Rap2c RAP2C, member of RAS oncogene family [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rap2cprovided by MGI
Official Full Name: RAP2C, member of RAS oncogene familyprovided by MGI
Primary source: MGI:MGI:1919315
See related: Ensembl:ENSMUSG00000050029 AllianceGenome:MGI:1919315
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2010200P20Rik
Summary: Predicted to enable GTPase activity; guanyl ribonucleotide binding activity; and transcription coactivator activity. Involved in Rap protein signal transduction and regulation of protein tyrosine kinase activity. Acts upstream of or within negative regulation of cell migration and positive regulation of protein autophosphorylation. Located in cytosol and recycling endosome membrane. Is expressed in 1st branchial arch mandibular component. Orthologous to human RAP2C (RAP2C, member of RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in placenta adult (RPKM 13.8), limb E14.5 (RPKM 10.4) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: X A5; X 28.03 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (50093163..50108966, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (51003912..51020091, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Rap2c GTPase facilitates B cell receptor-induced reorientation of the microtubule-organizing center.
Title: The Rap2c GTPase facilitates B cell receptor-induced reorientation of the microtubule-organizing center.
Study found that SCII upregulated the expression of miR-204 and downregulated the expression of RAP2C; that hypoxia increased the expression of miR-204 and decreased the expression of RAP2C, and overexpression of RAP2C attenuates the effect of hypoxia on apoptosis rate; and miR-204 could directly bind to RAP2C, and could regulate the expression of RAP2C.
Title: Spinal cord ischemia-reperfusion causes damage of neurocyte by inhibiting RAP2C.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein activity	IEA Inferred from Electronic Annotation more info
enables GDP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GDP binding	ISO Inferred from Sequence Orthology more info
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	ISO Inferred from Sequence Orthology more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Rap protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in Rap protein signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in establishment of endothelial intestinal barrier	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of cell migration	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in bicellular tight junction	ISO Inferred from Sequence Orthology more info
located_in cell-cell contact zone	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in recycling endosome	IDA Inferred from Direct Assay more info	PubMed
located_in recycling endosome membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ras-related protein Rap-2c

NP_001405293.1

EC 3.6.5.2

NP_766001.1

EC 3.6.5.2

XP_006541609.1

EC 3.6.5.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.