U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Tedc2 tubulin epsilon and delta complex 2 [ Mus musculus (house mouse) ]

Gene ID: 72016, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Tedc2provided by MGI
Official Full Name
tubulin epsilon and delta complex 2provided by MGI
Primary source
MGI:MGI:1919266
See related
Ensembl:ENSMUSG00000024118 AllianceGenome:MGI:1919266
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1600002H07Rik
Summary
Involved in positive regulation of smoothened signaling pathway. Located in centriole and cilium. Orthologous to human TEDC2 (tubulin epsilon and delta complex 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver adult (RPKM 18.6), liver E14.5 (RPKM 10.5) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
17 A3.3; 17 12.32 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (24434028..24439825, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (24215054..24220934, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8658 Neighboring gene ATPase, H+ transporting, lysosomal V0 subunit C Neighboring gene TBC1 domain family, member 24 Neighboring gene STARR-seq mESC enhancer starr_42079 Neighboring gene netrin 3 Neighboring gene STARR-positive B cell enhancer ABC_E2472 Neighboring gene cyclin F Neighboring gene microRNA 5134 Neighboring gene microRNA 6965

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. FK506-binding protein-like and FK506-binding protein 8 regulate dual leucine zipper kinase degradation and neuronal responses to axon injury. Lee B, et al. J Biol Chem, 2022 Mar. PMID 35101451, Free PMC Article
  2. A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies. Breslow DK, et al. Nat Genet, 2018 Mar. PMID 29459677, Free PMC Article
  3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of smoothened signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in centriole IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cilium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
tubulin epsilon and delta complex protein 2
Names
uncharacterized protein C16orf59 homolog

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028056.2 → NP_082332.1  tubulin epsilon and delta complex protein 2

    See identical proteins and their annotated locations for NP_082332.1

    Status: VALIDATED

    Source sequence(s)
    AK005395, BC072612
    Consensus CDS
    CCDS28479.1
    UniProtKB/Swiss-Prot
    Q6GQV0, Q9DAZ6
    Related
    ENSMUSP00000024930.8, ENSMUST00000024930.8
    Conserved Domains (1) summary
    pfam15764
    Location:150 → 434
    DUF4693; Domain of unknown function (DUF4693)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    24434028..24439825 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011246632.4 → XP_011244934.1  tubulin epsilon and delta complex protein 2 isoform X1

    Conserved Domains (1) summary
    pfam15764
    Location:150 → 389
    DUF4693; Domain of unknown function (DUF4693)

  2. XM_030250058.2 → XP_030105918.1  tubulin epsilon and delta complex protein 2 isoform X2

    Conserved Domains (1) summary
    pfam15764
    Location:1 → 249
    DUF4693; Domain of unknown function (DUF4693)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6GQV0.1 GenPept UniProtKB/Swiss-Prot:Q6GQV0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous