhancer ABC_E9372 Neighboring gene STARR-seq mESC enhancer starr_30655 Neighboring gene SH3 and cysteine rich domain 2 Neighboring gene STARR-seq mESC enhancer starr_30656 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:97944979-97945162 Neighboring gene mediator complex subunit 1 Neighboring gene STARR-positive B cell enhancer ABC_E10712 Neighboring gene STARR-positive B cell enhancer mm9_chr11:98063825-98064126 Neighboring gene ribosomal protein S6 pseudogene Neighboring gene predicted gene, 38963 Neighboring gene cyclin dependent kinase 12

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Region-specific effects of Scrapper on the abundance of glutamate and gamma-aminobutyric acid in the mouse brain. Eto F, et al. Sci Rep, 2020 May 4. PMID 32366828, Free PMC Article
  2. SCRAPPER Selectively Contributes to Spontaneous Release and Presynaptic Long-Term Potentiation in the Anterior Cingulate Cortex. Koga K, et al. J Neurosci, 2017 Apr 5. PMID 28292828, Free PMC Article
  3. SCRAPPER regulates the thresholds of long-term potentiation/depression, the bidirectional synaptic plasticity in hippocampal CA3-CA1 synapses. Takagi H, et al. Neural Plast, 2012. PMID 23316391, Free PMC Article
  4. Synaptic E3 ligase SCRAPPER in contextual fear conditioning: extensive behavioral phenotyping of Scrapper heterozygote and overexpressing mutant mice. Yao I, et al. PLoS One, 2011 Feb 24. PMID 21390313, Free PMC Article
  5. SCRAPPER-dependent ubiquitination of active zone protein RIM1 regulates synaptic vesicle release. Yao I, et al. Cell, 2007 Sep 7. PMID 17803915, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Region-specific effects of Scrapper on the abundance of glutamate and gamma-aminobutyric acid in the mouse brain.
    Title: Region-specific effects of Scrapper on the abundance of glutamate and gamma-aminobutyric acid in the mouse brain.
  2. SCRAPPER plays a critical role in the anterior cingulate cortex pre-long term potentiation as well as synaptic transmission.
    Title: SCRAPPER Selectively Contributes to Spontaneous Release and Presynaptic Long-Term Potentiation in the Anterior Cingulate Cortex.
  3. SCRAPPER regulates the threshold of bidirectional synaptic plasticity and, therefore, metaplasticity.
    Title: SCRAPPER regulates the thresholds of long-term potentiation/depression, the bidirectional synaptic plasticity in hippocampal CA3-CA1 synapses.
  4. The behavioral phenotypes of Scrapper mutant mice suggest that molecular degradation conferred by SCRAPPER play important roles in hippocampal-dependent fear memory formation.
    Title: Synaptic E3 ligase SCRAPPER in contextual fear conditioning: extensive behavioral phenotyping of Scrapper heterozygote and overexpressing mutant mice.
  5. SCRAPPER is synapse localized E3 ubiquitin ligase which binds/ubiquinates RIM1 to regulate synaptic transmission.
    Title: SCRAPPER-dependent ubiquitination of active zone protein RIM1 regulates synaptic vesicle release.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • KIAA4147

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within behavioral fear response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of protein catabolic process at presynapse, modulating synaptic transmission IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of protein catabolic process at presynapse, modulating synaptic transmission IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in regulation of protein catabolic process at presynapse, modulating synaptic transmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of synaptic vesicle exocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of synaptic vesicle exocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in Schaffer collateral - CA1 synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in Schaffer collateral - CA1 synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IEP
Inferred from Expression Pattern
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in presynapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in synapse IEP
Inferred from Expression Pattern
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
F-box/LRR-repeat protein 20
Names
scrapper

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028149.1 → NP_082425.1  F-box/LRR-repeat protein 20

    See identical proteins and their annotated locations for NP_082425.1

    Status: VALIDATED

    Source sequence(s)
    AK028535, AK144786, AL591209, BB656518, CX211402
    Consensus CDS
    CCDS25339.1
    UniProtKB/Swiss-Prot
    A7YE80, Q3UMN2, Q571F7, Q8BZ95, Q9CZV8
    Related
    ENSMUSP00000099432.4, ENSMUST00000103143.10
    Conserved Domains (3) summary
    cd09293
    Location:220 → 394
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:119 → 144
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:28 → 69
    F-box-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    97973380..98042014 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534299.5 → XP_006534362.1  F-box/LRR-repeat protein 20 isoform X2

    UniProtKB/Swiss-Prot
    Q9CZV8
    Conserved Domains (3) summary
    cd09293
    Location:206 → 380
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:105 → 130
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:14 → 55
    F-box-like

  2. XM_030246362.2 → XP_030102222.1  F-box/LRR-repeat protein 20 isoform X3

    Conserved Domains (2) summary
    cd09293
    Location:62 → 236
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:13 → 38
    LRR_AMN1; leucine-rich repeat [structural motif]

  3. XM_006534298.4 → XP_006534361.1  F-box/LRR-repeat protein 20 isoform X1

    See identical proteins and their annotated locations for XP_006534361.1

    UniProtKB/Swiss-Prot
    Q9CZV8
    Conserved Domains (3) summary
    cd09293
    Location:222 → 396
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:121 → 146
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:30 → 71
    F-box-like

  4. XM_036157010.1 → XP_036012903.1  F-box/LRR-repeat protein 20 isoform X3

    Conserved Domains (2) summary
    cd09293
    Location:62 → 236
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:13 → 38
    LRR_AMN1; leucine-rich repeat [structural motif]

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_134030.1: Suppressed sequence

    Description
    NM_134030.1: This RefSeq was permanently suppressed because it is primarily UTR sequence.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CZV8.3 GenPept UniProtKB/Swiss-Prot:Q9CZV8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous