U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Thumpd2 THUMP domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 72167, updated on 21-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Thumpd2provided by MGI
Official Full Name
THUMP domain containing 2provided by MGI
Primary source
MGI:MGI:1919417
See related
Ensembl:ENSMUSG00000024246 AllianceGenome:MGI:1919417
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2810025A12Rik
Summary
Predicted to enable tRNA (guanine) methyltransferase activity. Predicted to be involved in tRNA methylation. Predicted to act upstream of or within methylation. Orthologous to human THUMPD2 (THUMP domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
17 E3; 17 51.04 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (81331676..81372542, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (81024247..81065113, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_43336 Neighboring gene nuclear transport factor 2 pseudogene Neighboring gene transmembrane protein 178 Neighboring gene STARR-seq mESC enhancer starr_43337 Neighboring gene STARR-seq mESC enhancer starr_43338 Neighboring gene predicted gene, 53963 Neighboring gene STARR-seq mESC enhancer starr_43339 Neighboring gene predicted gene, 33944

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Genomic variants in an inbred mouse model predict mania-like behaviors. Saul MC, et al. PLoS One, 2018. PMID 29768498, Free PMC Article
  2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Spontaneous (1)  1 citation
  • Endonuclease-mediated (2) 

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables tRNA (guanine) methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

Go to the top of the page Help
Preferred Names
THUMP domain-containing protein 2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028138.1 → NP_082414.1  THUMP domain-containing protein 2

    See identical proteins and their annotated locations for NP_082414.1

    Status: VALIDATED

    Source sequence(s)
    AC165966, AK012806, BY133372
    Consensus CDS
    CCDS50190.1
    UniProtKB/Swiss-Prot
    Q9CZB3
    Related
    ENSMUSP00000025093.5, ENSMUST00000025093.6
    Conserved Domains (3) summary
    cd11715
    Location:18 → 76
    THUMP_AdoMetMT; THUMP domain associated with S-adenosylmethionine-dependent methyltransferases
    smart00981
    Location:203 → 264
    THUMP; The THUMP domain is named after after thiouridine synthases, methylases and PSUSs
    cl17173
    Location:274 → 419
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    81331676..81372542 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011246636.4 → XP_011244938.1  THUMP domain-containing protein 2 isoform X1

    Conserved Domains (3) summary
    cd11715
    Location:18 → 76
    THUMP_AdoMetMT; THUMP domain associated with S-adenosylmethionine-dependent methyltransferases
    smart00981
    Location:203 → 264
    THUMP; The THUMP domain is named after after thiouridine synthases, methylases and PSUSs
    cl17173
    Location:274 → 423
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  2. XM_030250061.2 → XP_030105921.1  THUMP domain-containing protein 2 isoform X3

    Conserved Domains (2) summary
    smart00981
    Location:143 → 204
    THUMP; The THUMP domain is named after after thiouridine synthases, methylases and PSUSs
    cl17173
    Location:214 → 359
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  3. XM_011246637.4 → XP_011244939.1  THUMP domain-containing protein 2 isoform X2

    Conserved Domains (2) summary
    smart00981
    Location:143 → 204
    THUMP; The THUMP domain is named after after thiouridine synthases, methylases and PSUSs
    cl17173
    Location:214 → 363
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  4. XM_017317655.2 → XP_017173144.1  THUMP domain-containing protein 2 isoform X7

    Conserved Domains (1) summary
    cl17173
    Location:6 → 155
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  5. XM_036160790.1 → XP_036016683.1  THUMP domain-containing protein 2 isoform X5

    Conserved Domains (1) summary
    cl17173
    Location:66 → 215
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  6. XM_017317656.3 → XP_017173145.1  THUMP domain-containing protein 2 isoform X8

    Conserved Domains (2) summary
    cd11715
    Location:18 → 76
    THUMP_AdoMetMT; THUMP domain associated with S-adenosylmethionine-dependent methyltransferases
    cl17173
    Location:203 → 317
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  7. XM_011246639.4 → XP_011244941.1  THUMP domain-containing protein 2 isoform X4

    Conserved Domains (2) summary
    cd11715
    Location:18 → 76
    THUMP_AdoMetMT; THUMP domain associated with S-adenosylmethionine-dependent methyltransferases
    cl17173
    Location:203 → 364
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  8. XM_036160791.1 → XP_036016684.1  THUMP domain-containing protein 2 isoform X6

    Conserved Domains (2) summary
    cd11715
    Location:18 → 76
    THUMP_AdoMetMT; THUMP domain associated with S-adenosylmethionine-dependent methyltransferases
    smart00981
    Location:203 → 264
    THUMP; The THUMP domain is named after after thiouridine synthases, methylases and PSUSs

RNA

  1. XR_003952188.2 RNA Sequence

  2. XR_001782115.3 RNA Sequence

  3. XR_876548.3 RNA Sequence

  4. XR_001782116.3 RNA Sequence

  5. XR_004939583.1 RNA Sequence

  6. XR_003952189.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CZB3.3 GenPept UniProtKB/Swiss-Prot:Q9CZB3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous