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Tmub2 transmembrane and ubiquitin-like domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 72053, updated on 5-Mar-2024

Summary

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Official Symbol
Tmub2provided by MGI
Official Full Name
transmembrane and ubiquitin-like domain containing 2provided by MGI
Primary source
MGI:MGI:1919303
See related
Ensembl:ENSMUSG00000034757 AllianceGenome:MGI:1919303
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2010008E23Rik
Summary
This gene encodes a predicted multi-pass membrane protein that features a C-terminal ubiquitin-related domain. This gene may be expressed in cone photoreceptors in the retina. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]
Expression
Ubiquitous expression in ovary adult (RPKM 29.9), large intestine adult (RPKM 19.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 D; 11 66.29 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (102175777..102180253)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (102284951..102289427)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E911 Neighboring gene homologous recombination factor with OB-fold Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:102128926-102129035 Neighboring gene ankyrin repeat and SOCS box-containing 16 Neighboring gene STARR-positive B cell enhancer ABC_E1432 Neighboring gene ataxin 7-like 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:102156604-102156807 Neighboring gene STARR-positive B cell enhancer ABC_E469 Neighboring gene predicted gene, 33851 Neighboring gene STARR-positive B cell enhancer ABC_E5281 Neighboring gene upstream binding transcription factor, RNA polymerase I

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A hybrid photoreceptor expressing both rod and cone genes in a mouse model of enhanced S-cone syndrome. Corbo JC, et al. PLoS Genet, 2005 Aug. PMID 16110338, Free PMC Article
  2. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862
  3. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
  4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  5. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transmembrane and ubiquitin-like domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001302505.2 → NP_001289434.1  transmembrane and ubiquitin-like domain-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001289434.1

    Status: VALIDATED

    Source sequence(s)
    AL954730
    Consensus CDS
    CCDS25494.1
    UniProtKB/Swiss-Prot
    A2AWT1, Q3V209, Q8K0X0, Q91YQ0, Q9D8C5
    UniProtKB/TrEMBL
    G8JL73
    Related
    ENSMUSP00000116327.2, ENSMUST00000156326.2
    Conserved Domains (2) summary
    smart00213
    Location:173 → 240
    UBQ; Ubiquitin homologues
    pfam00240
    Location:191 → 244
    ubiquitin; Ubiquitin family

  2. NM_001302506.2 → NP_001289435.2  transmembrane and ubiquitin-like domain-containing protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL954730
    UniProtKB/TrEMBL
    G8JL73
    Conserved Domains (1) summary
    cd17132
    Location:152 → 222
    Ubl_TMUB2; ubiquitin-like (Ubl) domain found in transmembrane and ubiquitin-like domain-containing protein 2 (TMUB2)

  3. NM_028076.4 → NP_082352.1  transmembrane and ubiquitin-like domain-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_082352.1

    Status: VALIDATED

    Source sequence(s)
    AL954730
    Consensus CDS
    CCDS25494.1
    UniProtKB/Swiss-Prot
    A2AWT1, Q3V209, Q8K0X0, Q91YQ0, Q9D8C5
    UniProtKB/TrEMBL
    G8JL73
    Related
    ENSMUSP00000047600.7, ENSMUST00000036376.13
    Conserved Domains (2) summary
    smart00213
    Location:173 → 240
    UBQ; Ubiquitin homologues
    pfam00240
    Location:191 → 244
    ubiquitin; Ubiquitin family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    102175777..102180253
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3V209.1 GenPept UniProtKB/Swiss-Prot:Q3V209

Gene LinkOut

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