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Eef1akmt2 EEF1A lysine methyltransferase 2 [ Mus musculus (house mouse) ]

Gene ID: 72096, updated on 11-Apr-2024

Summary

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Official Symbol
Eef1akmt2provided by MGI
Official Full Name
EEF1A lysine methyltransferase 2provided by MGI
Primary source
MGI:MGI:1919346
See related
Ensembl:ENSMUSG00000030960 AllianceGenome:MGI:1919346
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mettl10; 2010208K18Rik
Summary
Predicted to enable protein-lysine N-methyltransferase activity. Predicted to be involved in peptidyl-lysine dimethylation and peptidyl-lysine monomethylation. Predicted to act upstream of or within methylation. Predicted to be located in cytosol and nuclear body. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and immune system. Orthologous to human EEF1AKMT2 (EEF1A lysine methyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 12.3), CNS E14 (RPKM 12.0) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 F3; 7 76.31 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (132429186..132454376, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (132827457..132853299, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8216 Neighboring gene predicted gene, 46021 Neighboring gene phospholysine phosphohistidine inorganic pyrophosphate phosphatase Neighboring gene STARR-positive B cell enhancer mm9_chr7:139848293-139848593 Neighboring gene STARR-seq mESC enhancer starr_20301 Neighboring gene STARR-seq mESC enhancer starr_20302 Neighboring gene family with sequence similarity 53, member B Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:140044265-140044448 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:140050715-140050898 Neighboring gene RIKEN cDNA 1500002F19 gene Neighboring gene BRISC complex subunit Neighboring gene STARR-seq mESC enhancer starr_20305 Neighboring gene predicted gene, 46003

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Head bobber: an insertional mutation causes inner ear defects, hyperactive circling, and deafness. Somma G, et al. J Assoc Res Otolaryngol, 2012 Jun. PMID 22383091, Free PMC Article
  2. A molecular profile of a hematopoietic stem cell niche. Hackney JA, et al. Proc Natl Acad Sci U S A, 2002 Oct 1. PMID 12226475, Free PMC Article
  3. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC144343

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-lysine N-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-lysine N-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in peptidyl-lysine methylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
EEF1A lysine methyltransferase 2
Names
methyltransferase like 10
methyltransferase-like protein 10
protein-lysine N-methyltransferase Mettl10
NP_001334558.1
NP_082371.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347629.1 → NP_001334558.1  EEF1A lysine methyltransferase 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two coding exons compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC099627
    Consensus CDS
    CCDS85439.1
    UniProtKB/TrEMBL
    A0A087WQ96, D3Z7D0
    Related
    ENSMUSP00000113039.2, ENSMUST00000120425.8

  2. NM_028095.1 → NP_082371.1  EEF1A lysine methyltransferase 2 isoform 1

    See identical proteins and their annotated locations for NP_082371.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK008476, BC038323, BQ830246
    Consensus CDS
    CCDS21927.1
    UniProtKB/Swiss-Prot
    Q4V9Y9, Q9D853
    Related
    ENSMUSP00000033257.9, ENSMUST00000033257.15
    Conserved Domains (2) summary
    COG0500
    Location:40 → 194
    SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
    pfam12847
    Location:80 → 192
    Methyltransf_18; Methyltransferase domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    132429186..132454376 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D853.1 GenPept UniProtKB/Swiss-Prot:Q9D853

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