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Jsrp1 junctional sarcoplasmic reticulum protein 1 [ Mus musculus (house mouse) ]

Gene ID: 71912, updated on 21-Apr-2024

Summary

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Official Symbol
Jsrp1provided by MGI
Official Full Name
junctional sarcoplasmic reticulum protein 1provided by MGI
Primary source
MGI:MGI:1916700
See related
Ensembl:ENSMUSG00000020216 AllianceGenome:MGI:1916700
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
JP45; JP-45; 2300003C06Rik; 2310032K21Rik
Summary
Acts upstream of or within protein localization to membrane and regulation of ryanodine-sensitive calcium-release channel activity. Located in sarcoplasmic reticulum. Is expressed in skeletal muscle and tongue. Orthologous to human JSRP1 (junctional sarcoplasmic reticulum protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in mammary gland adult (RPKM 5.5), ovary adult (RPKM 5.4) and 11 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 C1; 10 39.72 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (80644330..80649359, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (80808494..80813741, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene splicing factor 3a, subunit 2 Neighboring gene Amh promoter region Neighboring gene anti-Mullerian hormone Neighboring gene STARR-seq mESC enhancer starr_27299 Neighboring gene STARR-positive B cell enhancer ABC_E369 Neighboring gene ornithine decarboxylase antizyme 1 Neighboring gene microRNA 1982 Neighboring gene leucine rich repeat and Ig domain containing 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Endogenously determined restriction of food intake overcomes excitation-contraction uncoupling in JP45KO mice with aging. Delbono O, et al. Exp Gerontol, 2012 Apr. PMID 22297108, Free PMC Article
  2. Loss of skeletal muscle strength by ablation of the sarcoplasmic reticulum protein JP45. Delbono O, et al. Proc Natl Acad Sci U S A, 2007 Dec 11. PMID 18077436, Free PMC Article
  3. The junctional SR protein JP-45 affects the functional expression of the voltage-dependent Ca2+ channel Cav1.1. Anderson AA, et al. J Cell Sci, 2006 May 15. PMID 16638807, Free PMC Article
  4. Role of the JP45-Calsequestrin Complex on Calcium Entry in Slow Twitch Skeletal Muscles. Mosca B, et al. J Biol Chem, 2016 Jul 8. PMID 27189940, Free PMC Article
  5. Enhanced dihydropyridine receptor calcium channel activity restores muscle strength in JP45/CASQ1 double knockout mice. Mosca B, et al. Nat Commun, 2013. PMID 23443569, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Calcium entry activated by ablation of both JP45-CASQ1 and JP45-CASQ2 complexes supports tetanic force development in slow twitch soleus muscles.
    Title: Role of the JP45-Calsequestrin Complex on Calcium Entry in Slow Twitch Skeletal Muscles.
  2. Ca(2+) transients evoked by tetanic stimulation are the result of massive Ca(2+) influx due to enhanced Ca(v)1.1 channel activity, which restores muscle strength in JP45/CASQ1 double knockout mice.
    Title: Enhanced dihydropyridine receptor calcium channel activity restores muscle strength in JP45/CASQ1 double knockout mice.
  3. One of the molecules involved in the development or maintenance of skeletal muscle strength.
    Title: Loss of skeletal muscle strength by ablation of the sarcoplasmic reticulum protein JP45.
  4. cloning, developmental expression, localization in sarcoplasmic reticulum, interaction with alpha 1.1 voltage-gated calcium channel, and involvement in skeletal muscle excitation-contraction coupling
    Title: The novel skeletal muscle sarcoplasmic reticulum JP-45 protein. Molecular cloning, tissue distribution, developmental expression, and interaction with alpha 1.1 subunit of the voltage-gated calcium channel.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within protein localization to membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of ryanodine-sensitive calcium-release channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of ryanodine-sensitive calcium-release channel activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in skeletal muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in skeletal muscle contraction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within striated muscle contraction ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in sarcoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in sarcoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
junctional sarcoplasmic reticulum protein 1
Names
junctional-face membrane protein of 45 kDa homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028001.3 → NP_082277.2  junctional sarcoplasmic reticulum protein 1

    See identical proteins and their annotated locations for NP_082277.2

    Status: VALIDATED

    Source sequence(s)
    AC166937
    Consensus CDS
    CCDS24034.2
    UniProtKB/Swiss-Prot
    Q3MI48, Q9D755
    UniProtKB/TrEMBL
    M0QW57
    Related
    ENSMUSP00000137666.2, ENSMUST00000181039.8
    Conserved Domains (2) summary
    PRK14954
    Location:160 → 276
    PRK14954; DNA polymerase III subunits gamma and tau; Provisional
    pfam15312
    Location:119 → 178
    JSRP; Junctional sarcoplasmic reticulum protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    80644330..80649359 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156028.1 → XP_036011921.1  junctional sarcoplasmic reticulum protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q3MI48, Q9D755
    UniProtKB/TrEMBL
    M0QW57
    Conserved Domains (2) summary
    PRK14954
    Location:160 → 276
    PRK14954; DNA polymerase III subunits gamma and tau; Provisional
    pfam15312
    Location:119 → 178
    JSRP; Junctional sarcoplasmic reticulum protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3MI48.2 GenPept UniProtKB/Swiss-Prot:Q3MI48

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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