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Dennd2d DENN domain containing 2D [ Mus musculus (house mouse) ]

Gene ID: 72121, updated on 5-Mar-2024

Summary

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Official Symbol
Dennd2dprovided by MGI
Official Full Name
DENN domain containing 2Dprovided by MGI
Primary source
MGI:MGI:2181193
See related
Ensembl:ENSMUSG00000027901 AllianceGenome:MGI:2181193
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2010308M01Rik
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nucleoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and respiratory system. Orthologous to human DENND2D (DENN domain containing 2D). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 8.3), large intestine adult (RPKM 7.1) and 18 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 F2.3; 3 46.49 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (106389745..106410346)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (106482431..106503030)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_08646 Neighboring gene chitinase 3-like 3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_08647 Neighboring gene chitinase-like 6 Neighboring gene STARR-seq mESC enhancer starr_08648 Neighboring gene STARR-positive B cell enhancer ABC_E6101 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:106252568-106252751 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:106264918-106265101 Neighboring gene RIKEN cDNA 2010016I18 gene Neighboring gene STARR-seq mESC enhancer starr_08649 Neighboring gene choline/ethanolaminephosphotransferase 1 Neighboring gene STARR-seq mESC enhancer starr_08650 Neighboring gene STARR-positive B cell enhancer ABC_E6102 Neighboring gene DNA-damage regulated autophagy modulator 2 Neighboring gene STARR-seq mESC enhancer starr_08651 Neighboring gene STARR-seq mESC enhancer starr_08652 Neighboring gene STARR-seq mESC enhancer starr_08653 Neighboring gene ligand dependent nuclear receptor interacting factor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
  5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

General gene information

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Markers

Homology

Clone Names

  • MGC6915

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
DENN domain-containing protein 2D
Names
DENN/MADD domain containing 2D

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001093754.2 → NP_001087223.1  DENN domain-containing protein 2D isoform 2

    See identical proteins and their annotated locations for NP_001087223.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC140380, AK008546
    Consensus CDS
    CCDS51040.1
    UniProtKB/Swiss-Prot
    Q3U028, Q91VV4, Q9D831
    Related
    ENSMUSP00000029508.5, ENSMUST00000029508.11
    Conserved Domains (3) summary
    smart00801
    Location:369 → 434
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:47 → 139
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:147 → 330
    DENN; DENN (AEX-3) domain

  2. NM_001278941.1 → NP_001265870.1  DENN domain-containing protein 2D isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an alternate 5' UTR and uses a downstream start codon compared to variant 1. It encodes isoform 3 which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC140380, AK008546, AK050033
    UniProtKB/Swiss-Prot
    Q91VV4
    Conserved Domains (2) summary
    smart00801
    Location:192 → 257
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:4 → 153
    DENN; DENN (AEX-3) domain

  3. NM_028110.2 → NP_082386.2  DENN domain-containing protein 2D isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shortest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC140380
    Consensus CDS
    CCDS17722.2
    UniProtKB/Swiss-Prot
    Q3U028, Q91VV4, Q9D831
    UniProtKB/TrEMBL
    S4R219
    Related
    ENSMUSP00000138462.2, ENSMUST00000183271.2
    Conserved Domains (3) summary
    smart00801
    Location:379 → 444
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:57 → 149
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:157 → 340
    DENN; DENN (AEX-3) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    106389745..106410346
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252838.2 → XP_030108698.1  DENN domain-containing protein 2D isoform X1

    Conserved Domains (3) summary
    smart00801
    Location:318 → 383
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:96 → 279
    DENN; DENN (AEX-3) domain
    cl04085
    Location:66 → 88
    uDENN; uDENN domain

RNA

  1. XR_003954399.2 RNA Sequence

  2. XR_003954396.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91VV4.1 GenPept UniProtKB/Swiss-Prot:Q91VV4

Gene LinkOut

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