Dscc1 DNA replication and sister chromatid cohesion 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dscc1provided by MGI
Official Full Name: DNA replication and sister chromatid cohesion 1provided by MGI
Primary source: MGI:MGI:1919357
See related: Ensembl:ENSMUSG00000022422 AllianceGenome:MGI:1919357
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Dcc1; 2010006I05Rik; 2600005O03Rik
Summary: Predicted to enable DNA binding activity. Predicted to contribute to DNA clamp loader activity and single-stranded DNA helicase activity. Predicted to be involved in maintenance of mitotic sister chromatid cohesion; positive regulation of DNA-directed DNA polymerase activity; and post-translational protein acetylation. Predicted to act upstream of or within DNA replication. Predicted to be located in nucleoplasm. Predicted to be part of Ctf18 RFC-like complex. Predicted to be active in chromatin; chromosome, centromeric region; and nucleus. Is expressed in brain. Orthologous to human DSCC1 (DNA replication and sister chromatid cohesion 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver E14 (RPKM 4.6), CNS E11.5 (RPKM 4.2) and 14 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 D1; 15 21.96 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (54939497..54953887, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (55076101..55090491, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)
Endonuclease-mediated (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
contributes_to DNA clamp loader activity	ISO Inferred from Sequence Orthology more info
contributes_to single-stranded DNA helicase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA replication	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
involved_in maintenance of mitotic sister chromatid cohesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in maintenance of mitotic sister chromatid cohesion	ISO Inferred from Sequence Orthology more info
involved_in mitotic sister chromatid cohesion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-directed DNA polymerase activity	ISO Inferred from Sequence Orthology more info
involved_in post-translational protein acetylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA replication	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of Ctf18 RFC-like complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Ctf18 RFC-like complex	ISO Inferred from Sequence Orthology more info
part_of chromatin	IBA Inferred from Biological aspect of Ancestor more info
part_of chromatin	ISO Inferred from Sequence Orthology more info
is_active_in chromosome, centromeric region	IBA Inferred from Biological aspect of Ancestor more info
located_in chromosome, centromeric region	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: sister chromatid cohesion protein DCC1

Names: defective in sister chromatid cohesion 1 homolog; defective in sister chromatid cohesion protein 1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001355594.1 → NP_001342523.1 sister chromatid cohesion protein DCC1 isoform 1

Status: VALIDATED

Source sequence(s)

AC137950

Consensus CDS

CCDS88764.1

UniProtKB/TrEMBL

D3YVY9

Related

ENSMUSP00000105860.2, ENSMUST00000110231.2

Conserved Domains (1) summary

pfam09724
Location:49 → 426

DUF2036; Uncharacterized conserved protein (DUF2036)
NM_183089.3 → NP_898912.2 sister chromatid cohesion protein DCC1 isoform 2

See identical proteins and their annotated locations for NP_898912.2

Status: VALIDATED

Source sequence(s)

AC137950

Consensus CDS

CCDS27473.1

UniProtKB/Swiss-Prot

Q14AI0, Q4FZL5

Related

ENSMUSP00000023059.7, ENSMUST00000023059.13

Conserved Domains (1) summary

pfam09724
Location:49 → 363

DUF2036; Uncharacterized conserved protein (DUF2036)