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Lmntd2 lamin tail domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 72000, updated on 5-Mar-2024

Summary

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Official Symbol
Lmntd2provided by MGI
Official Full Name
lamin tail domain containing 2provided by MGI
Primary source
MGI:MGI:1919250
See related
Ensembl:ENSMUSG00000025500 AllianceGenome:MGI:1919250
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1600016N20Rik
Summary
Predicted to be a structural constituent of chromatin. Acts upstream of or within positive regulation of mRNA splicing, via spliceosome. Predicted to be active in lamin filament. Orthologous to human LMNTD2 (lamin tail domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 95.4), colon adult (RPKM 6.2) and 2 other tissues See more
Orthologs
human all
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Genomic context

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See Lmntd2 in Genome Data Viewer
Location:
7 F5; 7 86.5 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (140789903..140795617, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (141209990..141215517, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 51459 Neighboring gene predicted gene, 22019 Neighboring gene STARR-positive B cell enhancer ABC_E9115 Neighboring gene STARR-positive B cell enhancer ABC_E11375 Neighboring gene Harvey rat sarcoma virus oncogene Neighboring gene leucine rich repeat containing 56 Neighboring gene STARR-positive B cell enhancer ABC_E1749 Neighboring gene STARR-positive B cell enhancer ABC_E2854 Neighboring gene Ras association (RalGDS/AF-6) domain family (N-terminal) member 7 Neighboring gene microRNA 210 Neighboring gene STARR-positive B cell enhancer ABC_E11376 Neighboring gene predicted gene, 51460 Neighboring gene PHD and ring finger domains 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A broadly applicable high-throughput screening strategy identifies new regulators of Dlg4 (Psd-95) alternative splicing. Zheng S, et al. Genome Res, 2013 Jun. PMID 23636947, Free PMC Article
  2. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables structural constituent of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within positive regulation of mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in lamin filament IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
lamin tail domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347565.1 → NP_001334494.1  lamin tail domain-containing protein 2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC108908
    Consensus CDS
    CCDS90350.1
    UniProtKB/TrEMBL
    B7ZMW1
    Related
    ENSMUSP00000130905.2, ENSMUST00000170841.9
    Conserved Domains (1) summary
    pfam00932
    Location:395 → 487
    LTD; Lamin Tail Domain

  2. NM_001382822.1 → NP_001369751.1  lamin tail domain-containing protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC108908
    UniProtKB/Swiss-Prot
    Q0VET5, Q9CW10
    Conserved Domains (1) summary
    pfam00932
    Location:385 → 477
    LTD; Lamin Tail Domain

  3. NM_028050.2 → NP_082326.1  lamin tail domain-containing protein 2 isoform 2

    See identical proteins and their annotated locations for NP_082326.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    BC119093
    Consensus CDS
    CCDS40181.1
    UniProtKB/Swiss-Prot
    Q0VET5, Q9CW10
    Related
    ENSMUSP00000026573.6, ENSMUST00000026573.7
    Conserved Domains (1) summary
    pfam00932
    Location:385 → 477
    LTD; Lamin Tail Domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    140789903..140795617 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153452.1 → XP_036009345.1  lamin tail domain-containing protein 2 isoform X6

    Conserved Domains (1) summary
    pfam00932
    Location:60 → 152
    LTD; Lamin Tail Domain

  2. XM_030243006.1 → XP_030098866.1  lamin tail domain-containing protein 2 isoform X2

    UniProtKB/Swiss-Prot
    Q0VET5, Q9CW10
    Conserved Domains (1) summary
    pfam00932
    Location:385 → 477
    LTD; Lamin Tail Domain

  3. XM_030243007.1 → XP_030098867.1  lamin tail domain-containing protein 2 isoform X3

    Conserved Domains (1) summary
    pfam00932
    Location:279 → 371
    LTD; Lamin Tail Domain

  4. XM_030243004.1 → XP_030098864.1  lamin tail domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    B7ZMW1
    Conserved Domains (1) summary
    pfam00932
    Location:395 → 487
    LTD; Lamin Tail Domain

  5. XM_006536257.5 → XP_006536320.1  lamin tail domain-containing protein 2 isoform X3

    See identical proteins and their annotated locations for XP_006536320.1

    Conserved Domains (1) summary
    pfam00932
    Location:279 → 371
    LTD; Lamin Tail Domain

  6. XM_030243005.2 → XP_030098865.1  lamin tail domain-containing protein 2 isoform X2

    UniProtKB/Swiss-Prot
    Q0VET5, Q9CW10
    Conserved Domains (1) summary
    pfam00932
    Location:385 → 477
    LTD; Lamin Tail Domain

  7. XM_011249859.4 → XP_011248161.1  lamin tail domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011248161.1

    UniProtKB/TrEMBL
    B7ZMW1
    Conserved Domains (1) summary
    pfam00932
    Location:395 → 487
    LTD; Lamin Tail Domain

  8. XM_036153451.1 → XP_036009344.1  lamin tail domain-containing protein 2 isoform X3

    Conserved Domains (1) summary
    pfam00932
    Location:279 → 371
    LTD; Lamin Tail Domain

  9. XM_036153450.1 → XP_036009343.1  lamin tail domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    B7ZMW1
    Conserved Domains (1) summary
    pfam00932
    Location:395 → 487
    LTD; Lamin Tail Domain

  10. XM_017312319.1 → XP_017167808.1  lamin tail domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    B7ZMW1
    Conserved Domains (1) summary
    pfam00932
    Location:395 → 487
    LTD; Lamin Tail Domain

  11. XM_006536258.5 → XP_006536321.1  lamin tail domain-containing protein 2 isoform X4

    Conserved Domains (1) summary
    pfam00932
    Location:395 → 482
    LTD; Lamin Tail Domain

  12. XM_006536259.5 → XP_006536322.1  lamin tail domain-containing protein 2 isoform X5

RNA

  1. XR_880984.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q0VET5.1 GenPept UniProtKB/Swiss-Prot:Q0VET5

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