Car13 carbonic anhydrase 13 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Car13provided by MGI
Official Full Name: carbonic anhydrase 13provided by MGI
Primary source: MGI:MGI:1931322
See related: Ensembl:ENSMUSG00000027555 AllianceGenome:MGI:1931322
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ca13; 2310075C21Rik
Summary: Enables carbonate dehydratase activity. Predicted to be involved in one-carbon metabolic process. Located in cytosol; intracellular membrane-bounded organelle; and myelin sheath. Is expressed in several structures, including alimentary system; ear; genitourinary system; meninges; and musculature. Orthologous to human CA13 (carbonic anhydrase 13). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in large intestine adult (RPKM 12.9), bladder adult (RPKM 5.8) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 A1; 3 3.12 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (14706787..14728062)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (14641727..14663002)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

During inner ear development, transcripts of four cytosolic isozymes (Car1, Car2, Car3, and Car13), two membrane-bound isozymes (Car12 and Car14), and two CA-related proteins (Car8 and Car11) were expressed at higher levels than other isozymes.
Title: A systematic survey of carbonic anhydrase mRNA expression during mammalian inner ear development.
Car5b and Car13 showed the highest signals in the mouse harderian gland.
Title: Carbonic anhydrases in the mouse harderian gland.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)
Endonuclease-mediated (1)

General gene information

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Markers

Car13 (e-PCR), detects polymorphism
- UniSTS:506768

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carbonate dehydratase activity	IBA Inferred from Biological aspect of Ancestor more info
enables carbonate dehydratase activity	IDA Inferred from Direct Assay more info	PubMed
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in one-carbon metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info	PubMed
located_in myelin sheath	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: carbonic anhydrase 13

Names: CA-XIII; carbonate dehydratase XIII; carbonic anhydrase XIII

NP_078771.1

EC 4.2.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_024495.5 → NP_078771.1 carbonic anhydrase 13

See identical proteins and their annotated locations for NP_078771.1

Status: VALIDATED

Source sequence(s)

AK151978, AK162621

Consensus CDS

CCDS17247.1

UniProtKB/Swiss-Prot

Q3UBM2, Q9D6N1

Related

ENSMUSP00000029071.9, ENSMUST00000029071.9

Conserved Domains (1) summary

cd03119
Location:2 → 261

alpha_CA_I_II_III_XIII; Carbonic anhydrase alpha, isozymes I, II, and III and XIII. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on ...