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Shq1 SHQ1 homolog (S. cerevisiae) [ Mus musculus (house mouse) ]

Gene ID: 72171, updated on 11-Apr-2024

Summary

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Official Symbol
Shq1provided by MGI
Official Full Name
SHQ1 homolog (S. cerevisiae)provided by MGI
Primary source
MGI:MGI:1919421
See related
Ensembl:ENSMUSG00000035378 AllianceGenome:MGI:1919421
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Grim-1; 2810403P18Rik
Summary
Predicted to enable unfolded protein binding activity. Predicted to be involved in box H/ACA snoRNP assembly. Predicted to act upstream of or within negative regulation of rRNA processing and positive regulation of apoptotic process. Predicted to be located in cytosol. Predicted to be active in cytoplasm and nucleoplasm. Is expressed in midbrain ventricular layer; olfactory epithelium; submandibular gland primordium; and telencephalon ventricular layer. Orthologous to human SHQ1 (SHQ1, H/ACA ribonucleoprotein assembly factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14 (RPKM 2.7), CNS E11.5 (RPKM 2.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 D3; 6 46.82 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (100548772..100648135, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (100571811..100671183, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700049E22 gene Neighboring gene predicted gene, 33741 Neighboring gene STARR-seq mESC enhancer starr_16870 Neighboring gene ubiquitin-conjugating enzyme E2 variant 2 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr6:100621045-100621346 Neighboring gene glucoside xylosyltransferase 2 Neighboring gene high mobility group box 3 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E1325 Neighboring gene STARR-positive B cell enhancer ABC_E2197 Neighboring gene STARR-seq mESC enhancer starr_16873 Neighboring gene protein phosphatase 4, regulatory subunit 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Carninci P, et al. Genome Res, 2003 Jun. PMID 12819125, Free PMC Article
  2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in box H/ACA snoRNP assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of rRNA processing ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein-RNA complex assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein SHQ1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181590.5 → NP_853621.2  protein SHQ1 homolog

    See identical proteins and their annotated locations for NP_853621.2

    Status: VALIDATED

    Source sequence(s)
    AC162389, AK012978, BY776788, CB522035, CF746515
    Consensus CDS
    CCDS39580.2
    UniProtKB/Swiss-Prot
    Q7TMX5
    Related
    ENSMUSP00000127797.2, ENSMUST00000170667.8
    Conserved Domains (3) summary
    cd00298
    Location:9 → 78
    ACD_sHsps_p23-like; This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, ...
    pfam04925
    Location:245 → 414
    SHQ1; SHQ1 protein
    cl21457
    Location:179 → 266
    TIM_phosphate_binding; TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    100548772..100648135 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506669.5 → XP_006506732.1  protein SHQ1 homolog isoform X2

    UniProtKB/Swiss-Prot
    Q7TMX5
    Related
    ENSMUSP00000086656.7, ENSMUST00000089245.7
    Conserved Domains (2) summary
    cd00298
    Location:9 → 78
    ACD_sHsps_p23-like; This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, ...
    pfam04925
    Location:244 → 305
    SHQ1; SHQ1 protein

  2. XM_006506668.5 → XP_006506731.1  protein SHQ1 homolog isoform X1

    Conserved Domains (3) summary
    cd00298
    Location:9 → 78
    ACD_sHsps_p23-like; This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, ...
    pfam04925
    Location:245 → 407
    SHQ1; SHQ1 protein
    cl21457
    Location:179 → 266
    TIM; TIM-like beta/alpha barrel domains

  3. XM_006506670.5 → XP_006506733.1  protein SHQ1 homolog isoform X3

    Conserved Domains (3) summary
    cd00298
    Location:9 → 78
    ACD_sHsps_p23-like; This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, ...
    pfam04925
    Location:245 → 358
    SHQ1; SHQ1 protein
    cl21457
    Location:179 → 266
    TIM; TIM-like beta/alpha barrel domains
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TMX5.2 GenPept UniProtKB/Swiss-Prot:Q7TMX5

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