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Mzt2 mitotic spindle organizing protein 2 [ Mus musculus (house mouse) ]

Gene ID: 72083, updated on 8-Feb-2024

Summary

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Official Symbol
Mzt2provided by MGI
Official Full Name
mitotic spindle organizing protein 2provided by MGI
Primary source
MGI:MGI:1922845
See related
Ensembl:ENSMUSG00000022671 AllianceGenome:MGI:1922845
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fam128; Fam128b; 2410018G20Rik; 2610001E06Rik
Summary
Predicted to be located in cytosol and nucleoplasm. Predicted to be part of gamma-tubulin large complex. Predicted to be active in centrosome and spindle. Orthologous to several human genes including MZT2B (mitotic spindle organizing protein 2B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 89.7), subcutaneous fat pad adult (RPKM 15.9) and 26 other tissues See more
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Genomic context

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See Mzt2 in Genome Data Viewer
Location:
16 A2; 16 10.09 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (15666305..15681233, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (15848441..15863369, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_40212 Neighboring gene minichromosome maintenance complex component 4 Neighboring gene protein kinase, DNA activated, catalytic polypeptide Neighboring gene predicted gene, 52255 Neighboring gene STARR-seq mESC enhancer starr_40215 Neighboring gene STARR-seq mESC enhancer starr_40216 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:15863142-15863251 Neighboring gene STARR-positive B cell enhancer ABC_E5527 Neighboring gene STARR-seq mESC enhancer starr_40217 Neighboring gene predicted gene, 41425 Neighboring gene 60S ribosomal protein L30-like Neighboring gene CCAAT/enhancer binding protein delta Neighboring gene scaffolding protein involved in DNA repair

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics. Federspiel JD, et al. Mol Cell Proteomics, 2019 Aug 9. PMID 31040226, Free PMC Article
  2. Systematic analysis of human protein complexes identifies chromosome segregation proteins. Hutchins JR, et al. Science, 2010 Apr 30. PMID 20360068, Free PMC Article
  3. The central role of EED in the orchestration of polycomb group complexes. Cao Q, et al. Nat Commun, 2014. PMID 24457600, Free PMC Article
  4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of gamma-tubulin ring complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in spindle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mitotic-spindle organizing protein 2
Names
family with sequence similarity 128, member B
mitotic-spindle organizing protein associated with a ring of gamma-tubulin 2
mitotic-spindle organizing protein associated with a ring of gamma-tubulin 2B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359003.1 → NP_001345932.1  mitotic-spindle organizing protein 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC154586
    Consensus CDS
    CCDS27979.1
    UniProtKB/Swiss-Prot
    Q9CQ25
    Related
    ENSMUSP00000113832.2, ENSMUST00000117136.2
    Conserved Domains (1) summary
    pfam12926
    Location:16 → 98
    MOZART2; Mitotic-spindle organizing gamma-tubulin ring associated

  2. NM_029354.3 → NP_083630.1  mitotic-spindle organizing protein 2

    See identical proteins and their annotated locations for NP_083630.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC154586
    Consensus CDS
    CCDS27979.1
    UniProtKB/Swiss-Prot
    Q9CQ25
    Related
    ENSMUSP00000023351.5, ENSMUST00000023351.11
    Conserved Domains (1) summary
    pfam12926
    Location:16 → 98
    MOZART2; Mitotic-spindle organizing gamma-tubulin ring associated

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    15666305..15681233 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CQ25.1 GenPept UniProtKB/Swiss-Prot:Q9CQ25

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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