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Rpusd4 RNA pseudouridylate synthase domain containing 4 [ Mus musculus (house mouse) ]

Gene ID: 71989, updated on 5-Mar-2024

Summary

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Official Symbol
Rpusd4provided by MGI
Official Full Name
RNA pseudouridylate synthase domain containing 4provided by MGI
Primary source
MGI:MGI:1919239
See related
Ensembl:ENSMUSG00000032044 AllianceGenome:MGI:1919239
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2410001E19Rik
Summary
Predicted to enable mitochondrial ribosomal large subunit rRNA binding activity; pseudouridine synthase activity; and tRNA binding activity. Predicted to be involved in enzyme-directed rRNA pseudouridine synthesis; mitochondrial tRNA pseudouridine synthesis; and positive regulation of mitochondrial translation. Predicted to act upstream of or within tRNA processing. Located in mitochondrion. Is expressed in genitourinary system. Orthologous to human RPUSD4 (RNA pseudouridine synthase D4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 8.8), limb E14.5 (RPKM 7.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 A4; 9 20.15 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (35179177..35187253)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (35267881..35275957)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5059 Neighboring gene FAD-dependent oxidoreductase domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_23764 Neighboring gene signal recognition particle receptor alpha Neighboring gene STARR-seq mESC enhancer starr_23765 Neighboring gene family with sequence similarity 118, member B Neighboring gene STARR-positive B cell enhancer ABC_E3823 Neighboring gene RIKEN cDNA 4933422A05 gene Neighboring gene STARR-positive B cell enhancer ABC_E10539 Neighboring gene ribosomal protein L36 pseudogene Neighboring gene predicted gene, 33838

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Beads-free protein immunoprecipitation for a mass spectrometry-based interactome and posttranslational modifications analysis. Mikula M, et al. Proteome Sci, 2015. PMID 26336360, Free PMC Article
  2. ATG5 is required for B cell polarization and presentation of particulate antigens. Arbogast F, et al. Autophagy, 2019 Feb. PMID 30196744, Free PMC Article
  3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  5. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables mitochondrial ribosomal large subunit rRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables pseudouridine synthase activity ISO
Inferred from Sequence Orthology
more info
  
enables tRNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in RNA modification IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA pseudouridine synthesis ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial tRNA pseudouridine synthesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of mitochondrial translation ISO
Inferred from Sequence Orthology
more info
  
involved_in pseudouridine synthesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within rRNA processing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within tRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in ribonucleoprotein granule ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
pseudouridylate synthase RPUSD4, mitochondrial
Names
RNA pseudouridylate synthase domain-containing protein 4
mitochondrial RNA pseudouridine synthase Rpusd4
NP_082316.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028040.2 → NP_082316.1  pseudouridylate synthase RPUSD4, mitochondrial

    See identical proteins and their annotated locations for NP_082316.1

    Status: PROVISIONAL

    Source sequence(s)
    BC061256
    Consensus CDS
    CCDS22962.1
    UniProtKB/Swiss-Prot
    Q9CWX4
    Related
    ENSMUSP00000034543.5, ENSMUST00000034543.5
    Conserved Domains (2) summary
    TIGR00005
    Location:46 → 347
    rluA_subfam; pseudouridine synthase, RluA family
    cd02869
    Location:106 → 329
    PseudoU_synth_RluCD_like; Pseudouridine synthase, RsuA/RluD family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    35179177..35187253
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CWX4.1 GenPept UniProtKB/Swiss-Prot:Q9CWX4

Gene LinkOut

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