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TRX-CAT2-1 tRNA-iMet (anticodon CAT) 2-1 [ Homo sapiens (human) ]

Gene ID: 7212, updated on 29-Mar-2023

Summary

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Official Symbol
TRX-CAT2-1provided by HGNC
Official Full Name
tRNA-iMet (anticodon CAT) 2-1provided by HGNC
Primary source
HGNC:HGNC:12322
See related
MIM:180620; AllianceGenome:HGNC:12322
Gene type
tRNA
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TRM1; RNTMI; TRMI1; RNTMI2; TRNAM2; TRNAMI1; TRNAMI2
Summary
Santos and Zasloff (1981) [PubMed 6261953] identified 12 initiator methionine tRNA genes, symbolized tRNA-i(met), in the haploid human genome. Zasloff et al. (1982) [PubMed 6923137] found a variant tRNA-i(met) with a G-to-T transversion in the highly conserved TCGA sequence in loop 4, a sequence position occupied exclusively by a purine (usually G) in almost 200 prokaryotic and eukaryotic tRNAs. One functional consequence of this base substitution is reduction in the rate of processing of the primary transcript of the gene. A second, demonstrated by microinjection into the germinal vesicle of the intact Xenopus laevis oocyte, is blockage of egress from the nucleus. It has been estimated that the human haploid genome contains 1,000 to 2,000 tRNA genes and that there are 50 to 60 chromatographically distinct tRNA species. These observations suggest redundancy of some tRNA genes. The studies of initiator methionine tRNA genes bear out this suspicion.[supplied by OMIM, Sep 2009]
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Genomic context

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See TRX-CAT2-1 in Genome Data Viewer
Location:
6p22.1
Annotation release Status Assembly Chr Location
109.20211119 latest, but not current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (27777885..27777956)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (27745664..27745735)

Bibliography

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Related articles in PubMed

  1. Impaired nuclear transport of a human variant tRNAiMet. Zasloff M, et al. Nature, 1982 Nov 4. PMID 6923137
  2. Two nonallelic tRNAiMet genes are located in the p23 leads to q12 region of human chromosome 6. Naylor SL, et al. Proc Natl Acad Sci U S A, 1983 Aug. PMID 6308668, Free PMC Article
  3. Comparative analysis of human chromosomal segments bearing nonallelic dispersed tRNAimet genes. Santos T, et al. Cell, 1981 Mar. PMID 6261953
  4. GtRNAdb: a database of transfer RNA genes detected in genomic sequence. Chan PP, et al. Nucleic Acids Res, 2009 Jan. PMID 18984615, Free PMC Article

GeneRIFs: Gene References Into Functions

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Markers

Other Names

  • tRNA methionine initiator 1
  • tRNA-iMet-CAT-2-1
  • transfer RNA initiator methionine (CAT) 2-1
  • transfer RNA methionine 2 (anticodon CAU)
  • transfer RNA methionine initiator 1 (anticodon CAU)
  • transfer RNA-iMet (CAT) 2-1
Nucleotide Protein
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