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Pigx phosphatidylinositol glycan anchor biosynthesis, class X [ Mus musculus (house mouse) ]

Gene ID: 72084, updated on 5-Mar-2024

Summary

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Official Symbol
Pigxprovided by MGI
Official Full Name
phosphatidylinositol glycan anchor biosynthesis, class Xprovided by MGI
Primary source
MGI:MGI:1919334
See related
Ensembl:ENSMUSG00000023791 AllianceGenome:MGI:1919334
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PIG-X; 2010319C14Rik
Summary
This gene encodes a type I transmembrane protein in the endoplasmic reticulum (ER). The protein is an essential component of glycosylphosphatidylinositol-mannosyltransferase I, which transfers the first of the four mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Studies in rat indicate that the protein is translated from a non-AUG translation initiation site. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in CNS E14 (RPKM 20.4), placenta adult (RPKM 20.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
16 B2; 16 22.4 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (31903234..31918545, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (32084416..32099727, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene SUMO/sentrin specific peptidase 5 Neighboring gene high mobility group box 1, pseudogene 6 Neighboring gene STARR-seq mESC enhancer starr_40638 Neighboring gene p21 (RAC1) activated kinase 2 Neighboring gene STARR-positive B cell enhancer ABC_E7439 Neighboring gene predicted gene, 26419 Neighboring gene STARR-positive B cell enhancer ABC_E4164 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:32107830-32107983 Neighboring gene STARR-positive B cell enhancer ABC_E4165 Neighboring gene centrosomal protein 19 Neighboring gene STARR-seq mESC enhancer starr_40643 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:32130316-32130510 Neighboring gene STARR-positive B cell enhancer ABC_E7441 Neighboring gene negative regulator of reactive oxygen species

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Regulatory network analysis of hypertension and hypotension microarray data from mouse model. Zhu Y, et al. Clin Exp Hypertens, 2018. PMID 29400567
  2. Mammalian PIG-X and yeast Pbn1p are the essential components of glycosylphosphatidylinositol-mannosyltransferase I. Ashida H, et al. Mol Biol Cell, 2005 Mar. PMID 15635094, Free PMC Article
  3. Glycosylphosphatidylinositol biosynthesis and remodeling are required for neural tube closure, heart development, and cranial neural crest cell survival. Lukacs M, et al. Elife, 2019 Jun 24. PMID 31232685, Free PMC Article
  4. Behavioral changes and growth deficits in a CRISPR engineered mouse model of the schizophrenia-associated 3q29 deletion. Rutkowski TP, et al. Mol Psychiatry, 2021 Mar. PMID 30976085, Free PMC Article
  5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Sept6 and Pigx might participate in the pathogenesis of high blood pressure.
    Title: Regulatory network analysis of hypertension and hypotension microarray data from mouse model.
  2. A non-AUG translation initiation site (CUG) is used in rat Pigx
    Title: Mammalian PIG-X and yeast Pbn1p are the essential components of glycosylphosphatidylinositol-mannosyltransferase I.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within GPI anchor biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in GPI anchor biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
phosphatidylinositol-glycan biosynthesis class X protein
Names
phosphatidylinositol glycan, class X

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001111025.1 → NP_001104495.1  phosphatidylinositol-glycan biosynthesis class X protein isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in a shorter protein (isoform 2).
    Source sequence(s)
    BX525135, BY708475, CF581933
    Consensus CDS
    CCDS49824.1
    UniProtKB/TrEMBL
    A0A087WSN5, F6YX19
    Related
    ENSMUSP00000141122.3, ENSMUST00000189013.8
    Conserved Domains (1) summary
    pfam08320
    Location:48 → 244
    PIG-X; PIG-X / PBN1

  2. NM_024464.3 → NP_077784.2  phosphatidylinositol-glycan biosynthesis class X protein isoform 1 precursor

    See identical proteins and their annotated locations for NP_077784.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK008583, BY708475, CF581933
    Consensus CDS
    CCDS28113.2
    UniProtKB/Swiss-Prot
    Q99LV7
    UniProtKB/TrEMBL
    F7DFD7
    Related
    ENSMUSP00000093819.5, ENSMUST00000096109.11
    Conserved Domains (1) summary
    pfam08320
    Location:50 → 246
    PIG-X; PIG-X / PBN1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    31903234..31918545 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99LV7.2 GenPept UniProtKB/Swiss-Prot:Q99LV7

Gene LinkOut

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