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Acad10 acyl-Coenzyme A dehydrogenase family, member 10 [ Mus musculus (house mouse) ]

Gene ID: 71985, updated on 21-Apr-2024

Summary

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Official Symbol
Acad10provided by MGI
Official Full Name
acyl-Coenzyme A dehydrogenase family, member 10provided by MGI
Primary source
MGI:MGI:1919235
See related
Ensembl:ENSMUSG00000029456 AllianceGenome:MGI:1919235
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2410021P16Rik
Summary
Predicted to enable flavin adenine dinucleotide binding activity; hydrolase activity; and oxidoreductase activity, acting on the CH-CH group of donors. Located in mitochondrion. Orthologous to human ACAD10 (acyl-CoA dehydrogenase family member 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in kidney adult (RPKM 23.5), liver adult (RPKM 10.5) and 17 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 F; 5 61.88 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (121759089..121798642, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (121621026..121660603, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_14260 Neighboring gene aldehyde dehydrogenase 2, mitochondrial Neighboring gene STARR-seq mESC enhancer starr_14261 Neighboring gene acyl-Coenzyme A dehydrogenase family, member 12 Neighboring gene BRCA1 associated protein Neighboring gene ataxin 2 Neighboring gene STARR-seq mESC enhancer starr_14264 Neighboring gene microRNA 7031 Neighboring gene SH2B adaptor protein 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Investigating the link of ACAD10 deficiency to type 2 diabetes mellitus. Bloom K, et al. J Inherit Metab Dis, 2018 Jan. PMID 28120165, Free PMC Article
  2. ACAD10 protein expression and Neurobehavioral assessment of Acad10-deficient mice. Bloom K, et al. PLoS One, 2020. PMID 33301490, Free PMC Article
  3. The Cys-N-degron pathway modulates pexophagy through the N-terminal oxidation and arginylation of ACAD10. Shim SM, et al. Autophagy, 2023 Jun. PMID 36184612, Free PMC Article
  4. Short-chain 3-hydroxyacyl-coenzyme A dehydrogenase associates with a protein super-complex integrating multiple metabolic pathways. Narayan SB, et al. PLoS One, 2012. PMID 22496890, Free PMC Article
  5. Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics. Federspiel JD, et al. Mol Cell Proteomics, 2019 Aug 9. PMID 31040226, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acyl-CoA dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-CH group of donors IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
acyl-CoA dehydrogenase family member 10
Names
ACAD-10
NP_082313.2
XP_006530521.1
XP_006530522.1
XP_006530523.1
XP_006530524.1
XP_006530525.1
XP_006530526.1
XP_030110677.1
XP_030110678.1
XP_036021399.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028037.4 → NP_082313.2  acyl-CoA dehydrogenase family member 10

    See identical proteins and their annotated locations for NP_082313.2

    Status: VALIDATED

    Source sequence(s)
    AK050332, CJ136937
    Consensus CDS
    CCDS51643.1
    UniProtKB/Swiss-Prot
    Q8BWQ0, Q8K313, Q8K370
    Related
    ENSMUSP00000107400.2, ENSMUST00000111770.2
    Conserved Domains (2) summary
    PLN02876
    Location:257 → 1056
    PLN02876; acyl-CoA dehydrogenase
    TIGR02247
    Location:41 → 247
    HAD-1A3-hyp; epoxide hydrolase N-terminal domain-like phosphatase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    121759089..121798642 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530459.3 → XP_006530522.1  acyl-CoA dehydrogenase family member 10 isoform X2

    Conserved Domains (2) summary
    PLN02876
    Location:249 → 1048
    PLN02876; acyl-CoA dehydrogenase
    TIGR02247
    Location:41 → 239
    HAD-1A3-hyp; epoxide hydrolase N-terminal domain-like phosphatase

  2. XM_006530458.5 → XP_006530521.1  acyl-CoA dehydrogenase family member 10 isoform X1

    See identical proteins and their annotated locations for XP_006530521.1

    UniProtKB/Swiss-Prot
    Q8BWQ0, Q8K313, Q8K370
    Related
    ENSMUSP00000031412.6, ENSMUST00000031412.12
    Conserved Domains (2) summary
    PLN02876
    Location:257 → 1056
    PLN02876; acyl-CoA dehydrogenase
    TIGR02247
    Location:41 → 247
    HAD-1A3-hyp; epoxide hydrolase N-terminal domain-like phosphatase

  3. XM_030254817.2 → XP_030110677.1  acyl-CoA dehydrogenase family member 10 isoform X3

    Conserved Domains (2) summary
    PLN02876
    Location:161 → 960
    PLN02876; acyl-CoA dehydrogenase
    TIGR02247
    Location:17 → 151
    HAD-1A3-hyp; epoxide hydrolase N-terminal domain-like phosphatase

  4. XM_006530460.5 → XP_006530523.1  acyl-CoA dehydrogenase family member 10 isoform X4

    See identical proteins and their annotated locations for XP_006530523.1

    UniProtKB/Swiss-Prot
    Q8K370
    Conserved Domains (2) summary
    PLN02876
    Location:120 → 919
    PLN02876; acyl-CoA dehydrogenase
    TIGR02247
    Location:1 → 110
    HAD-1A3-hyp; epoxide hydrolase N-terminal domain-like phosphatase

  5. XM_036165506.1 → XP_036021399.1  acyl-CoA dehydrogenase family member 10 isoform X4

    Conserved Domains (2) summary
    PLN02876
    Location:120 → 919
    PLN02876; acyl-CoA dehydrogenase
    TIGR02247
    Location:1 → 110
    HAD-1A3-hyp; epoxide hydrolase N-terminal domain-like phosphatase

  6. XM_030254818.2 → XP_030110678.1  acyl-CoA dehydrogenase family member 10 isoform X5

    UniProtKB/TrEMBL
    Q9CRH8
    Conserved Domains (1) summary
    PLN02876
    Location:16 → 658
    PLN02876; acyl-CoA dehydrogenase

  7. XM_006530463.3 → XP_006530526.1  acyl-CoA dehydrogenase family member 10 isoform X6

    Conserved Domains (2) summary
    TIGR02247
    Location:41 → 58
    HAD-1A3-hyp; epoxide hydrolase N-terminal domain-like phosphatase
    cl09933
    Location:154 → 547
    ACAD; Acyl-CoA dehydrogenase

  8. XM_006530462.1 → XP_006530525.1  acyl-CoA dehydrogenase family member 10 isoform X5

    UniProtKB/TrEMBL
    Q9CRH8
    Conserved Domains (1) summary
    PLN02876
    Location:16 → 658
    PLN02876; acyl-CoA dehydrogenase

  9. XM_006530461.5 → XP_006530524.1  acyl-CoA dehydrogenase family member 10 isoform X4

    See identical proteins and their annotated locations for XP_006530524.1

    UniProtKB/Swiss-Prot
    Q8K370
    Conserved Domains (2) summary
    PLN02876
    Location:120 → 919
    PLN02876; acyl-CoA dehydrogenase
    TIGR02247
    Location:1 → 110
    HAD-1A3-hyp; epoxide hydrolase N-terminal domain-like phosphatase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K370.1 GenPept UniProtKB/Swiss-Prot:Q8K370

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