Cyb5r1 cytochrome b5 reductase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cyb5r1provided by MGI
Official Full Name: cytochrome b5 reductase 1provided by MGI
Primary source: MGI:MGI:1919267
See related: Ensembl:ENSMUSG00000026456 AllianceGenome:MGI:1919267
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: B5R.1; Nqo3a2; 1500005G05Rik
Summary: Predicted to enable FAD binding activity. Predicted to act upstream of or within sterol biosynthetic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; nervous system; nose; respiratory system; and urinary system. Orthologous to human CYB5R1 (cytochrome b5 reductase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in adrenal adult (RPKM 21.2), ovary adult (RPKM 17.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 E4; 1 58.21 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (134333519..134339476)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (134405781..134411738)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Membrane Damage during Ferroptosis Is Caused by Oxidation of Phospholipids Catalyzed by the Oxidoreductases POR and CYB5R1.
Title: Membrane Damage during Ferroptosis Is Caused by Oxidation of Phospholipids Catalyzed by the Oxidoreductases POR and CYB5R1.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables FAD binding	IBA Inferred from Biological aspect of Ancestor more info
enables cytochrome-b5 reductase activity, acting on NAD(P)H	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within steroid biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within steroid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sterol biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: NADH-cytochrome b5 reductase 1

Names: NAD(P)H:quinone oxidoreductase type 3, polypeptide A2

NP_001342062.1

EC 1.6.2.2

NP_082333.1

EC 1.6.2.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001355133.1 → NP_001342062.1 NADH-cytochrome b5 reductase 1 isoform 2

Status: VALIDATED

Source sequence(s)

AC131592

Conserved Domains (1) summary

cl26810
Location:5 → 268

PLN02252; nitrate reductase [NADPH]
NM_028057.3 → NP_082333.1 NADH-cytochrome b5 reductase 1 isoform 1

See identical proteins and their annotated locations for NP_082333.1

Status: VALIDATED

Source sequence(s)

AC131592, AK005159

Consensus CDS

CCDS15308.1

UniProtKB/Swiss-Prot

Q91W81, Q9DB73

Related

ENSMUSP00000027726.8, ENSMUST00000027726.14

Conserved Domains (2) summary

cd06183
Location:49 → 305

cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...

PTZ00319
Location:33 → 305

PTZ00319; NADH-cytochrome B5 reductase; Provisional