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Mageb16 MAGE family member B16 [ Mus musculus (house mouse) ]

Gene ID: 71967, updated on 5-Mar-2024

Summary

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Official Symbol
Mageb16provided by MGI
Official Full Name
MAGE family member B16provided by MGI
Primary source
MGI:MGI:1919217
See related
Ensembl:ENSMUSG00000046942 AllianceGenome:MGI:1919217
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2410003J06Rik
Summary
Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including brain; egg cylinder; heart; liver; and reproductive system. Orthologous to human MAGEB16 (MAGE family member B16). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in placenta adult (RPKM 10.9) and testis adult (RPKM 3.3) See more
Orthologs
human all
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Genomic context

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Location:
X B; X 38.38 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (78666837..78715041, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (79623231..79671435, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_47437 Neighboring gene cilia and flagella associated protein 47 Neighboring gene STARR-seq mESC enhancer starr_47438 Neighboring gene STARR-seq mESC enhancer starr_47439 Neighboring gene STARR-seq mESC enhancer starr_47441 Neighboring gene STARR-seq mESC enhancer starr_47442 Neighboring gene STARR-seq mESC enhancer starr_47443 Neighboring gene predicted gene, 17817 Neighboring gene STARR-seq mESC enhancer starr_47444 Neighboring gene hepatoma-derived growth factor pseudogene Neighboring gene STARR-seq mESC enhancer starr_47445 Neighboring gene STARR-seq mESC enhancer starr_47446 Neighboring gene STARR-seq mESC enhancer starr_47447 Neighboring gene STARR-seq mESC enhancer starr_47448 Neighboring gene STARR-seq mESC enhancer starr_47449 Neighboring gene ring finger protein pseudogene Neighboring gene prohibitin pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Depletion of Mageb16 induces differentiation of pluripotent stem cells predominantly into mesodermal derivatives. Gaspar JA, et al. Sci Rep, 2017 Oct 27. PMID 29079788, Free PMC Article
  2. Expression dynamics of Mage family genes during self-renewal and differentiation of mouse pluripotent stem and teratocarcinoma cells. Gordeeva O, et al. Oncotarget, 2019 May 14. PMID 31143371, Free PMC Article
  3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
melanoma-associated antigen B16
Names
MAGE-B16 antigen
Novel MAGE family protein
melanoma antigen family B, 16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113734.1 → NP_001107206.1  melanoma-associated antigen B16

    See identical proteins and their annotated locations for NP_001107206.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants encode the same protein.
    Source sequence(s)
    AK010362, BY387905, CJ081836
    Consensus CDS
    CCDS53122.1
    UniProtKB/Swiss-Prot
    Q3TJP9, Q9CWV4
    Related
    ENSMUSP00000109649.4, ENSMUST00000114016.10
    Conserved Domains (1) summary
    pfam01454
    Location:217 → 303
    MAGE; MAGE family

  2. NM_028025.1 → NP_082301.1  melanoma-associated antigen B16

    See identical proteins and their annotated locations for NP_082301.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants encode the same protein.
    Source sequence(s)
    AK010362, BY387905
    Consensus CDS
    CCDS53122.1
    UniProtKB/Swiss-Prot
    Q3TJP9, Q9CWV4
    Related
    ENSMUSP00000087292.4, ENSMUST00000052283.7
    Conserved Domains (1) summary
    pfam01454
    Location:217 → 303
    MAGE; MAGE family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    78666837..78715041 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011247683.3 → XP_011245985.1  melanoma-associated antigen B16 isoform X1

    See identical proteins and their annotated locations for XP_011245985.1

    UniProtKB/Swiss-Prot
    Q3TJP9, Q9CWV4
    Conserved Domains (1) summary
    pfam01454
    Location:217 → 303
    MAGE; MAGE family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CWV4.1 GenPept UniProtKB/Swiss-Prot:Q9CWV4

Gene LinkOut

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