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Cenpn centromere protein N [ Mus musculus (house mouse) ]

Gene ID: 72155, updated on 5-Mar-2024

Summary

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Official Symbol
Cenpnprovided by MGI
Official Full Name
centromere protein Nprovided by MGI
Primary source
MGI:MGI:1919405
See related
Ensembl:ENSMUSG00000031756 AllianceGenome:MGI:1919405
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2610510J17Rik
Summary
Predicted to be involved in chromosome segregation and kinetochore assembly. Predicted to be located in nucleoplasm. Orthologous to human CENPN (centromere protein N). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 55.4), CNS E11.5 (RPKM 13.8) and 8 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 E1; 8 63.34 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (117648448..117668243)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (116921716..116941504)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene translation machinery-associated protein 7 pseudogene Neighboring gene predicted gene, 42045 Neighboring gene C-X9-C motif containing 2 Neighboring gene STARR-seq mESC enhancer starr_22803 Neighboring gene STARR-positive B cell enhancer ABC_E6690 Neighboring gene ATM interactor Neighboring gene RIKEN cDNA 1700030J22 gene Neighboring gene STARR-positive B cell enhancer ABC_E2878

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
  2. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in CENP-A containing chromatin assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in chromosome segregation NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
  
part_of inner kinetochore ISO
Inferred from Sequence Orthology
more info
  
located_in kinetochore IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
centromere protein N
Names
CENP-N

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028131.3 → NP_082407.1  centromere protein N

    See identical proteins and their annotated locations for NP_082407.1

    Status: PROVISIONAL

    Source sequence(s)
    AC121101, AC162858
    Consensus CDS
    CCDS22693.1
    UniProtKB/Swiss-Prot
    Q6PE73, Q8R2W7, Q9CZW2
    Related
    ENSMUSP00000034205.5, ENSMUST00000034205.5
    Conserved Domains (1) summary
    pfam05238
    Location:3 → 337
    CENP-N; Kinetochore protein CHL4 like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    117648448..117668243
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154305.1 → XP_036010198.1  centromere protein N isoform X2

    Conserved Domains (1) summary
    pfam05238
    Location:4 → 211
    CENP-N; Kinetochore protein CHL4 like

  2. XM_006531387.4 → XP_006531450.1  centromere protein N isoform X1

    See identical proteins and their annotated locations for XP_006531450.1

    UniProtKB/Swiss-Prot
    Q6PE73, Q8R2W7, Q9CZW2
    Conserved Domains (1) summary
    pfam05238
    Location:3 → 337
    CENP-N; Kinetochore protein CHL4 like
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CZW2.1 GenPept UniProtKB/Swiss-Prot:Q9CZW2

Gene LinkOut

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