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Castor1 cytosolic arginine sensor for mTORC1 subunit 1 [ Mus musculus (house mouse) ]

Gene ID: 71962, updated on 21-Apr-2024

Summary

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Official Symbol
Castor1provided by MGI
Official Full Name
cytosolic arginine sensor for mTORC1 subunit 1provided by MGI
Primary source
MGI:MGI:1919212
See related
Ensembl:ENSMUSG00000020424 AllianceGenome:MGI:1919212
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gatsl3; 2410008K03Rik
Summary
Predicted to enable arginine binding activity and identical protein binding activity. Predicted to be involved in cellular response to L-arginine and negative regulation of TORC1 signaling. Predicted to be located in cytoplasm. Predicted to be part of GATOR2 complex. Predicted to be active in cytosol. Is expressed in several structures, including Harderian gland; foregut; genitourinary system; skin; and trigeminal nerve. Orthologous to human CASTOR1 (cytosolic arginine sensor for mTORC1 subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in subcutaneous fat pad adult (RPKM 12.0), lung adult (RPKM 10.7) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 A1; 11 2.94 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (4167401..4172409)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (4218166..4222409)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene ring finger protein 215 Neighboring gene microRNA 3060 Neighboring gene coiled-coil domain containing 157 Neighboring gene splicing factor 3a, subunit 1 Neighboring gene STARR-positive B cell enhancer ABC_E727 Neighboring gene TBC1 domain family, member 10a Neighboring gene STARR-positive B cell enhancer ABC_E2978 Neighboring gene predicted gene 11956 Neighboring gene oncostatin M

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mast cell regranulation requires a metabolic switch involving mTORC1 and a glucose-6-phosphate transporter. Iskarpatyoti JA, et al. Cell Rep, 2022 Sep 27. PMID 36170813
  2. Transcriptome analysis of mouse stem cells and early embryos. Sharov AA, et al. PLoS Biol, 2003 Dec. PMID 14691545, Free PMC Article
  3. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mast cell regranulation requires a metabolic switch involving mTORC1 and a glucose-6-phosphate transporter.
    Title: Mast cell regranulation requires a metabolic switch involving mTORC1 and a glucose-6-phosphate transporter.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC141006

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables arginine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables arginine binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein sequestering activity ISO
Inferred from Sequence Orthology
more info
  
enables small molecule sensor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular response to L-arginine IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to L-arginine ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to amino acid starvation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of TORC1 signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of TORC1 signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of TORC1 signaling ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of GATOR2 complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cytosolic arginine sensor for mTORC1 subunit 1
Names
GATS protein-like 3
GATS-like protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028022.2 → NP_082298.1  cytosolic arginine sensor for mTORC1 subunit 1

    See identical proteins and their annotated locations for NP_082298.1

    Status: VALIDATED

    Source sequence(s)
    AK010455, BC039988, CN719833
    Consensus CDS
    CCDS24381.1
    UniProtKB/Swiss-Prot
    Q29R56, Q9CWQ8
    Related
    ENSMUSP00000020699.4, ENSMUST00000020699.4
    Conserved Domains (1) summary
    pfam13840
    Location:260 → 321
    ACT_7; ACT domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    4167401..4172409
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157005.1 → XP_036012898.1  cytosolic arginine sensor for mTORC1 subunit 1 isoform X1

    Conserved Domains (2) summary
    pfam13840
    Location:204 → 268
    ACT_7; ACT domain
    pfam18700
    Location:1 → 16
    Castor1_N; Cytosolic arginine sensor for mTORC1 subunit 1 N-terminal domain

  2. XM_011243752.4 → XP_011242054.1  cytosolic arginine sensor for mTORC1 subunit 1 isoform X1

    Conserved Domains (2) summary
    pfam13840
    Location:204 → 268
    ACT_7; ACT domain
    pfam18700
    Location:1 → 16
    Castor1_N; Cytosolic arginine sensor for mTORC1 subunit 1 N-terminal domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CWQ8.1 GenPept UniProtKB/Swiss-Prot:Q9CWQ8

Gene LinkOut

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