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Zbed3 zinc finger, BED type containing 3 [ Mus musculus (house mouse) ]

Gene ID: 72114, updated on 5-Mar-2024

Summary

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Official Symbol
Zbed3provided by MGI
Official Full Name
zinc finger, BED type containing 3provided by MGI
Primary source
MGI:MGI:1919364
See related
Ensembl:ENSMUSG00000041995 AllianceGenome:MGI:1919364
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
0610037K01Rik; 2610005H11Rik
Summary
This gene encodes a member of the zinc finger protein superfamily. This protein may regulate the Wnt/beta-catenin signaling pathway. This protein may be involved in insulin resistance and type 2 diabetes in humans. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Expression
Broad expression in ovary adult (RPKM 63.5), limb E14.5 (RPKM 22.0) and 22 other tissues See more
Orthologs
human all
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Genomic context

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Location:
13 D1; 13 49.38 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (95460113..95474350)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (95323605..95337842)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene WD repeat domain 41 Neighboring gene predicted gene, 48350 Neighboring gene phosphodiesterase 8B Neighboring gene predicted gene, 41025 Neighboring gene STARR-positive B cell enhancer ABC_E10808 Neighboring gene STARR-positive B cell enhancer mm9_chr13:96117046-96117346 Neighboring gene small nucleolar RNA, H/ACA box 47 Neighboring gene predicted gene, 22661 Neighboring gene predicted gene, 53806 Neighboring gene STARR-positive B cell enhancer ABC_E7266 Neighboring gene angiogenic factor with G patch and FHA domains 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Zbed3 contributes to malignant phenotype of lung cancer via regulating β-catenin and P120-catenin 1. Fan C, et al. Mol Carcinog, 2015 Jun. PMID 25263389
  2. Zinc-finger BED domain-containing 3 (Zbed3) is a novel secreted protein associated with insulin resistance in humans. Jia Y, et al. J Intern Med, 2014 May. PMID 24283382
  3. Zbed3 Is Indispensable for Wnt Signaling Regulation of Cortical Layers Formation in Developing Brain. Ruan X, et al. Cereb Cortex, 2021 Jul 29. PMID 33822906
  4. Long noncoding RNA ZBED3-AS1 restrains breast cancer progression by targeting the microRNA-513a-5p/KLF6 axis. Fu A, et al. Thorac Cancer, 2021 Oct. PMID 34427978, Free PMC Article
  5. The subcortical maternal complex protein Nlrp4f is involved in cytoplasmic lattice formation and organelle distribution. Qin D, et al. Development, 2019 Oct 18. PMID 31575650

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Zbed3 Is Indispensable for Wnt Signaling Regulation of Cortical Layers Formation in Developing Brain.
    Title: Zbed3 Is Indispensable for Wnt Signaling Regulation of Cortical Layers Formation in Developing Brain.
  2. Long noncoding RNA ZBED3-AS1 restrains breast cancer progression by targeting the microRNA-513a-5p/KLF6 axis.
    Title: Long noncoding RNA ZBED3-AS1 restrains breast cancer progression by targeting the microRNA-513a-5p/KLF6 axis.
  3. The loss of maternal Zbed3 results in asymmetric zygotic division and abnormal distributions of organelles in the affected oocytes and zygotes, similar to the phenotypes observed in females with disrupted core subcortical maternal complex genes.
    Title: Zbed3 participates in the subcortical maternal complex and regulates the distribution of organelles.
  4. Zbed3 is a novel Axin-binding protein that is involved in Wnt/beta-catenin signaling modulation.
    Title: Identification of zinc-finger BED domain-containing 3 (Zbed3) as a novel Axin-interacting protein that activates Wnt/beta-catenin signaling.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in actin filament organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endoplasmic reticulum localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment of spindle localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrion localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of protein phosphorylation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within positive regulation of canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within protein stabilization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to glucose ISO
Inferred from Sequence Orthology
more info
  
involved_in response to insulin ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
zinc finger BED domain-containing protein 3
Names
axin-interacting protein
zinc finger, BED domain containing 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001302538.1 → NP_001289467.1  zinc finger BED domain-containing protein 3

    See identical proteins and their annotated locations for NP_001289467.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK162164, AK162256, BC085478
    Consensus CDS
    CCDS26696.1
    UniProtKB/Swiss-Prot
    Q9D0L1
    UniProtKB/TrEMBL
    Q3TSB2, Q3UTC5
    Related
    ENSMUSP00000152153.2, ENSMUST00000221807.2
    Conserved Domains (2) summary
    smart00614
    Location:37 → 91
    ZnF_BED; BED zinc finger
    PRK12704
    Location:136 → 189
    PRK12704; phosphodiesterase; Provisional

  2. NM_001302539.1 → NP_001289468.1  zinc finger BED domain-containing protein 3

    See identical proteins and their annotated locations for NP_001289468.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC133188, AK162164, BC085478, BY093894
    Consensus CDS
    CCDS26696.1
    UniProtKB/Swiss-Prot
    Q9D0L1
    UniProtKB/TrEMBL
    Q3TSB2, Q3UTC5
    Conserved Domains (2) summary
    smart00614
    Location:37 → 91
    ZnF_BED; BED zinc finger
    PRK12704
    Location:136 → 189
    PRK12704; phosphodiesterase; Provisional

  3. NM_028106.3 → NP_082382.1  zinc finger BED domain-containing protein 3

    See identical proteins and their annotated locations for NP_082382.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK011319, AK162164, BC085478, BU709250, BY776906, BY776946
    Consensus CDS
    CCDS26696.1
    UniProtKB/Swiss-Prot
    Q9D0L1
    UniProtKB/TrEMBL
    Q3TSB2, Q3UTC5
    Related
    ENSMUSP00000044774.8, ENSMUST00000045909.8
    Conserved Domains (2) summary
    smart00614
    Location:37 → 91
    ZnF_BED; BED zinc finger
    PRK12704
    Location:136 → 189
    PRK12704; phosphodiesterase; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    95460113..95474350
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247416.2 → XP_030103276.1  zinc finger BED domain-containing protein 3 isoform X1

    UniProtKB/Swiss-Prot
    Q9D0L1
    UniProtKB/TrEMBL
    Q3TSB2, Q3UTC5
    Conserved Domains (2) summary
    smart00614
    Location:37 → 91
    ZnF_BED; BED zinc finger
    PRK12704
    Location:136 → 189
    PRK12704; phosphodiesterase; Provisional
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D0L1.1 GenPept UniProtKB/Swiss-Prot:Q9D0L1

Gene LinkOut

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