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Urgcp upregulator of cell proliferation [ Mus musculus (house mouse) ]

Gene ID: 72046, updated on 5-Mar-2024

Summary

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Official Symbol
Urgcpprovided by MGI
Official Full Name
upregulator of cell proliferationprovided by MGI
Primary source
MGI:MGI:1919296
See related
Ensembl:ENSMUSG00000049680 AllianceGenome:MGI:1919296
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Urg4; mKIAA1507; 2010005J08Rik; 9130001I21Rik
Summary
Predicted to enable GTP binding activity. Predicted to be located in cytosol. Orthologous to human URGCP (upregulator of cell proliferation). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 12.8), duodenum adult (RPKM 12.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Urgcp in Genome Data Viewer
Location:
11 A1; 11 3.87 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (5663417..5712376, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (5713417..5762376, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53663 Neighboring gene mitochondrial ribosomal protein S24 Neighboring gene STARR-seq mESC enhancer starr_28441 Neighboring gene STARR-positive B cell enhancer ABC_E8385 Neighboring gene ubiquitin-conjugating enzyme E2D, pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E6945 Neighboring gene drebrin-like Neighboring gene STARR-seq mESC enhancer starr_28442 Neighboring gene phosphoglycerate mutase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
  2. An Interaction Landscape of Ubiquitin Signaling. Zhang X, et al. Mol Cell, 2017 Mar 2. PMID 28190767
  3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
up-regulator of cell proliferation
Names
HBV X protein up-regulated gene 4 protein homolog
HBxAg up-regulated gene 4 protein homolog
protein URG4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077661.1 → NP_001071129.1  up-regulator of cell proliferation isoform 2

    See identical proteins and their annotated locations for NP_001071129.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1. Variants 2-6 all encode the same isoform (2).
    Source sequence(s)
    AK041953, AL627069, BC066994
    Consensus CDS
    CCDS36105.1
    UniProtKB/TrEMBL
    Q6ZPP3
    Related
    ENSMUSP00000113060.2, ENSMUST00000120306.8
    Conserved Domains (2) summary
    cl27170
    Location:364 → 498
    DUF460; Protein of unknown function (DUF460)
    cl38936
    Location:649 → 749
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. NM_001361588.1 → NP_001348517.1  up-regulator of cell proliferation isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1. Variants 2-6 all encode the same isoform (2).
    Source sequence(s)
    AK041953, AL627069
    Consensus CDS
    CCDS36105.1
    UniProtKB/TrEMBL
    Q6ZPP3
    Related
    ENSMUSP00000113589.2, ENSMUST00000118076.8
    Conserved Domains (2) summary
    cl27170
    Location:364 → 498
    DUF460; Protein of unknown function (DUF460)
    cl38936
    Location:649 → 749
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  3. NM_001361589.1 → NP_001348518.1  up-regulator of cell proliferation isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1. Variants 2-6 all encode the same isoform (2).
    Source sequence(s)
    AL627069
    Consensus CDS
    CCDS36105.1
    UniProtKB/TrEMBL
    Q6ZPP3
    Conserved Domains (2) summary
    cl27170
    Location:364 → 498
    DUF460; Protein of unknown function (DUF460)
    cl38936
    Location:649 → 749
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  4. NM_001361590.1 → NP_001348519.1  up-regulator of cell proliferation isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1. Variants 2-6 all encode the same isoform (2).
    Source sequence(s)
    AL627069, BY036098
    Consensus CDS
    CCDS36105.1
    UniProtKB/TrEMBL
    Q6ZPP3
    Conserved Domains (2) summary
    cl27170
    Location:364 → 498
    DUF460; Protein of unknown function (DUF460)
    cl38936
    Location:649 → 749
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  5. NM_001361591.1 → NP_001348520.1  up-regulator of cell proliferation isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1. Variants 2-6 all encode the same isoform (2).
    Source sequence(s)
    AL627069, BY339716
    Consensus CDS
    CCDS36105.1
    UniProtKB/TrEMBL
    Q6ZPP3
    Conserved Domains (2) summary
    cl27170
    Location:364 → 498
    DUF460; Protein of unknown function (DUF460)
    cl38936
    Location:649 → 749
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  6. NM_001361592.1 → NP_001348521.1  up-regulator of cell proliferation isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AL627069, DN174878
    UniProtKB/TrEMBL
    Q6ZPP3
    Conserved Domains (2) summary
    cl27170
    Location:332 → 466
    DUF460; Protein of unknown function (DUF460)
    cl38936
    Location:617 → 717
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  7. NM_178623.3 → NP_848738.2  up-regulator of cell proliferation isoform 1

    See identical proteins and their annotated locations for NP_848738.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AL627069, BY058620
    Consensus CDS
    CCDS36104.1
    UniProtKB/Swiss-Prot
    A0PJ66, Q3TLI5, Q5NCI0, Q8C9K3, Q8CBP7, Q8CC98
    UniProtKB/TrEMBL
    Q6ZPP3
    Related
    ENSMUSP00000091053.6, ENSMUST00000093362.12
    Conserved Domains (1) summary
    cl21455
    Location:692 → 792
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    5663417..5712376 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157006.1 → XP_036012899.1  up-regulator of cell proliferation isoform X3

    UniProtKB/TrEMBL
    Q6ZPP3
    Conserved Domains (2) summary
    cl27170
    Location:364 → 498
    DUF460; Protein of unknown function (DUF460)
    cl38936
    Location:649 → 749
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. XM_006514815.4 → XP_006514878.1  up-regulator of cell proliferation isoform X3

    See identical proteins and their annotated locations for XP_006514878.1

    UniProtKB/TrEMBL
    Q6ZPP3
    Conserved Domains (2) summary
    cl27170
    Location:364 → 498
    DUF460; Protein of unknown function (DUF460)
    cl38936
    Location:649 → 749
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  3. XM_011243755.4 → XP_011242057.1  up-regulator of cell proliferation isoform X3

    See identical proteins and their annotated locations for XP_011242057.1

    UniProtKB/TrEMBL
    Q6ZPP3
    Conserved Domains (2) summary
    cl27170
    Location:364 → 498
    DUF460; Protein of unknown function (DUF460)
    cl38936
    Location:649 → 749
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  4. XM_011243754.4 → XP_011242056.1  up-regulator of cell proliferation isoform X2

    UniProtKB/TrEMBL
    Q6ZPP3
    Conserved Domains (2) summary
    cl27170
    Location:373 → 507
    DUF460; Protein of unknown function (DUF460)
    cl38936
    Location:658 → 758
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  5. XM_011243753.3 → XP_011242055.1  up-regulator of cell proliferation isoform X1

    UniProtKB/TrEMBL
    Q6ZPP3
    Conserved Domains (2) summary
    cl27170
    Location:377 → 511
    DUF460; Protein of unknown function (DUF460)
    cl38936
    Location:662 → 762
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  6. XM_011243757.3 → XP_011242059.1  up-regulator of cell proliferation isoform X4

    See identical proteins and their annotated locations for XP_011242059.1

    UniProtKB/TrEMBL
    Q6ZPP3
    Conserved Domains (2) summary
    cl27170
    Location:332 → 466
    DUF460; Protein of unknown function (DUF460)
    cl38936
    Location:617 → 717
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5NCI0.1 GenPept UniProtKB/Swiss-Prot:Q5NCI0

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