Riox1 ribosomal oxygenase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Riox1provided by MGI
Official Full Name: ribosomal oxygenase 1provided by MGI
Primary source: MGI:MGI:1919202
See related: Ensembl:ENSMUSG00000046791 AllianceGenome:MGI:1919202
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NO66; MAPJD; 2410016O06Rik
Summary: Enables histone H3-methyl-lysine-36 demethylase activity; histone H3-methyl-lysine-4 demethylase activity; and iron ion binding activity. Involved in histone lysine demethylation; negative regulation of osteoblast differentiation; and negative regulation of transcription, DNA-templated. Located in nucleolus. Is expressed in skeleton and tibia cartilage condensation. Orthologous to human RIOX1 (ribosomal oxygenase 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human all
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Genomic context

Location:: 12 D1; 12 38.97 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (83997382..83999727)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (83950608..83952953)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mechanisms Regulating Muscle Protein Synthesis in CKD.
Title: Mechanisms Regulating Muscle Protein Synthesis in CKD.
NO66 regulates bone formation, at least in part, via regulating the number of bone-forming cells and expression of multiple genes that are critical for these processes
Title: Mesenchymal Deletion of Histone Demethylase NO66 in Mice Promotes Bone Formation.
Data indicate that mesenchymal overexpression of nucleolar protein 66 (NO66) inhibits skeletal cell proliferation.
Title: Mesenchyme-specific overexpression of nucleolar protein 66 in mice inhibits skeletal growth and bone formation.
propose that Osx is a molecular switch for the formation of an active chromatin state during osteoblast differentiation, whereas NO66 helps gene repression through histone demethylation and/or formation of a repressor complex
Title: Osterix and NO66 histone demethylase control the chromatin of Osterix target genes during osteoblast differentiation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 2-oxoglutarate-dependent dioxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables 2-oxoglutarate-dependent dioxygenase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables 2-oxoglutarate-dependent dioxygenase activity	ISO Inferred from Sequence Orthology more info
enables RNA binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables dioxygenase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K36 demethylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone H3K36 demethylase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone H3K36me/H3K36me2 demethylase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K4 demethylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone H3K4me/H3K4me2/H3K4me3 demethylase activity	IDA Inferred from Direct Assay more info	PubMed
enables iron ion binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables peptidyl-histidine dioxygenase activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein demethylase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein demethylase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chromatin organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chromatin remodeling	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of osteoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein demethylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within ribosome biogenesis	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of nucleolar preribosome	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ribosomal oxygenase 1

Names: bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66; histone lysine demethylase NO66; lysine-specific demethylase NO66; myc associated protein with JmjC domain; nucleolar protein 66

NP_076122.2

EC 1.14.11.27

EC 1.14.11.79

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.