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Sars2 seryl-aminoacyl-tRNA synthetase 2 [ Mus musculus (house mouse) ]

Gene ID: 71984, updated on 5-Mar-2024

Summary

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Official Symbol
Sars2provided by MGI
Official Full Name
seryl-aminoacyl-tRNA synthetase 2provided by MGI
Primary source
MGI:MGI:1919234
See related
Ensembl:ENSMUSG00000070699 AllianceGenome:MGI:1919234
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SerRS; SerRSmt; D7Ertd353e; 2410015F05Rik
Summary
Predicted to enable ATP binding activity; serine-tRNA ligase activity; and tRNA binding activity. Predicted to be involved in mitochondrial seryl-tRNA aminoacylation. Predicted to act upstream of or within translation. Located in mitochondrion. Is expressed in several structures, including alimentary system; eye; integumental system; nervous system; and respiratory system. Orthologous to human SARS2 (seryl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 17.6), adrenal adult (RPKM 16.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 B1; 7 16.91 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (28441393..28453304)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (28741957..28753879)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene F-box protein 17 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:29526699-29526882 Neighboring gene mitochondrial ribosomal protein S12 Neighboring gene coiled-coil glutamate-rich protein 2 Neighboring gene nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta Neighboring gene STARR-positive B cell enhancer ABC_E128 Neighboring gene sirtuin 2 Neighboring gene predicted gene, 19897 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:29565175-29565376 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:29565964-29566190

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The bidirectional promoter of two genes for the mitochondrial translational apparatus in mouse is regulated by an array of CCAAT boxes interacting with the transcription factor NF-Y. Zanotto E, et al. Nucleic Acids Res, 2007. PMID 17179180, Free PMC Article
  2. Genomic organization, expression, and subcellular localization of mouse mitochondrial seryl-tRNA synthetase. Gibbons WJ Jr, et al. Biochem Biophys Res Commun, 2004 May 7. PMID 15081407
  3. Characterization and tRNA recognition of mammalian mitochondrial seryl-tRNA synthetase. Yokogawa T, et al. J Biol Chem, 2000 Jun 30. PMID 10764807
  4. In vivo and in vitro investigations of heterozygous nebulin knock-out mice disclose a mild skeletal muscle phenotype. Gineste C, et al. Neuromuscul Disord, 2013 Apr. PMID 23375831
  5. ATG5 is required for B cell polarization and presentation of particulate antigens. Arbogast F, et al. Autophagy, 2019 Feb. PMID 30196744, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identification of an array of 4 CCAAT box elements required for efficient transcription of the Sars2 gene.
    Title: The bidirectional promoter of two genes for the mitochondrial translational apparatus in mouse is regulated by an array of CCAAT boxes interacting with the transcription factor NF-Y.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables serine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-tRNA ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables tRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in mitochondrial seryl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in seryl-tRNA aminoacylation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in tRNA aminoacylation for protein translation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
serine--tRNA ligase, mitochondrial
Names
seryl-tRNA synthetase, mitochondrial
seryl-tRNA(Ser/Sec) synthetase
NP_076126.2
XP_006540438.1
XP_006540439.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023637.3 → NP_076126.2  serine--tRNA ligase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_076126.2

    Status: VALIDATED

    Source sequence(s)
    AK010491, BY649585, CX122368
    Consensus CDS
    CCDS21053.1
    UniProtKB/Swiss-Prot
    Q68FL2, Q9CWP1, Q9JJL8
    Related
    ENSMUSP00000092216.5, ENSMUST00000094632.6
    Conserved Domains (3) summary
    PRK05431
    Location:67 → 493
    PRK05431; seryl-tRNA synthetase; Provisional
    cd00770
    Location:185 → 485
    SerRS_core; Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound ...
    cl12057
    Location:67 → 172
    Seryl_tRNA_N; Seryl-tRNA synthetase N-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    28441393..28453304
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540375.5 → XP_006540438.1  serine--tRNA ligase, mitochondrial isoform X1

    Conserved Domains (1) summary
    PRK05431
    Location:67 → 253
    PRK05431; seryl-tRNA synthetase; Provisional

  2. XM_006540376.3 → XP_006540439.1  serine--tRNA ligase, mitochondrial isoform X2

    Conserved Domains (1) summary
    cl00268
    Location:1 → 228
    class_II_aaRS-like_core; Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches ...

RNA

  1. XR_003946566.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JJL8.2 GenPept UniProtKB/Swiss-Prot:Q9JJL8

Gene LinkOut

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