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Tube1 tubulin, epsilon 1 [ Mus musculus (house mouse) ]

Gene ID: 71924, updated on 11-Apr-2024

Summary

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Official Symbol
Tube1provided by MGI
Official Full Name
tubulin, epsilon 1provided by MGI
Primary source
MGI:MGI:1919174
See related
Ensembl:ENSMUSG00000019845 AllianceGenome:MGI:1919174
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tube; 2310061K05Rik
Summary
Predicted to enable GTP binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in microtubule cytoskeleton organization and mitotic cell cycle. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm and microtubule. Is expressed in several structures, including central nervous system; eye; and palatal shelf. Orthologous to human TUBE1 (tubulin epsilon 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in thymus adult (RPKM 18.3), CNS E11.5 (RPKM 7.0) and 10 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 B1; 10 20.16 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (39009946..39035863)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (39133949..39151058)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene laminin, alpha 4 Neighboring gene STARR-seq mESC enhancer starr_26379 Neighboring gene STARR-seq mESC enhancer starr_26383 Neighboring gene family with sequence similarity 229, member B Neighboring gene STARR-seq mESC enhancer starr_26384 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:38891010-38891195 Neighboring gene STARR-positive B cell enhancer ABC_E3883 Neighboring gene STARR-positive B cell enhancer ABC_E1797 Neighboring gene cellular communication network factor 6 Neighboring gene STARR-seq mESC enhancer starr_26386 Neighboring gene STARR-seq mESC enhancer starr_26387 Neighboring gene nucleophosmin 1 pseudogene Neighboring gene predicted gene, 31562

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Pitx3 directly regulates Foxe3 during early lens development. Ahmad N, et al. Int J Dev Biol, 2013. PMID 24307298
  2. Keratin 13 deficiency causes white sponge nevus in mice. Simonson L, et al. Dev Biol, 2020 Dec 1. PMID 32758484, Free PMC Article
  3. TRAF4 promotes TGF-β receptor signaling and drives breast cancer metastasis. Zhang L, et al. Mol Cell, 2013 Sep 12. PMID 23973329
  4. A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies. Breslow DK, et al. Nat Genet, 2018 Mar. PMID 29459677, Free PMC Article
  5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural constituent of cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule-based process IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tubulin epsilon chain
Names
epsilon-tubulin 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028006.2 → NP_082282.1  tubulin epsilon chain

    See identical proteins and their annotated locations for NP_082282.1

    Status: PROVISIONAL

    Source sequence(s)
    AK148039
    Consensus CDS
    CCDS23787.1
    UniProtKB/Swiss-Prot
    Q9D6T1
    Related
    ENSMUSP00000019991.8, ENSMUST00000019991.8
    Conserved Domains (1) summary
    cd02190
    Location:2 → 457
    epsilon_tubulin; The epsilon-tubulin family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    39009946..39035863
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156032.1 → XP_036011925.1  tubulin epsilon chain isoform X3

    Conserved Domains (1) summary
    cl10017
    Location:2 → 318
    Tubulin_FtsZ_Cetz-like; Tubulin protein family of FtsZ and CetZ-like

  2. XM_036156030.1 → XP_036011923.1  tubulin epsilon chain isoform X1

    UniProtKB/Swiss-Prot
    Q9D6T1
    Conserved Domains (1) summary
    cd02190
    Location:2 → 457
    epsilon_tubulin; The epsilon-tubulin family

  3. XM_036156029.1 → XP_036011922.1  tubulin epsilon chain isoform X1

    UniProtKB/Swiss-Prot
    Q9D6T1
    Conserved Domains (1) summary
    cd02190
    Location:2 → 457
    epsilon_tubulin; The epsilon-tubulin family

  4. XM_036156031.1 → XP_036011924.1  tubulin epsilon chain isoform X1

    UniProtKB/Swiss-Prot
    Q9D6T1
    Conserved Domains (1) summary
    cd02190
    Location:2 → 457
    epsilon_tubulin; The epsilon-tubulin family

  5. XM_006512861.5 → XP_006512924.1  tubulin epsilon chain isoform X2

    See identical proteins and their annotated locations for XP_006512924.1

    Conserved Domains (1) summary
    cd02190
    Location:1 → 382
    epsilon_tubulin; The epsilon-tubulin family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D6T1.1 GenPept UniProtKB/Swiss-Prot:Q9D6T1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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