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Fbxl2 F-box and leucine-rich repeat protein 2 [ Mus musculus (house mouse) ]

Gene ID: 72179, updated on 11-Apr-2024

Summary

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Official Symbol
Fbxl2provided by MGI
Official Full Name
F-box and leucine-rich repeat protein 2provided by MGI
Primary source
MGI:MGI:1919429
See related
Ensembl:ENSMUSG00000032507 AllianceGenome:MGI:1919429
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fbl3; 2810423A21Rik
Summary
Predicted to enable phosphatidylinositol 3-kinase regulatory subunit binding activity and protein phosphatase binding activity. Acts upstream of or within protein monoubiquitination and ubiquitin-dependent protein catabolic process. Predicted to be located in membrane. Predicted to be part of SCF ubiquitin ligase complex. Is expressed in dorsal root ganglion; glossopharyngeal ganglion; and trigeminal ganglion. Orthologous to human FBXL2 (F-box and leucine rich repeat protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cortex adult (RPKM 11.6), CNS E18 (RPKM 10.1) and 24 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 F3; 9 64.17 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (113787625..113855871, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (113958557..114026803, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene CLIP associating protein 2 Neighboring gene predicted gene, 25059 Neighboring gene STARR-positive B cell enhancer ABC_E2309 Neighboring gene predicted gene, 39439 Neighboring gene upstream binding protein 1 Neighboring gene predicted gene, 36035 Neighboring gene STARR-seq mESC enhancer starr_25334 Neighboring gene predicted gene, 36883 Neighboring gene sushi domain containing 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cross-Regulation of F-Box Protein FBXL2 with T-bet and TNF-α during Acute and Chronic Lung Allograft Rejection. Das A, et al. J Immunol, 2022 Nov 1. PMID 36113884, Free PMC Article
  2. Low-intensity pulsed ultrasound (LIPUS) prevents periprosthetic inflammatory loosening through FBXL2-TRAF6 ubiquitination pathway. Zhao X, et al. Sci Rep, 2017 Apr 5. PMID 28378753, Free PMC Article
  3. A combinatorial F box protein directed pathway controls TRAF adaptor stability to regulate inflammation. Chen BB, et al. Nat Immunol, 2013 May. PMID 23542741, Free PMC Article
  4. F-box protein FBXL2 exerts human lung tumor suppressor-like activity by ubiquitin-mediated degradation of cyclin D3 resulting in cell cycle arrest. Chen BB, et al. Oncogene, 2012 May 17. PMID 22020328, Free PMC Article
  5. Skp-cullin-F box E3 ligase component FBXL2 ubiquitinates Aurora B to inhibit tumorigenesis. Chen BB, et al. Cell Death Dis, 2013 Aug 8. PMID 23928698, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cross-Regulation of F-Box Protein FBXL2 with T-bet and TNF-alpha during Acute and Chronic Lung Allograft Rejection.
    Title: Cross-Regulation of F-Box Protein FBXL2 with T-bet and TNF-α during Acute and Chronic Lung Allograft Rejection.
  2. Study demonstrated that TRAF6 plays an important role in the process of aseptic inflammatory loosening caused by periprosthetic debris, and Low intensity pulsed ultrasound was found to inhibit such inflammation through increasing the level of FBXL2, and further increasing ubiquitination of TRAF6.
    Title: Low-intensity pulsed ultrasound (LIPUS) prevents periprosthetic inflammatory loosening through FBXL2-TRAF6 ubiquitination pathway.
  3. FBXL2 mediates Aurora B ubiquitination and degradation within the midbody, which is sufficient to induce mitotic arrest and apoptosis.
    Title: Skp-cullin-F box E3 ligase component FBXL2 ubiquitinates Aurora B to inhibit tumorigenesis.
  4. FBXL2 is a ubiquitin E3 ligase subunit that triggers mitotic arrest.
    Title: FBXL2 is a ubiquitin E3 ligase subunit that triggers mitotic arrest.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol 3-kinase regulatory subunit binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-like ligase-substrate adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin-like ligase-substrate adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in modulation by host of viral RNA genome replication ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of NLRP3 inflammasome complex assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein monoubiquitination IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within protein monoubiquitination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of autophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of inflammatory response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SCF ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
F-box/LRR-repeat protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178624.7 → NP_848739.1  F-box/LRR-repeat protein 2

    See identical proteins and their annotated locations for NP_848739.1

    Status: VALIDATED

    Source sequence(s)
    CT025531
    Consensus CDS
    CCDS40790.1
    UniProtKB/Swiss-Prot
    Q8BH16, Q8BXM4
    UniProtKB/TrEMBL
    Q3TQM5, Q4VA21
    Related
    ENSMUSP00000035090.8, ENSMUST00000035090.14
    Conserved Domains (3) summary
    cd09293
    Location:168 → 367
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:106 → 131
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:15 → 57
    F-box-like; F-box-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    113787625..113855871 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030244622.1 → XP_030100482.1  F-box/LRR-repeat protein 2 isoform X3

    Conserved Domains (2) summary
    cd09293
    Location:63 → 262
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:27 → 52
    LRR_AMN1; leucine-rich repeat [structural motif]

  2. XM_030244623.2 → XP_030100483.1  F-box/LRR-repeat protein 2 isoform X3

    Conserved Domains (2) summary
    cd09293
    Location:63 → 262
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:27 → 52
    LRR_AMN1; leucine-rich repeat [structural motif]

  3. XM_011243027.3 → XP_011241329.1  F-box/LRR-repeat protein 2 isoform X3

    See identical proteins and their annotated locations for XP_011241329.1

    Conserved Domains (2) summary
    cd09293
    Location:63 → 262
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:27 → 52
    LRR_AMN1; leucine-rich repeat [structural motif]

  4. XM_036155307.1 → XP_036011200.1  F-box/LRR-repeat protein 2 isoform X2

    Conserved Domains (3) summary
    cd09293
    Location:80 → 275
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:106 → 131
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:15 → 56
    F-box-like

  5. XM_036155306.1 → XP_036011199.1  F-box/LRR-repeat protein 2 isoform X1

    Conserved Domains (3) summary
    cd09293
    Location:80 → 275
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:52 → 79
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:15 → 56
    F-box-like

  6. XM_006512295.3 → XP_006512358.1  F-box/LRR-repeat protein 2 isoform X4

    Conserved Domains (3) summary
    cd09293
    Location:80 → 275
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:52 → 79
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:15 → 56
    F-box-like

RNA

  1. XR_379878.4 RNA Sequence

  2. XR_003948012.2 RNA Sequence

  3. XR_379879.3 RNA Sequence

  4. XR_379880.5 RNA Sequence

  5. XR_004935563.1 RNA Sequence

    Related
    ENSMUST00000143180.8

  6. XR_003948011.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BH16.1 GenPept UniProtKB/Swiss-Prot:Q8BH16

Gene LinkOut

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