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Myh14 myosin, heavy polypeptide 14 [ Mus musculus (house mouse) ]

Gene ID: 71960, updated on 5-Mar-2024

Summary

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Official Symbol
Myh14provided by MGI
Official Full Name
myosin, heavy polypeptide 14provided by MGI
Primary source
MGI:MGI:1919210
See related
Ensembl:ENSMUSG00000030739 AllianceGenome:MGI:1919210
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
II-C; NHMCII; NMHC II-C; 2400004E04Rik
Summary
Enables ATP binding activity; actin filament binding activity; and microfilament motor activity. Acts upstream of or within actin filament-based movement. Located in several cellular components, including brush border; growth cone; and stress fiber. Part of myosin complex. Is expressed in several structures, including alimentary system; central nervous system; respiratory system; sensory organ; and vibrissa. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 4A and sensorineural hearing loss. Orthologous to human MYH14 (myosin heavy chain 14). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in small intestine adult (RPKM 46.6), colon adult (RPKM 41.7) and 8 other tissues See more
Orthologs
human all
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Genomic context

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See Myh14 in Genome Data Viewer
Location:
7 B3; 7 28.85 cM
Exon count:
46
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (44255227..44320296, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (44605803..44670872, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E290 Neighboring gene napsin A aspartic peptidase Neighboring gene STARR-positive B cell enhancer ABC_E446 Neighboring gene predicted gene 15396 Neighboring gene potassium voltage gated channel, Shaw-related subfamily, member 3 Neighboring gene STARR-seq mESC enhancer starr_18807 Neighboring gene E1A binding protein p300 pseudogene Neighboring gene RIKEN cDNA 2310016G11 gene Neighboring gene STARR-seq mESC enhancer starr_18813 Neighboring gene IZUMO family member 2 Neighboring gene STARR-positive B cell enhancer ABC_E2823 Neighboring gene zinc finger protein 473

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Nonproductive Splicing Prevents Expression of MYH7b Protein in the Mammalian Heart. Lee LA, et al. J Am Heart Assoc, 2021 Jul 20. PMID 34227390, Free PMC Article
  2. Loss of Myh14 Increases Susceptibility to Noise-Induced Hearing Loss in CBA/CaJ Mice. Fu X, et al. Neural Plast, 2016. PMID 28101381, Free PMC Article
  3. NMII forms a contractile transcellular sarcomeric network to regulate apical cell junctions and tissue geometry. Ebrahim S, et al. Curr Biol, 2013 Apr 22. PMID 23562268, Free PMC Article
  4. The effect of including the C2 insert of nonmuscle myosin II-C on neuritogenesis. Saha S, et al. J Biol Chem, 2013 Mar 15. PMID 23355468, Free PMC Article
  5. The positively charged region of the myosin IIC non-helical tailpiece promotes filament assembly. Ronen D, et al. J Biol Chem, 2010 Mar 5. PMID 19959848, Free PMC Article

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Nonproductive Splicing Prevents Expression of MYH7b Protein in the Mammalian Heart.
    Title: Nonproductive Splicing Prevents Expression of MYH7b Protein in the Mammalian Heart.
  2. that Myh14 may play a beneficial role in the protection of the cochlea after acoustic overstimulation in CBA/CaJ mice
    Title: Loss of Myh14 Increases Susceptibility to Noise-Induced Hearing Loss in CBA/CaJ Mice.
  3. we have validated a novel gene, Myh14, as a negative regulator of ISO-induced left ventricular mass hypertrophy in an in vivo mouse model and demonstrated the up-regulation of immediate early gene Myc, fetal gene Nppb, and fibrosis gene Lgals3 in ISO-treated Myh14 deficient hearts compared to controls.
    Title: Genetic Dissection of Cardiac Remodeling in an Isoproterenol-Induced Heart Failure Mouse Model.
  4. NM II-C1C2 may be involved in stabilizing neurites by maintaining their structure at adhesion sites
    Title: The effect of including the C2 insert of nonmuscle myosin II-C on neuritogenesis.
  5. Data indicate that when both NM II-C and II-B are ablated the B-C-/B-C- cardiac myocytes show major defects in karyokinesis.
    Title: Ablation of nonmuscle myosin II-B and II-C reveals a role for nonmuscle myosin II in cardiac myocyte karyokinesis.
  6. This study provides molecular insight into the role of the structurally disordered tailpiece of non-muscle myosin IIC (NMII-C) in shifting the oligomeric equilibrium of NMII-C toward filament assembly and determining its morphology.
    Title: The positively charged region of the myosin IIC non-helical tailpiece promotes filament assembly.
  7. myosin II, directly regulates cellular patterning and alignment within the cochlear sensory epithelium
    Title: Myosin II regulates extension, growth and patterning in the mammalian cochlear duct.
  8. the alternatively spliced isoform of non-muscle myosin II-C is not regulated by myosin light chain phosphorylation
    Title: An alternatively spliced isoform of non-muscle myosin II-C is not regulated by myosin light chain phosphorylation.
  9. mutations and alternative splicing alter the enzymatic and motile activity of nonmuscle myosins II-B and II-C
    Title: Disease-associated mutations and alternative splicing alter the enzymatic and motile activity of nonmuscle myosins II-B and II-C.
  10. a cGMP-independent mechanism for nitric oxide-mediated inhibition of nonmuscle myosin heavy chain II-C induction
    Title: Induction of nonmuscle myosin heavy chain II-C by butyrate in RAW 264.7 mouse macrophages.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (4) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin filament binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to actin filament binding ISO
Inferred from Sequence Orthology
more info
  
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
enables cytoskeletal motor activity IEA
Inferred from Electronic Annotation
more info
  
enables microfilament motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microfilament motor activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to microfilament motor activity ISO
Inferred from Sequence Orthology
more info
  
enables molecular adaptor activity EXP
Inferred from Experiment
more info
 PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within actin filament-based movement IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in actomyosin structure organization ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrion organization ISO
Inferred from Sequence Orthology
more info
  
involved_in neuronal action potential ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of cell shape IEA
Inferred from Electronic Annotation
more info
  
involved_in sensory perception of sound ISO
Inferred from Sequence Orthology
more info
  
involved_in skeletal muscle contraction ISO
Inferred from Sequence Orthology
more info
  
involved_in skeletal muscle tissue development ISO
Inferred from Sequence Orthology
more info
  
involved_in vocalization behavior ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in actomyosin ISO
Inferred from Sequence Orthology
more info
  
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in brush border IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in growth cone IDA
Inferred from Direct Assay
more info
 PubMed 
located_in myelin sheath HDA PubMed 
part_of myosin II complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of myosin II complex ISO
Inferred from Sequence Orthology
more info
  
located_in myosin II filament ISO
Inferred from Sequence Orthology
more info
  
part_of myosin complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in myosin filament IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in stress fiber IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
myosin-14
Names
myosin heavy chain, non-muscle IIc
myosin, heavy chain 14
non-muscle myosin heavy chain IIc
nonmuscle myosin heavy chain
NP_001258467.1
NP_001258469.1
NP_082297.1
XP_011249205.1
XP_017167802.1
XP_030098856.1
XP_036009336.1
XP_036009337.1
XP_036009338.1
XP_036009339.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271538.1 → NP_001258467.1  myosin-14 isoform 1

    See identical proteins and their annotated locations for NP_001258467.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC150895, AC157653
    UniProtKB/TrEMBL
    K3W4R2
    Related
    ENSMUSP00000147115.2, ENSMUST00000207775.2
    Conserved Domains (3) summary
    cd14930
    Location:115 → 825
    MYSc_Myh14_mammals; class II myosin heavy chain 14 motor domain
    pfam00063
    Location:104 → 825
    Myosin_head; Myosin head (motor domain)
    pfam01576
    Location:902 → 1982
    Myosin_tail_1; Myosin tail

  2. NM_001271540.1 → NP_001258469.1  myosin-14 isoform 2

    See identical proteins and their annotated locations for NP_001258469.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AC150895, AC157653
    Consensus CDS
    CCDS71951.1
    UniProtKB/Swiss-Prot
    B3F3T1, Q6URW6, Q80V64, Q80ZE6
    UniProtKB/TrEMBL
    K3W4R2
    Related
    ENSMUSP00000046059.8, ENSMUST00000048102.15
    Conserved Domains (2) summary
    cd14930
    Location:115 → 792
    MYSc_Myh14_mammals; class II myosin heavy chain 14 motor domain
    pfam01576
    Location:869 → 1949
    Myosin_tail_1; Myosin tail

  3. NM_028021.3 → NP_082297.1  myosin-14 isoform 3

    See identical proteins and their annotated locations for NP_082297.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an exon in the coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
    Source sequence(s)
    AC150895, AC157653
    Consensus CDS
    CCDS39943.1
    UniProtKB/TrEMBL
    K3W4R2
    Related
    ENSMUSP00000103531.3, ENSMUST00000107899.10
    Conserved Domains (2) summary
    cd14930
    Location:115 → 784
    MYSc_Myh14_mammals; class II myosin heavy chain 14 motor domain
    pfam01576
    Location:861 → 1941
    Myosin_tail_1; Myosin tail

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    44255227..44320296 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242996.1 → XP_030098856.1  myosin-14 isoform X2

    UniProtKB/TrEMBL
    K3W4R2
    Conserved Domains (2) summary
    cd14930
    Location:115 → 784
    MYSc_Myh14_mammals; class II myosin heavy chain 14 motor domain
    pfam01576
    Location:861 → 1941
    Myosin_tail_1; Myosin tail

  2. XM_036153445.1 → XP_036009338.1  myosin-14 isoform X2

    UniProtKB/TrEMBL
    K3W4R2
    Conserved Domains (2) summary
    cd14930
    Location:115 → 784
    MYSc_Myh14_mammals; class II myosin heavy chain 14 motor domain
    pfam01576
    Location:861 → 1941
    Myosin_tail_1; Myosin tail

  3. XM_036153444.1 → XP_036009337.1  myosin-14 isoform X2

    UniProtKB/TrEMBL
    K3W4R2
    Conserved Domains (2) summary
    cd14930
    Location:115 → 784
    MYSc_Myh14_mammals; class II myosin heavy chain 14 motor domain
    pfam01576
    Location:861 → 1941
    Myosin_tail_1; Myosin tail

  4. XM_036153443.1 → XP_036009336.1  myosin-14 isoform X2

    UniProtKB/TrEMBL
    K3W4R2
    Conserved Domains (2) summary
    cd14930
    Location:115 → 784
    MYSc_Myh14_mammals; class II myosin heavy chain 14 motor domain
    pfam01576
    Location:861 → 1941
    Myosin_tail_1; Myosin tail

  5. XM_036153446.1 → XP_036009339.1  myosin-14 isoform X2

    UniProtKB/TrEMBL
    K3W4R2
    Conserved Domains (2) summary
    cd14930
    Location:115 → 784
    MYSc_Myh14_mammals; class II myosin heavy chain 14 motor domain
    pfam01576
    Location:861 → 1941
    Myosin_tail_1; Myosin tail

  6. XM_011250903.2 → XP_011249205.1  myosin-14 isoform X1

    See identical proteins and their annotated locations for XP_011249205.1

    UniProtKB/Swiss-Prot
    B3F3T1, Q6URW6, Q80V64, Q80ZE6
    UniProtKB/TrEMBL
    K3W4R2
    Conserved Domains (2) summary
    cd14930
    Location:115 → 792
    MYSc_Myh14_mammals; class II myosin heavy chain 14 motor domain
    pfam01576
    Location:869 → 1949
    Myosin_tail_1; Myosin tail

  7. XM_017312313.2 → XP_017167802.1  myosin-14 isoform X1

    UniProtKB/Swiss-Prot
    B3F3T1, Q6URW6, Q80V64, Q80ZE6
    UniProtKB/TrEMBL
    K3W4R2
    Conserved Domains (2) summary
    cd14930
    Location:115 → 792
    MYSc_Myh14_mammals; class II myosin heavy chain 14 motor domain
    pfam01576
    Location:869 → 1949
    Myosin_tail_1; Myosin tail
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6URW6.1 GenPept UniProtKB/Swiss-Prot:Q6URW6

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