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Endod1 endonuclease domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 71946, updated on 5-Mar-2024

Summary

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Official Symbol
Endod1provided by MGI
Official Full Name
endonuclease domain containing 1provided by MGI
Primary source
MGI:MGI:1919196
See related
Ensembl:ENSMUSG00000037419 AllianceGenome:MGI:1919196
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2210414F18Rik; 2310067E08Rik
Summary
Predicted to enable endonuclease activity; metal ion binding activity; and nucleic acid binding activity. Predicted to be located in extracellular region. Is expressed in liver; metanephros; nervous system; neural retina; and olfactory epithelium. Orthologous to human ENDOD1 (endonuclease domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in colon adult (RPKM 61.0), cerebellum adult (RPKM 29.5) and 24 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 A1; 9 3.96 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (14265286..14292538, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (14353990..14381242, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_23346 Neighboring gene predicted gene, 34069 Neighboring gene STARR-positive B cell enhancer ABC_E247 Neighboring gene sestrin 3 Neighboring gene predicted gene, 34156 Neighboring gene STARR-seq mESC enhancer starr_23348 Neighboring gene lysine (K)-specific demethylase 4D-like Neighboring gene lysine (K)-specific demethylase 4D Neighboring gene STARR-positive B cell enhancer ABC_E248

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Synthetic lethality between TP53 and ENDOD1. Tang Z, et al. Nat Commun, 2022 May 23. PMID 35606358, Free PMC Article
  2. Rescue of neuropsychiatric phenotypes in a mouse model of 16p11.2 duplication syndrome by genetic correction of an epilepsy network hub. Forrest MP, et al. Nat Commun, 2023 Feb 17. PMID 36808153, Free PMC Article
  3. Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Miller JA, et al. Development, 2013 Nov. PMID 24154525, Free PMC Article
  4. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
  5. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Synthetic lethality between TP53 and ENDOD1.
    Title: Synthetic lethality between TP53 and ENDOD1.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
endonuclease domain-containing 1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028013.3 → NP_082289.2  endonuclease domain-containing 1 protein precursor

    See identical proteins and their annotated locations for NP_082289.2

    Status: VALIDATED

    Source sequence(s)
    AK173036, BY483505
    Consensus CDS
    CCDS22821.1
    UniProtKB/Swiss-Prot
    Q4VA96, Q8C522, Q8C5M1, Q8VE35
    UniProtKB/TrEMBL
    Q69ZY2
    Related
    ENSMUSP00000127751.2, ENSMUST00000167549.2
    Conserved Domains (1) summary
    cd00091
    Location:65 → 281
    NUC; DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers.

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    14265286..14292538 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017313601.2 → XP_017169090.1  endonuclease domain-containing 1 protein isoform X1

    UniProtKB/TrEMBL
    Q3UQH3
    Conserved Domains (2) summary
    pfam15070
    Location:123 → 172
    GOLGA2L5; Putative golgin subfamily A member 2-like protein 5
    cl00089
    Location:1 → 127
    NUC; DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C522.2 GenPept UniProtKB/Swiss-Prot:Q8C522

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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