Antxr2 anthrax toxin receptor 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Antxr2provided by MGI
Official Full Name: anthrax toxin receptor 2provided by MGI
Primary source: MGI:MGI:1919164
See related: Ensembl:ENSMUSG00000029338 AllianceGenome:MGI:1919164
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CMG2; CMG-2; cI-35; 2310046B19Rik
Summary: Predicted to enable transmembrane signaling receptor activity. Acts upstream of or within reproductive process and toxin transport. Located in external side of plasma membrane. Is integral component of membrane. Is expressed in retina. Human ortholog(s) of this gene implicated in fibroma and hyaline fibromatosis syndrome. Orthologous to human ANTXR2 (ANTXR cell adhesion molecule 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in heart adult (RPKM 13.0), subcutaneous fat pad adult (RPKM 7.8) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 E3; 5 47.77 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (98032547..98178876, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (97884688..98031017, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Capillary morphogenesis gene 2 (CMG2) mediates growth factor-induced angiogenesis by regulating endothelial cell chemotaxis.
Title: Capillary morphogenesis gene 2 (CMG2) mediates growth factor-induced angiogenesis by regulating endothelial cell chemotaxis.
Loss of Antxr2 promotes accumulation of collagen VI. Antxr2 is also associated with collagen VI signaling and degradation.
Title: CMG2/ANTXR2 regulates extracellular collagen VI which accumulates in hyaline fibromatosis syndrome.
Anthrax Toxin Protective Antigen Variants That Selectively Utilize either the CMG2 or TEM8 Receptors for Cellular Uptake and Tumor Targeting.
Title: Anthrax Toxin Protective Antigen Variants That Selectively Utilize either the CMG2 or TEM8 Receptors for Cellular Uptake and Tumor Targeting.
blood pressure measured under anesthesia in Antxr2 siRNA-injected mice rose significantly compared with that of the controls, suggesting that ANTXR2 is a causative gene in the human 4q21 GWAS-blood pressure locus.
Title: ANTXR2 is a potential causative gene in the genome-wide association study of the blood pressure locus 4q21.
Silencing CMG2 using targeted siRNAs provided almost complete protection against anthrax lethal toxin-induced cytotoxicity and death in murine and human macrophages.
Title: Targeted silencing of anthrax toxin receptors protects against anthrax toxins.
we have discovered that ANTXR1 and ANTXR2 function as positive regulators of MT1-MMP activity.
Title: Anthrax toxin receptor 2 functions in ECM homeostasis of the murine reproductive tract and promotes MMP activity.
these results demonstrate that CMG2 is not required for normal mouse embryonic development but is indispensable for murine parturition
Title: Capillary morphogenesis protein-2 is required for mouse parturition by maintaining uterine collagen homeostasis.
Data show that the two different PA oligomers are equally stabilized by ANTXR interactions.
Title: Anthrax toxin receptor drives protective antigen oligomerization and stabilizes the heptameric and octameric oligomer by a similar mechanism.
This work demonstrates that anthrax toxin uptake through CMG2 and the resulting impairment of myeloid cells are essential to anthrax infection.
Title: Anthrax toxin targeting of myeloid cells through the CMG2 receptor is essential for establishment of Bacillus anthracis infections in mice.
ANTXR2/CMG2 functions to promote endothelial proliferation and morphogenesis during sprouting angiogenesis, consistent with the endothelial expression of ANTXR2/CMG2 in several vascular beds.
Title: Anthrax toxin receptor 2 is expressed in murine and tumor vasculature and functions in endothelial proliferation and morphogenesis.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables signaling receptor activity	IEA Inferred from Electronic Annotation more info
enables transmembrane signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within collagen fibril organization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within collagen fibril organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within reproductive process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within single fertilization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within single fertilization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within uterus development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within uterus development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: anthrax toxin receptor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133738.3 → NP_598499.1 anthrax toxin receptor 2 precursor

See identical proteins and their annotated locations for NP_598499.1

Status: VALIDATED

Source sequence(s)

AC125131, AC133519

Consensus CDS

CCDS39177.1

UniProtKB/Swiss-Prot

Q6DFX2, Q99L17

UniProtKB/TrEMBL

A0A0G2JE26, Q3TCL6

Related

ENSMUSP00000031281.10, ENSMUST00000031281.14

Conserved Domains (3) summary

cd01474
Location:39 → 221

vWA_ATR; ATR (Anthrax Toxin Receptor): Anthrax toxin is a key virulence factor for Bacillus anthracis, the causative agent of anthrax. ATR is the cellular receptor for the anthrax protective antigen and facilitates entry of the toxin into cells. The VWA domain in ...

pfam05586
Location:394 → 485

Ant_C; Anthrax receptor C-terminus region

pfam05587
Location:223 → 317

Anth_Ig; Anthrax receptor extracellular domain