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Paqr7 progestin and adipoQ receptor family member VII [ Mus musculus (house mouse) ]

Gene ID: 71904, updated on 11-Apr-2024

Summary

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Official Symbol
Paqr7provided by MGI
Official Full Name
progestin and adipoQ receptor family member VIIprovided by MGI
Primary source
MGI:MGI:1919154
See related
Ensembl:ENSMUSG00000037348 AllianceGenome:MGI:1919154
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mPR; Mpra; PGLP; mPR alpha; 2310021M12Rik
Summary
Predicted to enable steroid binding activity and steroid hormone receptor activity. Predicted to be involved in response to steroid hormone. Predicted to act upstream of or within oogenesis. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and integumental system. Orthologous to human PAQR7 (progestin and adipoQ receptor family member 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 26.7), lung adult (RPKM 26.0) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 D2.3; 4 66.8 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (134224315..134237548)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (134496761..134510237)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_11679 Neighboring gene stathmin 1 Neighboring gene STARR-positive B cell enhancer ABC_E9602 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:134051274-134051427 Neighboring gene ribosomal protein 10 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E4680 Neighboring gene aurora kinase A and ninein interacting protein Neighboring gene mitochondrial fission regulator 1-like Neighboring gene STARR-positive B cell enhancer mm9_chr4:134091101-134091402

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Progesterone-facilitated lordosis of estradiol-primed mice is attenuated by knocking down expression of membrane progestin receptors in the midbrain. Frye CA, et al. Steroids, 2014 Mar. PMID 24269738, Free PMC Article
  2. Membrane progestin receptors alpha and gamma in renal epithelium. Lemale J, et al. Biochim Biophys Acta, 2008 Dec. PMID 18722485
  3. Identification of promethin and PGLP as two novel up-regulated genes in PPARgamma1-induced adipogenic mouse liver. Yu S, et al. Biochimie, 2004 Nov. PMID 15589683
  4. Activation of enteroendocrine membrane progesterone receptors promotes incretin secretion and improves glucose tolerance in mice. Flock GB, et al. Diabetes, 2013 Jan. PMID 22933106, Free PMC Article
  5. Pancreatic expression and mitochondrial localization of the progestin-adipoQ receptor PAQR10. Góñez LJ, et al. Mol Med, 2008 Nov-Dec. PMID 18769639, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Progestin and adipoQ receptor 7 (PAQR7) mediate the anti-apoptotic effect of P4 on human granulosa cells and its deficiency reduces ovarian function in female mice.
    Title: Progestin and adipoQ receptor 7 (PAQR7) mediate the anti-apoptotic effect of P4 on human granulosa cells and its deficiency reduces ovarian function in female mice.
  2. Paqr7 and Paqr8 are expressed in the midbrain ventral tegmental area of proestrous mice.
    Title: Progesterone-facilitated lordosis of estradiol-primed mice is attenuated by knocking down expression of membrane progestin receptors in the midbrain.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclear steroid receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables steroid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within oogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in response to steroid hormone IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
membrane progestin receptor alpha
Names
PPAR-gamma-induced liver protein
membrane progesterone P4 receptor alpha
membrane progesterone receptor alpha
progesterone and adipoQ receptor family member 7
progestin and adipoQ receptor family member 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001285845.2 → NP_001272774.1  membrane progestin receptor alpha

    See identical proteins and their annotated locations for NP_001272774.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All variants (1 through 5) encode the same protein.
    Source sequence(s)
    AL669982
    Consensus CDS
    CCDS18773.1
    UniProtKB/Swiss-Prot
    Q3TDA0, Q80ZE4, Q8BNZ7, Q9D790
    UniProtKB/TrEMBL
    Q3TT73
    Conserved Domains (1) summary
    pfam03006
    Location:65 → 289
    HlyIII; Haemolysin-III related

  2. NM_001285846.2 → NP_001272775.1  membrane progestin receptor alpha

    See identical proteins and their annotated locations for NP_001272775.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All variants (1 through 5) encode the same protein.
    Source sequence(s)
    AL669982
    Consensus CDS
    CCDS18773.1
    UniProtKB/Swiss-Prot
    Q3TDA0, Q80ZE4, Q8BNZ7, Q9D790
    UniProtKB/TrEMBL
    Q3TT73
    Conserved Domains (1) summary
    pfam03006
    Location:65 → 289
    HlyIII; Haemolysin-III related

  3. NM_001285847.2 → NP_001272776.1  membrane progestin receptor alpha

    See identical proteins and their annotated locations for NP_001272776.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All variants (1 through 5) encode the same protein.
    Source sequence(s)
    AL669982
    Consensus CDS
    CCDS18773.1
    UniProtKB/Swiss-Prot
    Q3TDA0, Q80ZE4, Q8BNZ7, Q9D790
    UniProtKB/TrEMBL
    Q3TT73
    Related
    ENSMUSP00000125932.2, ENSMUST00000095074.4
    Conserved Domains (1) summary
    pfam03006
    Location:65 → 289
    HlyIII; Haemolysin-III related

  4. NM_001285849.2 → NP_001272778.1  membrane progestin receptor alpha

    See identical proteins and their annotated locations for NP_001272778.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. All variants (1 through 5) encode the same protein.
    Source sequence(s)
    AL669982
    Consensus CDS
    CCDS18773.1
    UniProtKB/Swiss-Prot
    Q3TDA0, Q80ZE4, Q8BNZ7, Q9D790
    UniProtKB/TrEMBL
    Q3TT73
    Conserved Domains (1) summary
    pfam03006
    Location:65 → 289
    HlyIII; Haemolysin-III related

  5. NM_027995.4 → NP_082271.1  membrane progestin receptor alpha

    See identical proteins and their annotated locations for NP_082271.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All variants (1 through 5) encode the same protein.
    Source sequence(s)
    AL669982
    Consensus CDS
    CCDS18773.1
    UniProtKB/Swiss-Prot
    Q3TDA0, Q80ZE4, Q8BNZ7, Q9D790
    UniProtKB/TrEMBL
    Q3TT73
    Related
    ENSMUSP00000080240.4, ENSMUST00000081525.4
    Conserved Domains (1) summary
    pfam03006
    Location:65 → 289
    HlyIII; Haemolysin-III related

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    134224315..134237548
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164451.1 → XP_036020344.1  membrane progestin receptor alpha isoform X1

    UniProtKB/Swiss-Prot
    Q3TDA0, Q80ZE4, Q8BNZ7, Q9D790
    UniProtKB/TrEMBL
    Q3TT73
    Conserved Domains (1) summary
    pfam03006
    Location:65 → 289
    HlyIII; Haemolysin-III related
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80ZE4.2 GenPept UniProtKB/Swiss-Prot:Q80ZE4

Gene LinkOut

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