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Naa50 N(alpha)-acetyltransferase 50, NatE catalytic subunit [ Mus musculus (house mouse) ]

Gene ID: 72117, updated on 5-Mar-2024

Summary

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Official Symbol
Naa50provided by MGI
Official Full Name
N(alpha)-acetyltransferase 50, NatE catalytic subunitprovided by MGI
Primary source
MGI:MGI:1919367
See related
Ensembl:ENSMUSG00000022698 AllianceGenome:MGI:1919367
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
San; Mak3; Nat5; Mak3p; Nat13; 2600005K24Rik; 2810441M03Rik
Summary
Predicted to enable H4 histone acetyltransferase activity; peptide alpha-N-acetyltransferase activity; and peptidyl-lysine acetyltransferase activity. Predicted to be involved in mitotic sister chromatid cohesion and protein acetylation. Predicted to be located in cytosol and nucleus. Predicted to be part of NatA complex. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; integumental system; nose; respiratory system; and telencephalon. Orthologous to human NAA50 (N-alpha-acetyltransferase 50, NatE catalytic subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 17.1), liver E14 (RPKM 15.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
16 B4; 16 28.47 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (43960154..43983825)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (44139791..44163462)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene GRAM domain containing 1C Neighboring gene microRNA 3470b Neighboring gene STARR-seq mESC enhancer starr_40890 Neighboring gene STARR-seq mESC enhancer starr_40891 Neighboring gene STARR-seq mESC enhancer starr_40894 Neighboring gene ATPase, H+ transporting, lysosomal V1 subunit A Neighboring gene STARR-seq mESC enhancer starr_40895 Neighboring gene STARR-positive B cell enhancer ABC_E9932 Neighboring gene STARR-seq mESC enhancer starr_40896 Neighboring gene STARR-positive B cell enhancer ABC_E11613 Neighboring gene STARR-positive B cell enhancer ABC_E2462 Neighboring gene upstream transcription factor family member 3 Neighboring gene SID1 transmembrane family, member 1 Neighboring gene STARR-seq mESC enhancer starr_40897

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. NatC Nalpha-terminal acetyltransferase of yeast contains three subunits, Mak3p, Mak10p, and Mak31p. Polevoda B, et al. J Biol Chem, 2001 Jun 8. PMID 11274203
  2. Cloning and characterization of hNAT5/hSAN: an evolutionarily conserved component of the NatA protein N-alpha-acetyltransferase complex. Arnesen T, et al. Gene, 2006 Apr 26. PMID 16507339
  3. Embryonic growth-associated protein is one subunit of a novel N-terminal acetyltransferase complex essential for embryonic vascular development. Wenzlau JM, et al. Circ Res, 2006 Mar 31. PMID 16484612
  4. The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis. Sansom SN, et al. PLoS Genet, 2009 Jun. PMID 19521500, Free PMC Article
  5. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
Inferred from Electronic Annotation
more info
  
enables histone H4 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables peptide alpha-N-acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables peptidyl-lysine acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in N-terminal protein amino acid acetylation ISO
Inferred from Sequence Orthology
more info
  
involved_in N-terminal protein amino acid acetylation TAS
Traceable Author Statement
more info
 PubMed 
involved_in establishment of mitotic sister chromatid cohesion ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic sister chromatid cohesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic sister chromatid cohesion, centromeric ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of NatA complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of NatA complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
N-alpha-acetyltransferase 50
Names
Mak3 homolog
Mak3p homolog
N-acetyltransferase 13
N-acetyltransferase NAT13
N-epsilon-acetyltransferase 50
Nalpha acetyltransferase 50
natE catalytic subunit
NP_001334168.1
NP_082384.1
XP_036016025.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347239.1 → NP_001334168.1  N-alpha-acetyltransferase 50 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC125098, AK167141, AK168394, BC057117, BF020411
    Consensus CDS
    CCDS84236.1
    UniProtKB/Swiss-Prot
    Q3TH79, Q3TK59, Q6PGB6, Q7TML2, Q80VE3, Q9D0Q8
    Related
    ENSMUSP00000124291.2, ENSMUST00000161326.8
    Conserved Domains (1) summary
    COG0456
    Location:10 → 145
    RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]

  2. NM_028108.3 → NP_082384.1  N-alpha-acetyltransferase 50 isoform 1

    See identical proteins and their annotated locations for NP_082384.1

    Status: VALIDATED

    Source sequence(s)
    AC125098
    Consensus CDS
    CCDS28183.1
    UniProtKB/Swiss-Prot
    Q6PGB6
    Related
    ENSMUSP00000070140.9, ENSMUST00000063520.15
    Conserved Domains (1) summary
    COG0456
    Location:9 → 144
    RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    43960154..43983825
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160132.1 → XP_036016025.1  N-alpha-acetyltransferase 50 isoform X1

    Related
    ENSMUSP00000125517.2, ENSMUST00000159514.8
    Conserved Domains (1) summary
    COG0456
    Location:16 → 151
    RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PGB6.1 GenPept UniProtKB/Swiss-Prot:Q6PGB6

Gene LinkOut

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