Adpgk ADP-dependent glucokinase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adpgkprovided by MGI
Official Full Name: ADP-dependent glucokinaseprovided by MGI
Primary source: MGI:MGI:1919391
See related: Ensembl:ENSMUSG00000025236 AllianceGenome:MGI:1919391
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Adp-gk; 2610017G09Rik
Summary: Enables ADP-specific glucokinase activity. Acts upstream of or within glucose metabolic process. Predicted to be located in extracellular region. Predicted to be active in endoplasmic reticulum. Is expressed in axial musculature and orbito-sphenoid. Orthologous to human ADPGK (ADP dependent glucokinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in liver E18 (RPKM 16.1), limb E14.5 (RPKM 15.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 B; 9 32.01 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (59198855..59223483)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (59291572..59316200)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ADPGK is substrate inhibited by high glucose concentration and shows high specificity for glucose, with no activity for other sugars, as determined by NMR spectroscopy, including 2-deoxyglucose
Title: The Structural and Functional Characterization of Mammalian ADP-dependent Glucokinase.
Results suggest that sterol regulatory-element binding protein-1c is unlikely to be the mediator of the early insulin effect on glucokinase gene transcription.
Title: Insulin regulation of glucokinase gene expression: evidence against a role for sterol regulatory element binding protein 1 in primary hepatocytes.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH126187 (e-PCR)
- UniSTS:162895

C77577 (e-PCR)
- UniSTS:179908

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ADP-specific glucokinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ADP-specific glucokinase activity	IDA Inferred from Direct Assay more info	PubMed
enables ADP-specific glucokinase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphotransferase activity, alcohol group as acceptor	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glucose metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within glucose metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within glucose metabolic process	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within glycolytic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ADP-dependent glucokinase

Names: ATP-dependent glucokinase

NP_001346211.1

EC 2.7.1.147

NP_082397.1

EC 2.7.1.147

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001359282.1 → NP_001346211.1 ADP-dependent glucokinase isoform 2 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice site in the coding region, compared to variant (1), encodes a protein (isoform 2) that is one amino acid shorter, compared to isoform 1.

Source sequence(s)

BC094657, CT025587

Consensus CDS

CCDS90583.1

UniProtKB/TrEMBL

A0A0R4J064, Q3TJ10, Q3UDS7

Related

ENSMUSP00000026266.9, ENSMUST00000026266.9

Conserved Domains (1) summary

cd01938
Location:60 → 491

ADPGK_ADPPFK; ADP-dependent glucokinase (ADPGK) and phosphofructokinase (ADPPFK). ADPGK and ADPPFK are proteins that rely on ADP rather than ATP to donate a phosphoryl group. They are found in certain hyperthermophilic archaea and in higher eukaryotes. A functional ...
NM_028121.2 → NP_082397.1 ADP-dependent glucokinase isoform 1 precursor

See identical proteins and their annotated locations for NP_082397.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK011434, AK048904, BC094657

Consensus CDS

CCDS23248.1

UniProtKB/Swiss-Prot

Q8C7Y9, Q8VDL4, Q9D0H2

UniProtKB/TrEMBL

A0A1L1SSF2, Q3TJ10

Related

ENSMUSP00000149882.2, ENSMUST00000217570.2

Conserved Domains (1) summary

cd01938
Location:60 → 492

ADPGK_ADPPFK; ADP-dependent glucokinase (ADPGK) and phosphofructokinase (ADPPFK). ADPGK and ADPPFK are proteins that rely on ADP rather than ATP to donate a phosphoryl group. They are found in certain hyperthermophilic archaea and in higher eukaryotes. A functional ...